Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling to Predict the Impact of CYP2C9 Genetic Polymorphisms, Co-Medication and Formulation on the Pharmacokinetics and Pharmacodynamics of Flurbiprofen

Physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) models can serve as a powerful framework for predicting the influence as well as the interaction of formulation, genetic polymorphism and co-medication on the pharmacokinetics and pharmacodynamics of drug substances. In this study, flur...

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Detalles Bibliográficos
Autores principales: Loisios-Konstantinidis, Ioannis, Cristofoletti, Rodrigo, Jamei, Masoud, Turner, David, Dressman, Jennifer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7693160/
https://www.ncbi.nlm.nih.gov/pubmed/33147873
http://dx.doi.org/10.3390/pharmaceutics12111049

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