Serology- and PCR-based cumulative incidence of SARS-CoV-2 infection in adults in a successfully contained early hotspot (CoMoLo study), Germany, May to June 2020

Three months after a coronavirus disease (COVID-19) outbreak in Kupferzell, Germany, a population-based study (n = 2,203) found no RT-PCR-positives. IgG-ELISA seropositivity with positive virus neutralisation tests was 7.7% (95% confidence interval (CI): 6.5–9.1) and 4.3% with negative neutralisatio...

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Detalles Bibliográficos
Autores principales: Santos-Hövener, Claudia, Neuhauser, Hannelore K, Rosario, Angelika Schaffrath, Busch, Markus, Schlaud, Martin, Hoffmann, Robert, Gößwald, Antje, Koschollek, Carmen, Hoebel, Jens, Allen, Jennifer, Haack-Erdmann, Antje, Brockmann, Stefan, Ziese, Thomas, Nitsche, Andreas, Michel, Janine, Haller, Sebastian, Wilking, Hendrik, Hamouda, Osamah, Corman, Victor M, Drosten, Christian, Schaade, Lars, Wieler, Lothar H, Lampert, Thomas, Albrecht, Stefan, Born, Sabine, Butschalowsky, Hans, Buttmann-Schweiger, Nina, Damerow, Stefan, Ellert, Ute, Fiebig, Julia, Franke, Andrea, Gräf, Julian, Gundlach, Jasmin, Hey, Isabell, Hinck, Sebastian, Hintze, Marcel, Hölling, Heike, Houben, Robin, Hüther, Antje, Krugmann, Melanie, Kubisch, Ulrike, Kuhnert, Ronny, Kuttig, Tim A., Lange, Michael, Meisegeier, Stefan, Müters, Stephan, Offergeld, Ruth, Perlitz, Hanna, Poethko-Müller, Christina, Pöplow do Rego, Ute, Prütz, Franziska, Sandoni, Anna, Sarganas, Giselle, Schöne, Gina, Stahlberg, Silke, Strandmark, Julia, Thamm, Roma, Vogelgesang, Felicitas, Wachtler, Benjamin, Wernitz, Jörg, Wetzstein, Matthias, Wolff, Christin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2020
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7693167/
https://www.ncbi.nlm.nih.gov/pubmed/33243353
http://dx.doi.org/10.2807/1560-7917.ES.2020.25.47.2001752
Descripción
Sumario:Three months after a coronavirus disease (COVID-19) outbreak in Kupferzell, Germany, a population-based study (n = 2,203) found no RT-PCR-positives. IgG-ELISA seropositivity with positive virus neutralisation tests was 7.7% (95% confidence interval (CI): 6.5–9.1) and 4.3% with negative neutralisation tests. We estimate 12.0% (95% CI: 10.4–14.0%) infected adults (24.5% asymptomatic), six times more than notified. Full hotspot containment confirms the effectiveness of prompt protection measures. However, 88% naïve adults are still at high COVID-19 risk.

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