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Serology- and PCR-based cumulative incidence of SARS-CoV-2 infection in adults in a successfully contained early hotspot (CoMoLo study), Germany, May to June 2020
Three months after a coronavirus disease (COVID-19) outbreak in Kupferzell, Germany, a population-based study (n = 2,203) found no RT-PCR-positives. IgG-ELISA seropositivity with positive virus neutralisation tests was 7.7% (95% confidence interval (CI): 6.5–9.1) and 4.3% with negative neutralisatio...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
European Centre for Disease Prevention and Control (ECDC)
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7693167/ https://www.ncbi.nlm.nih.gov/pubmed/33243353 http://dx.doi.org/10.2807/1560-7917.ES.2020.25.47.2001752 |
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| author | Santos-Hövener, Claudia Neuhauser, Hannelore K Rosario, Angelika Schaffrath Busch, Markus Schlaud, Martin Hoffmann, Robert Gößwald, Antje Koschollek, Carmen Hoebel, Jens Allen, Jennifer Haack-Erdmann, Antje Brockmann, Stefan Ziese, Thomas Nitsche, Andreas Michel, Janine Haller, Sebastian Wilking, Hendrik Hamouda, Osamah Corman, Victor M Drosten, Christian Schaade, Lars Wieler, Lothar H Lampert, Thomas Albrecht, Stefan Born, Sabine Butschalowsky, Hans Buttmann-Schweiger, Nina Damerow, Stefan Ellert, Ute Fiebig, Julia Franke, Andrea Gräf, Julian Gundlach, Jasmin Hey, Isabell Hinck, Sebastian Hintze, Marcel Hölling, Heike Houben, Robin Hüther, Antje Krugmann, Melanie Kubisch, Ulrike Kuhnert, Ronny Kuttig, Tim A. Lange, Michael Meisegeier, Stefan Müters, Stephan Offergeld, Ruth Perlitz, Hanna Poethko-Müller, Christina Pöplow do Rego, Ute Prütz, Franziska Sandoni, Anna Sarganas, Giselle Schöne, Gina Stahlberg, Silke Strandmark, Julia Thamm, Roma Vogelgesang, Felicitas Wachtler, Benjamin Wernitz, Jörg Wetzstein, Matthias Wolff, Christin |
| author_facet | Santos-Hövener, Claudia Neuhauser, Hannelore K Rosario, Angelika Schaffrath Busch, Markus Schlaud, Martin Hoffmann, Robert Gößwald, Antje Koschollek, Carmen Hoebel, Jens Allen, Jennifer Haack-Erdmann, Antje Brockmann, Stefan Ziese, Thomas Nitsche, Andreas Michel, Janine Haller, Sebastian Wilking, Hendrik Hamouda, Osamah Corman, Victor M Drosten, Christian Schaade, Lars Wieler, Lothar H Lampert, Thomas Albrecht, Stefan Born, Sabine Butschalowsky, Hans Buttmann-Schweiger, Nina Damerow, Stefan Ellert, Ute Fiebig, Julia Franke, Andrea Gräf, Julian Gundlach, Jasmin Hey, Isabell Hinck, Sebastian Hintze, Marcel Hölling, Heike Houben, Robin Hüther, Antje Krugmann, Melanie Kubisch, Ulrike Kuhnert, Ronny Kuttig, Tim A. Lange, Michael Meisegeier, Stefan Müters, Stephan Offergeld, Ruth Perlitz, Hanna Poethko-Müller, Christina Pöplow do Rego, Ute Prütz, Franziska Sandoni, Anna Sarganas, Giselle Schöne, Gina Stahlberg, Silke Strandmark, Julia Thamm, Roma Vogelgesang, Felicitas Wachtler, Benjamin Wernitz, Jörg Wetzstein, Matthias Wolff, Christin |
| author_sort | Santos-Hövener, Claudia |
| collection | PubMed |
| description | Three months after a coronavirus disease (COVID-19) outbreak in Kupferzell, Germany, a population-based study (n = 2,203) found no RT-PCR-positives. IgG-ELISA seropositivity with positive virus neutralisation tests was 7.7% (95% confidence interval (CI): 6.5–9.1) and 4.3% with negative neutralisation tests. We estimate 12.0% (95% CI: 10.4–14.0%) infected adults (24.5% asymptomatic), six times more than notified. Full hotspot containment confirms the effectiveness of prompt protection measures. However, 88% naïve adults are still at high COVID-19 risk. |
| format | Online Article Text |
| id | pubmed-7693167 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | European Centre for Disease Prevention and Control (ECDC) |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-76931672020-12-02 Serology- and PCR-based cumulative incidence of SARS-CoV-2 infection in adults in a successfully contained early hotspot (CoMoLo study), Germany, May to June 2020 Santos-Hövener, Claudia Neuhauser, Hannelore K Rosario, Angelika Schaffrath Busch, Markus Schlaud, Martin Hoffmann, Robert Gößwald, Antje Koschollek, Carmen Hoebel, Jens Allen, Jennifer Haack-Erdmann, Antje Brockmann, Stefan Ziese, Thomas Nitsche, Andreas Michel, Janine Haller, Sebastian Wilking, Hendrik Hamouda, Osamah Corman, Victor M Drosten, Christian Schaade, Lars Wieler, Lothar H Lampert, Thomas Albrecht, Stefan Born, Sabine Butschalowsky, Hans Buttmann-Schweiger, Nina Damerow, Stefan Ellert, Ute Fiebig, Julia Franke, Andrea Gräf, Julian Gundlach, Jasmin Hey, Isabell Hinck, Sebastian Hintze, Marcel Hölling, Heike Houben, Robin Hüther, Antje Krugmann, Melanie Kubisch, Ulrike Kuhnert, Ronny Kuttig, Tim A. Lange, Michael Meisegeier, Stefan Müters, Stephan Offergeld, Ruth Perlitz, Hanna Poethko-Müller, Christina Pöplow do Rego, Ute Prütz, Franziska Sandoni, Anna Sarganas, Giselle Schöne, Gina Stahlberg, Silke Strandmark, Julia Thamm, Roma Vogelgesang, Felicitas Wachtler, Benjamin Wernitz, Jörg Wetzstein, Matthias Wolff, Christin Euro Surveill Rapid Communication Three months after a coronavirus disease (COVID-19) outbreak in Kupferzell, Germany, a population-based study (n = 2,203) found no RT-PCR-positives. IgG-ELISA seropositivity with positive virus neutralisation tests was 7.7% (95% confidence interval (CI): 6.5–9.1) and 4.3% with negative neutralisation tests. We estimate 12.0% (95% CI: 10.4–14.0%) infected adults (24.5% asymptomatic), six times more than notified. Full hotspot containment confirms the effectiveness of prompt protection measures. However, 88% naïve adults are still at high COVID-19 risk. European Centre for Disease Prevention and Control (ECDC) 2020-11-26 /pmc/articles/PMC7693167/ /pubmed/33243353 http://dx.doi.org/10.2807/1560-7917.ES.2020.25.47.2001752 Text en This article is copyright of the authors or their affiliated institutions, 2020. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made. |
| spellingShingle | Rapid Communication Santos-Hövener, Claudia Neuhauser, Hannelore K Rosario, Angelika Schaffrath Busch, Markus Schlaud, Martin Hoffmann, Robert Gößwald, Antje Koschollek, Carmen Hoebel, Jens Allen, Jennifer Haack-Erdmann, Antje Brockmann, Stefan Ziese, Thomas Nitsche, Andreas Michel, Janine Haller, Sebastian Wilking, Hendrik Hamouda, Osamah Corman, Victor M Drosten, Christian Schaade, Lars Wieler, Lothar H Lampert, Thomas Albrecht, Stefan Born, Sabine Butschalowsky, Hans Buttmann-Schweiger, Nina Damerow, Stefan Ellert, Ute Fiebig, Julia Franke, Andrea Gräf, Julian Gundlach, Jasmin Hey, Isabell Hinck, Sebastian Hintze, Marcel Hölling, Heike Houben, Robin Hüther, Antje Krugmann, Melanie Kubisch, Ulrike Kuhnert, Ronny Kuttig, Tim A. Lange, Michael Meisegeier, Stefan Müters, Stephan Offergeld, Ruth Perlitz, Hanna Poethko-Müller, Christina Pöplow do Rego, Ute Prütz, Franziska Sandoni, Anna Sarganas, Giselle Schöne, Gina Stahlberg, Silke Strandmark, Julia Thamm, Roma Vogelgesang, Felicitas Wachtler, Benjamin Wernitz, Jörg Wetzstein, Matthias Wolff, Christin Serology- and PCR-based cumulative incidence of SARS-CoV-2 infection in adults in a successfully contained early hotspot (CoMoLo study), Germany, May to June 2020 |
| title | Serology- and PCR-based cumulative incidence of SARS-CoV-2 infection in adults in a successfully contained early hotspot (CoMoLo study), Germany, May to June 2020 |
| title_full | Serology- and PCR-based cumulative incidence of SARS-CoV-2 infection in adults in a successfully contained early hotspot (CoMoLo study), Germany, May to June 2020 |
| title_fullStr | Serology- and PCR-based cumulative incidence of SARS-CoV-2 infection in adults in a successfully contained early hotspot (CoMoLo study), Germany, May to June 2020 |
| title_full_unstemmed | Serology- and PCR-based cumulative incidence of SARS-CoV-2 infection in adults in a successfully contained early hotspot (CoMoLo study), Germany, May to June 2020 |
| title_short | Serology- and PCR-based cumulative incidence of SARS-CoV-2 infection in adults in a successfully contained early hotspot (CoMoLo study), Germany, May to June 2020 |
| title_sort | serology- and pcr-based cumulative incidence of sars-cov-2 infection in adults in a successfully contained early hotspot (comolo study), germany, may to june 2020 |
| topic | Rapid Communication |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7693167/ https://www.ncbi.nlm.nih.gov/pubmed/33243353 http://dx.doi.org/10.2807/1560-7917.ES.2020.25.47.2001752 |
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