Cargando…

Reducing Agent‐Mediated Nonenzymatic Conversion of 2‐Oxoglutarate to Succinate: Implications for Oxygenase Assays

l‐Ascorbate (l‐Asc) is often added to assays with isolated Fe(II)‐ and 2‐oxoglutarate (2OG)‐dependent oxygenases to enhance activity. l‐Asc is proposed to be important in catalysis by some 2OG oxygenases in vivo. We report observations on the nonenzymatic conversion of 2OG to succinate, which is med...

Descripción completa

Detalles Bibliográficos
Autores principales:	Khan, Amjad, Schofield, Christopher J., Claridge, Timothy D. W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7693218/ https://www.ncbi.nlm.nih.gov/pubmed/32478965 http://dx.doi.org/10.1002/cbic.202000185

Ejemplares similares

Non-enzymatic chemistry enables 2-hydroxyglutarate-mediated activation of 2-oxoglutarate oxygenases
por: Tarhonskaya, Hanna, et al.
Publicado: (2014)

Protein Hydroxylation Catalyzed by 2-Oxoglutarate-dependent Oxygenases
por: Markolovic, Suzana, et al.
Publicado: (2015)

Biochemical and structural investigations clarify the substrate selectivity of the 2-oxoglutarate oxygenase JMJD6
por: Islam, Md. Saiful, et al.
Publicado: (2019)

Exploring links between 2‐oxoglutarate‐dependent oxygenases and Alzheimer's disease
por: Liu, Haotian, et al.
Publicado: (2022)

2-Oxoglutarate derivatives can selectively enhance or inhibit the activity of human oxygenases
por: Nakashima, Yu, et al.
Publicado: (2021)

Roles of 2-oxoglutarate oxygenases and isopenicillin N synthase in β-lactam biosynthesis
por: Rabe, Patrick, et al.
Publicado: (2018)

Structural analysis of the 2-oxoglutarate binding site of the circadian rhythm linked oxygenase JMJD5
por: Islam, Md. Saiful, et al.
Publicado: (2022)

Fluorinated derivatives of pyridine-2,4-dicarboxylate are potent inhibitors of human 2-oxoglutarate dependent oxygenases
por: Brewitz, Lennart, et al.
Publicado: (2021)

Human 2-oxoglutarate-dependent oxygenases: nutrient sensors, stress responders, and disease mediators
por: Fletcher, Sally C., et al.
Publicado: (2020)

The Function and Catalysis of 2-Oxoglutarate-Dependent Oxygenases Involved in Plant Flavonoid Biosynthesis
por: Cheng, Ai-Xia, et al.
Publicado: (2014)

Role of Structural Dynamics in Selectivity and Mechanism of Non-heme Fe(II) and 2-Oxoglutarate-Dependent Oxygenases Involved in DNA Repair
por: Waheed, Sodiq O., et al.
Publicado: (2020)

Identification of Disease-Related 2-Oxoglutarate/Fe (II)-Dependent Oxygenase Based on Reduced Amino Acid Cluster Strategy
por: Zhou, Jian, et al.
Publicado: (2021)

Dual prognostic role of 2-oxoglutarate-dependent oxygenases in ten cancer types: implications for cell cycle regulation and cell adhesion maintenance
por: Chang, Wai Hoong, et al.
Publicado: (2019)

MDIG, a 2-oxoglutarate-dependent oxygenase, acts as an oncogene and predicts the prognosis of multiple types of cancer
por: Geng, Feng, et al.
Publicado: (2022)

2-Oxoglutarate regulates binding of hydroxylated hypoxia-inducible factor to prolyl hydroxylase domain 2
por: Abboud, Martine I., et al.
Publicado: (2018)

Inhibition of JMJD6 by 2‐Oxoglutarate Mimics
por: Islam, Md. Sailful, et al.
Publicado: (2021)

Is JmjC Oxygenase Catalysis Limited to Demethylation?**
por: Hopkinson, Richard J, et al.
Publicado: (2013)

A comprehensive review on the determination of enzymatic assay and nonenzymatic antioxidant activities
por: Haida, Zainol, et al.
Publicado: (2019)

Oxygenase-Catalyzed Desymmetrization of N,N-Dialkyl-piperidine-4-carboxylic Acids**
por: Rydzik, Anna M, et al.
Publicado: (2014)

Human AlkB Homologue 5 Is a Nuclear 2-Oxoglutarate Dependent Oxygenase and a Direct Target of Hypoxia-Inducible Factor 1α (HIF-1α)
por: Thalhammer, Armin, et al.
Publicado: (2011)

Behavioral Impact of the Regulation of the Brain 2-Oxoglutarate Dehydrogenase Complex by Synthetic Phosphonate Analog of 2-Oxoglutarate: Implications into the Role of the Complex in Neurodegenerative Diseases
por: Trofimova, L., et al.
Publicado: (2010)

Oxoglutarate Carrier Inhibition Reduced Melanoma Growth and Invasion by Reducing ATP Production
por: Lee, Jae-Seon, et al.
Publicado: (2020)

Installation of the Ether Bridge of Lolines by the Iron- and 2-Oxoglutarate-Dependent Oxygenase, LolO: Regio- and Stereochemistry of Sequential Hydroxylation and Oxacyclization Reactions
por: Pan, Juan, et al.
Publicado: (2018)

A nonenzymatic reduced graphene oxide-based nanosensor for parathion
por: Sen, Sarani, et al.
Publicado: (2022)

Oxoglutarate dehydrogenase complex controls glutamate-mediated neuronal death
por: Weidinger, Adelheid, et al.
Publicado: (2023)

Synthesis of 2-oxoglutarate derivatives and their evaluation as cosubstrates and inhibitors of human aspartate/asparagine-β-hydroxylase
por: Brewitz, Lennart, et al.
Publicado: (2020)

ABHD11 maintains 2-oxoglutarate metabolism by preserving functional lipoylation of the 2-oxoglutarate dehydrogenase complex
por: Bailey, Peter S. J., et al.
Publicado: (2020)

N-Phenacylthiazolium Bromide Reduces Bone Fragility Induced by Nonenzymatic Glycation
por: Bradke, Brian S., et al.
Publicado: (2014)

The 2-oxoglutarate analog 3-oxoglutarate decreases normoxic hypoxia-inducible factor-1α in cancer cells, induces cell death, and reduces tumor xenograft growth
por: Koivunen, Peppi, et al.
Publicado: (2016)

Classification of Nonenzymatic Homologues of Protein Kinases
por: Anamika, K., et al.
Publicado: (2009)

Quantitative MS‐Based Proteomics: Comparing the MCF‐7 Cellular Response to Hypoxia and a 2‐Oxoglutarate Analogue
por: Bush, Jacob T., et al.
Publicado: (2020)

Synthesis of [3,3-(2)H(2)]-Dihydroartemisinic Acid to Measure the Rate of Nonenzymatic Conversion of Dihydroartemisinic Acid to Artemisinin
por: Varela, Kaitlyn, et al.
Publicado: (2019)

A NiFe Alloy Reduced on Graphene Oxide for Electrochemical Nonenzymatic Glucose Sensing
por: Deng, Zhe-Peng, et al.
Publicado: (2018)

Site-Specific Reactivity of Nonenzymatic Lysine Acetylation
por: Baeza, Josue, et al.
Publicado: (2015)

Inhibition of nonenzymatic depurination of nucleic acids by polycations
por: An, Ran, et al.
Publicado: (2017)

Crystallographic observation of nonenzymatic RNA primer extension
por: Zhang, Wen, et al.
Publicado: (2018)

A Nonenzymatic Analog of Pyrimidine Nucleobase Biosynthesis
por: Yi, Jing, et al.
Publicado: (2022)

Development of a Nonenzymatic Colorimetric Sensor for the Detection of Uric Acid Based on Ionic Liquid-Mediated Nickel Nanostructures
por: Nishan, Umar, et al.
Publicado: (2022)

Detailed kinetics and regulation of mammalian 2-oxoglutarate dehydrogenase
por: Qi, Feng, et al.
Publicado: (2011)

2-Oxoglutarate-dependent dioxygenases in the biosynthesis of simple coumarins
por: Shimizu, Bun-Ichi
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_9hjusd5a9nsel48k6qdershkvi