Cargando…
Abnormal Nailfold Capillaries in Patients after Hand Transplantation
Background: The development of graft vasculopathy may play a role in the long-term deterioration of hand grafts. The aim of study was to examine the patterns of the nailfold capillaries in hand transplant recipients. Methods: the study was performed on six patients who received hand transplantation....
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7693261/ https://www.ncbi.nlm.nih.gov/pubmed/33113869 http://dx.doi.org/10.3390/jcm9113422 |
_version_ | 1783614703215312896 |
---|---|
author | Sikorska, Dorota Samborski, Włodzimierz Kamińska, Dorota Kusztal, Mariusz Jabłecki, Jerzy Nijakowski, Kacper Oko, Andrzej Karczewski, Marek Korybalska, Katarzyna Witowski, Janusz |
author_facet | Sikorska, Dorota Samborski, Włodzimierz Kamińska, Dorota Kusztal, Mariusz Jabłecki, Jerzy Nijakowski, Kacper Oko, Andrzej Karczewski, Marek Korybalska, Katarzyna Witowski, Janusz |
author_sort | Sikorska, Dorota |
collection | PubMed |
description | Background: The development of graft vasculopathy may play a role in the long-term deterioration of hand grafts. The aim of study was to examine the patterns of the nailfold capillaries in hand transplant recipients. Methods: the study was performed on six patients who received hand transplantation. To normalize for the effect of immunosuppression an age- and sex-matched group of 12 patients with active kidney transplant was selected. As an additional control group, 12 healthy volunteers were recruited. Nailfold videocapillaroscopy was performed in all participants. Additionally, serum concentrations of vascular endothelial growth factor (VEGF) were measured. Results: Videocapillaroscopic examination of the hand allografts revealed significant abnormalities: including capillary disorganization and microhaemorrhages. The number of capillaries was reduced, the vessels were enlarged and branched. Surprisingly, similar, albeit slightly less pronounced, changes were seen in the nailfolds of healthy hands of the limb transplant recipients. In kidney transplant recipients the capillaroscopic pattern was general normal and comparable to healthy individuals. Moreover, serum concentrations of VEGF in all participants correlated with average capillary diameter in capillaroscopy. Conclusions: in hand transplant recipients advanced microvascular abnormalities are found in nailfold capillaroscopic pattern in both transplanted and own extremities connected with elevated levels of VEGF. |
format | Online Article Text |
id | pubmed-7693261 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-76932612020-11-28 Abnormal Nailfold Capillaries in Patients after Hand Transplantation Sikorska, Dorota Samborski, Włodzimierz Kamińska, Dorota Kusztal, Mariusz Jabłecki, Jerzy Nijakowski, Kacper Oko, Andrzej Karczewski, Marek Korybalska, Katarzyna Witowski, Janusz J Clin Med Article Background: The development of graft vasculopathy may play a role in the long-term deterioration of hand grafts. The aim of study was to examine the patterns of the nailfold capillaries in hand transplant recipients. Methods: the study was performed on six patients who received hand transplantation. To normalize for the effect of immunosuppression an age- and sex-matched group of 12 patients with active kidney transplant was selected. As an additional control group, 12 healthy volunteers were recruited. Nailfold videocapillaroscopy was performed in all participants. Additionally, serum concentrations of vascular endothelial growth factor (VEGF) were measured. Results: Videocapillaroscopic examination of the hand allografts revealed significant abnormalities: including capillary disorganization and microhaemorrhages. The number of capillaries was reduced, the vessels were enlarged and branched. Surprisingly, similar, albeit slightly less pronounced, changes were seen in the nailfolds of healthy hands of the limb transplant recipients. In kidney transplant recipients the capillaroscopic pattern was general normal and comparable to healthy individuals. Moreover, serum concentrations of VEGF in all participants correlated with average capillary diameter in capillaroscopy. Conclusions: in hand transplant recipients advanced microvascular abnormalities are found in nailfold capillaroscopic pattern in both transplanted and own extremities connected with elevated levels of VEGF. MDPI 2020-10-25 /pmc/articles/PMC7693261/ /pubmed/33113869 http://dx.doi.org/10.3390/jcm9113422 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Sikorska, Dorota Samborski, Włodzimierz Kamińska, Dorota Kusztal, Mariusz Jabłecki, Jerzy Nijakowski, Kacper Oko, Andrzej Karczewski, Marek Korybalska, Katarzyna Witowski, Janusz Abnormal Nailfold Capillaries in Patients after Hand Transplantation |
title | Abnormal Nailfold Capillaries in Patients after Hand Transplantation |
title_full | Abnormal Nailfold Capillaries in Patients after Hand Transplantation |
title_fullStr | Abnormal Nailfold Capillaries in Patients after Hand Transplantation |
title_full_unstemmed | Abnormal Nailfold Capillaries in Patients after Hand Transplantation |
title_short | Abnormal Nailfold Capillaries in Patients after Hand Transplantation |
title_sort | abnormal nailfold capillaries in patients after hand transplantation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7693261/ https://www.ncbi.nlm.nih.gov/pubmed/33113869 http://dx.doi.org/10.3390/jcm9113422 |
work_keys_str_mv | AT sikorskadorota abnormalnailfoldcapillariesinpatientsafterhandtransplantation AT samborskiwłodzimierz abnormalnailfoldcapillariesinpatientsafterhandtransplantation AT kaminskadorota abnormalnailfoldcapillariesinpatientsafterhandtransplantation AT kusztalmariusz abnormalnailfoldcapillariesinpatientsafterhandtransplantation AT jabłeckijerzy abnormalnailfoldcapillariesinpatientsafterhandtransplantation AT nijakowskikacper abnormalnailfoldcapillariesinpatientsafterhandtransplantation AT okoandrzej abnormalnailfoldcapillariesinpatientsafterhandtransplantation AT karczewskimarek abnormalnailfoldcapillariesinpatientsafterhandtransplantation AT korybalskakatarzyna abnormalnailfoldcapillariesinpatientsafterhandtransplantation AT witowskijanusz abnormalnailfoldcapillariesinpatientsafterhandtransplantation |