p53 Loss Mediates Hypersensitivity to ETS Transcription Factor Inhibition Based on PARylation-Mediated Cell Death Induction

SIMPLE SUMMARY: ETS transcription factors are potent oncogenic drivers in several cancer types and represent promising therapeutic targets. However, molecular factors influencing response to ETS factor inhibition are widely unknown so far. Here, we uncover that sensitivity of cancer cells against ET...

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Detalles Bibliográficos
Autores principales: Dinhof, Carina, Pirker, Christine, Kroiss, Philipp, Kirchhofer, Dominik, Gabler, Lisa, Gojo, Johannes, Lötsch-Gojo, Daniela, Stojanovic, Mirjana, Timelthaler, Gerald, Ferk, Franziska, Knasmüller, Siegfried, Reisecker, Johannes, Spiegl-Kreinecker, Sabine, Birner, Peter, Preusser, Matthias, Berger, Walter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7693367/
https://www.ncbi.nlm.nih.gov/pubmed/33143299
http://dx.doi.org/10.3390/cancers12113205

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