The Oral Glucose Tolerance Test—Is It Time for a Change?—A Literature Review with an Emphasis on Pregnancy

Globally, gestational diabetes (GDM) is increasing at an alarming rate. This increase is linked to the rise in obesity rates among women of reproductive age. GDM poses a major global health problem due to the related micro- and macro-vascular complications of subsequent Type 2 diabetes and the impac...

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Autores principales: Bogdanet, Delia, O’Shea, Paula, Lyons, Claire, Shafat, Amir, Dunne, Fidelma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7693369/
https://www.ncbi.nlm.nih.gov/pubmed/33121014
http://dx.doi.org/10.3390/jcm9113451
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author Bogdanet, Delia
O’Shea, Paula
Lyons, Claire
Shafat, Amir
Dunne, Fidelma
author_facet Bogdanet, Delia
O’Shea, Paula
Lyons, Claire
Shafat, Amir
Dunne, Fidelma
author_sort Bogdanet, Delia
collection PubMed
description Globally, gestational diabetes (GDM) is increasing at an alarming rate. This increase is linked to the rise in obesity rates among women of reproductive age. GDM poses a major global health problem due to the related micro- and macro-vascular complications of subsequent Type 2 diabetes and the impact on the future health of generations through the long-term impact of GDM on both mothers and their infants. Therefore, correctly identifying subjects as having GDM is of utmost importance. The oral glucose tolerance test (OGTT) has been the mainstay for diagnosing gestational diabetes for decades. However, this test is deeply flawed. In this review, we explore a history of the OGTT, its reproducibility and the many factors that can impact its results with an emphasis on pregnancy.
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spelling pubmed-76933692020-11-28 The Oral Glucose Tolerance Test—Is It Time for a Change?—A Literature Review with an Emphasis on Pregnancy Bogdanet, Delia O’Shea, Paula Lyons, Claire Shafat, Amir Dunne, Fidelma J Clin Med Review Globally, gestational diabetes (GDM) is increasing at an alarming rate. This increase is linked to the rise in obesity rates among women of reproductive age. GDM poses a major global health problem due to the related micro- and macro-vascular complications of subsequent Type 2 diabetes and the impact on the future health of generations through the long-term impact of GDM on both mothers and their infants. Therefore, correctly identifying subjects as having GDM is of utmost importance. The oral glucose tolerance test (OGTT) has been the mainstay for diagnosing gestational diabetes for decades. However, this test is deeply flawed. In this review, we explore a history of the OGTT, its reproducibility and the many factors that can impact its results with an emphasis on pregnancy. MDPI 2020-10-27 /pmc/articles/PMC7693369/ /pubmed/33121014 http://dx.doi.org/10.3390/jcm9113451 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bogdanet, Delia
O’Shea, Paula
Lyons, Claire
Shafat, Amir
Dunne, Fidelma
The Oral Glucose Tolerance Test—Is It Time for a Change?—A Literature Review with an Emphasis on Pregnancy
title The Oral Glucose Tolerance Test—Is It Time for a Change?—A Literature Review with an Emphasis on Pregnancy
title_full The Oral Glucose Tolerance Test—Is It Time for a Change?—A Literature Review with an Emphasis on Pregnancy
title_fullStr The Oral Glucose Tolerance Test—Is It Time for a Change?—A Literature Review with an Emphasis on Pregnancy
title_full_unstemmed The Oral Glucose Tolerance Test—Is It Time for a Change?—A Literature Review with an Emphasis on Pregnancy
title_short The Oral Glucose Tolerance Test—Is It Time for a Change?—A Literature Review with an Emphasis on Pregnancy
title_sort oral glucose tolerance test—is it time for a change?—a literature review with an emphasis on pregnancy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7693369/
https://www.ncbi.nlm.nih.gov/pubmed/33121014
http://dx.doi.org/10.3390/jcm9113451
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