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The Influence of Gender in The Prognostic Impact of Diabetes mellitus in acute Pulmonary Embolism

Diabetes mellitus (DM) predicts ominous outcomes in acute pulmonary embolism (PE). The influence of gender on the prognostic impact of DM in PE is unknown. We did a retrospective analysis of a cohort of patients hospitalized with PE between 2006 and 2013. The exclusion criteria were age <18, non-...

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Autores principales: Oliveira, Diana, Brito, Teresa, Elias, Catarina, Carreira, Marta, Serino, Mariana, Guerreiro, Inês, Magalhães, Helena, Coelho, Sara, Ferreira, Sara, Araújo, Emanuel, Ribeiro, Ana, Lourenço, Patrícia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7693483/
https://www.ncbi.nlm.nih.gov/pubmed/33142963
http://dx.doi.org/10.3390/jcm9113511
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author Oliveira, Diana
Brito, Teresa
Elias, Catarina
Carreira, Marta
Serino, Mariana
Guerreiro, Inês
Magalhães, Helena
Coelho, Sara
Ferreira, Sara
Araújo, Emanuel
Ribeiro, Ana
Lourenço, Patrícia
author_facet Oliveira, Diana
Brito, Teresa
Elias, Catarina
Carreira, Marta
Serino, Mariana
Guerreiro, Inês
Magalhães, Helena
Coelho, Sara
Ferreira, Sara
Araújo, Emanuel
Ribeiro, Ana
Lourenço, Patrícia
author_sort Oliveira, Diana
collection PubMed
description Diabetes mellitus (DM) predicts ominous outcomes in acute pulmonary embolism (PE). The influence of gender on the prognostic impact of DM in PE is unknown. We did a retrospective analysis of a cohort of patients hospitalized with PE between 2006 and 2013. The exclusion criteria were age <18, non-pulmonary veins thromboembolism, recurrent PE, chronic thromboembolic pulmonary hypertension, no radiologic confirmation of PE, and active neoplasia. The primary endpoint was all-cause mortality. The follow-up was from diagnosis until October 2017. We assessed the prognostic impact of DM using a multivariate Cox regression analysis. The analysis was stratified according to gender. The interaction between gender and DM in the outcome of patients with PE was tested. We studied 577 PE patients (median age 65 years, 36.9% men, 19.8% diabetic). The genders were similar regarding the prevalence of DM, the extension and location of PE, and the thrombolytic therapy or brain natriuretic peptide (BNP) value. Diabetics presented higher all-cause mortality (Hazard ratio (HR) = 2.33 (95% confidence Interval (CI) 1.513.61)) when compared with non-diabetics. However, when analysis was stratified according to gender, DM was independently associated with a worse prognosis only in women (HR = 2.31 (95% CI 1.453.65)), while in men the HR was 1.10 (95% CI 0.592.04). The interaction between gender and DM was significant (p = 0.04). Gender influences the prognostic impact of DM in acute PE. Diabetic women with PE have twice the long-term mortality risk, while DM is not mortality-associated in men.
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spelling pubmed-76934832020-11-28 The Influence of Gender in The Prognostic Impact of Diabetes mellitus in acute Pulmonary Embolism Oliveira, Diana Brito, Teresa Elias, Catarina Carreira, Marta Serino, Mariana Guerreiro, Inês Magalhães, Helena Coelho, Sara Ferreira, Sara Araújo, Emanuel Ribeiro, Ana Lourenço, Patrícia J Clin Med Article Diabetes mellitus (DM) predicts ominous outcomes in acute pulmonary embolism (PE). The influence of gender on the prognostic impact of DM in PE is unknown. We did a retrospective analysis of a cohort of patients hospitalized with PE between 2006 and 2013. The exclusion criteria were age <18, non-pulmonary veins thromboembolism, recurrent PE, chronic thromboembolic pulmonary hypertension, no radiologic confirmation of PE, and active neoplasia. The primary endpoint was all-cause mortality. The follow-up was from diagnosis until October 2017. We assessed the prognostic impact of DM using a multivariate Cox regression analysis. The analysis was stratified according to gender. The interaction between gender and DM in the outcome of patients with PE was tested. We studied 577 PE patients (median age 65 years, 36.9% men, 19.8% diabetic). The genders were similar regarding the prevalence of DM, the extension and location of PE, and the thrombolytic therapy or brain natriuretic peptide (BNP) value. Diabetics presented higher all-cause mortality (Hazard ratio (HR) = 2.33 (95% confidence Interval (CI) 1.513.61)) when compared with non-diabetics. However, when analysis was stratified according to gender, DM was independently associated with a worse prognosis only in women (HR = 2.31 (95% CI 1.453.65)), while in men the HR was 1.10 (95% CI 0.592.04). The interaction between gender and DM was significant (p = 0.04). Gender influences the prognostic impact of DM in acute PE. Diabetic women with PE have twice the long-term mortality risk, while DM is not mortality-associated in men. MDPI 2020-10-30 /pmc/articles/PMC7693483/ /pubmed/33142963 http://dx.doi.org/10.3390/jcm9113511 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Oliveira, Diana
Brito, Teresa
Elias, Catarina
Carreira, Marta
Serino, Mariana
Guerreiro, Inês
Magalhães, Helena
Coelho, Sara
Ferreira, Sara
Araújo, Emanuel
Ribeiro, Ana
Lourenço, Patrícia
The Influence of Gender in The Prognostic Impact of Diabetes mellitus in acute Pulmonary Embolism
title The Influence of Gender in The Prognostic Impact of Diabetes mellitus in acute Pulmonary Embolism
title_full The Influence of Gender in The Prognostic Impact of Diabetes mellitus in acute Pulmonary Embolism
title_fullStr The Influence of Gender in The Prognostic Impact of Diabetes mellitus in acute Pulmonary Embolism
title_full_unstemmed The Influence of Gender in The Prognostic Impact of Diabetes mellitus in acute Pulmonary Embolism
title_short The Influence of Gender in The Prognostic Impact of Diabetes mellitus in acute Pulmonary Embolism
title_sort influence of gender in the prognostic impact of diabetes mellitus in acute pulmonary embolism
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7693483/
https://www.ncbi.nlm.nih.gov/pubmed/33142963
http://dx.doi.org/10.3390/jcm9113511
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