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Impact on Prognosis of the Surgical Route, Laparoscopy or Laparotomy, for the Surgical Staging of Early Stage Ovarian Cancer—A Study from the FRANCOGYN Group

Background and objective: according to the latest ESMO−ESGO recommendations, laparotomy is the standard surgical approach to treat and stage patients with presumed early stage epithelial ovarian cancer (EOC). A few studies have investigated the efficacy and the safety of laparoscopy for the staging...

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Autores principales: Merlier, Margaux, Kerbage, Yohan, Pierache, Adeline, Ramdane, Nassima, Canlorbe, Geoffroy, Bolze, Pierre-Adrien, Ballester, Marcos, Bendifallah, Sofiane, Ouldamer, Lobna, Touboul, Cyril, Huchon, Cyrille, Lavoue, Vincent, Dabi, Yohann, Akladios, Cherik, Coutant, Charles, Raimond, Emilie, Bricou, Alexandre, Phalippou, Jerôme, Collinet, Pierre, Azaïs, Henri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7693611/
https://www.ncbi.nlm.nih.gov/pubmed/33142772
http://dx.doi.org/10.3390/jcm9113528
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author Merlier, Margaux
Kerbage, Yohan
Pierache, Adeline
Ramdane, Nassima
Canlorbe, Geoffroy
Bolze, Pierre-Adrien
Ballester, Marcos
Bendifallah, Sofiane
Ouldamer, Lobna
Touboul, Cyril
Huchon, Cyrille
Lavoue, Vincent
Dabi, Yohann
Akladios, Cherik
Coutant, Charles
Raimond, Emilie
Bricou, Alexandre
Phalippou, Jerôme
Collinet, Pierre
Azaïs, Henri
author_facet Merlier, Margaux
Kerbage, Yohan
Pierache, Adeline
Ramdane, Nassima
Canlorbe, Geoffroy
Bolze, Pierre-Adrien
Ballester, Marcos
Bendifallah, Sofiane
Ouldamer, Lobna
Touboul, Cyril
Huchon, Cyrille
Lavoue, Vincent
Dabi, Yohann
Akladios, Cherik
Coutant, Charles
Raimond, Emilie
Bricou, Alexandre
Phalippou, Jerôme
Collinet, Pierre
Azaïs, Henri
author_sort Merlier, Margaux
collection PubMed
description Background and objective: according to the latest ESMO−ESGO recommendations, laparotomy is the standard surgical approach to treat and stage patients with presumed early stage epithelial ovarian cancer (EOC). A few studies have investigated the efficacy and the safety of laparoscopy for the staging of early stage EOC, and this question is still in the center of debates. Recurrence-free survival (RFS) and overall survival (OS) benefits of the minimally invasive surgery (MIS) have still to be specified. The aim of this multicenter and retrospective study is to assess the survival outcomes of laparoscopic staging in comparison with laparotomic staging for patients presenting with an early stage EOC. Methods: data of patients with early stage EOC (FIGO I-IIA) who underwent primary surgery between 2000 and 2018 were extracted from the FRANCOGYN database. OS and RFS of these two groups, constituted according to the surgical route, were compared using Log rank test. Results: of the 144 patients included, 107 patients underwent laparotomy and 37 underwent laparoscopy for a staging purpose. The median follow-up was 36.0 months (18.0 to 58.0). For the laparoscopy and the laparotomy group, the median follow-up period was 24 (11.0 to 50.0) and 42.0 (24.0 to 66.0) months, respectively, (p < 0.001). Tumor recurrence occurred in 33 (23%) patients: 2 (5.4%) in the laparoscopy group and 31 (29%) in the laparotomy group (p = 0.08). The OS rate at 5 years was 97.3% after laparoscopy and 79.8% after laparotomy (p = 0.19). Conclusions: there is no difference associated with the laparoscopic approach for the staging of early stage EOC on RFS and OS in comparison with laparotomy. MIS may be proposed as a safe and adequate alternative to laparotomy when performed by well-trained surgeons.
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spelling pubmed-76936112020-11-28 Impact on Prognosis of the Surgical Route, Laparoscopy or Laparotomy, for the Surgical Staging of Early Stage Ovarian Cancer—A Study from the FRANCOGYN Group Merlier, Margaux Kerbage, Yohan Pierache, Adeline Ramdane, Nassima Canlorbe, Geoffroy Bolze, Pierre-Adrien Ballester, Marcos Bendifallah, Sofiane Ouldamer, Lobna Touboul, Cyril Huchon, Cyrille Lavoue, Vincent Dabi, Yohann Akladios, Cherik Coutant, Charles Raimond, Emilie Bricou, Alexandre Phalippou, Jerôme Collinet, Pierre Azaïs, Henri J Clin Med Article Background and objective: according to the latest ESMO−ESGO recommendations, laparotomy is the standard surgical approach to treat and stage patients with presumed early stage epithelial ovarian cancer (EOC). A few studies have investigated the efficacy and the safety of laparoscopy for the staging of early stage EOC, and this question is still in the center of debates. Recurrence-free survival (RFS) and overall survival (OS) benefits of the minimally invasive surgery (MIS) have still to be specified. The aim of this multicenter and retrospective study is to assess the survival outcomes of laparoscopic staging in comparison with laparotomic staging for patients presenting with an early stage EOC. Methods: data of patients with early stage EOC (FIGO I-IIA) who underwent primary surgery between 2000 and 2018 were extracted from the FRANCOGYN database. OS and RFS of these two groups, constituted according to the surgical route, were compared using Log rank test. Results: of the 144 patients included, 107 patients underwent laparotomy and 37 underwent laparoscopy for a staging purpose. The median follow-up was 36.0 months (18.0 to 58.0). For the laparoscopy and the laparotomy group, the median follow-up period was 24 (11.0 to 50.0) and 42.0 (24.0 to 66.0) months, respectively, (p < 0.001). Tumor recurrence occurred in 33 (23%) patients: 2 (5.4%) in the laparoscopy group and 31 (29%) in the laparotomy group (p = 0.08). The OS rate at 5 years was 97.3% after laparoscopy and 79.8% after laparotomy (p = 0.19). Conclusions: there is no difference associated with the laparoscopic approach for the staging of early stage EOC on RFS and OS in comparison with laparotomy. MIS may be proposed as a safe and adequate alternative to laparotomy when performed by well-trained surgeons. MDPI 2020-10-31 /pmc/articles/PMC7693611/ /pubmed/33142772 http://dx.doi.org/10.3390/jcm9113528 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Merlier, Margaux
Kerbage, Yohan
Pierache, Adeline
Ramdane, Nassima
Canlorbe, Geoffroy
Bolze, Pierre-Adrien
Ballester, Marcos
Bendifallah, Sofiane
Ouldamer, Lobna
Touboul, Cyril
Huchon, Cyrille
Lavoue, Vincent
Dabi, Yohann
Akladios, Cherik
Coutant, Charles
Raimond, Emilie
Bricou, Alexandre
Phalippou, Jerôme
Collinet, Pierre
Azaïs, Henri
Impact on Prognosis of the Surgical Route, Laparoscopy or Laparotomy, for the Surgical Staging of Early Stage Ovarian Cancer—A Study from the FRANCOGYN Group
title Impact on Prognosis of the Surgical Route, Laparoscopy or Laparotomy, for the Surgical Staging of Early Stage Ovarian Cancer—A Study from the FRANCOGYN Group
title_full Impact on Prognosis of the Surgical Route, Laparoscopy or Laparotomy, for the Surgical Staging of Early Stage Ovarian Cancer—A Study from the FRANCOGYN Group
title_fullStr Impact on Prognosis of the Surgical Route, Laparoscopy or Laparotomy, for the Surgical Staging of Early Stage Ovarian Cancer—A Study from the FRANCOGYN Group
title_full_unstemmed Impact on Prognosis of the Surgical Route, Laparoscopy or Laparotomy, for the Surgical Staging of Early Stage Ovarian Cancer—A Study from the FRANCOGYN Group
title_short Impact on Prognosis of the Surgical Route, Laparoscopy or Laparotomy, for the Surgical Staging of Early Stage Ovarian Cancer—A Study from the FRANCOGYN Group
title_sort impact on prognosis of the surgical route, laparoscopy or laparotomy, for the surgical staging of early stage ovarian cancer—a study from the francogyn group
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7693611/
https://www.ncbi.nlm.nih.gov/pubmed/33142772
http://dx.doi.org/10.3390/jcm9113528
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