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The Y Chromosome: A Complex Locus for Genetic Analyses of Complex Human Traits
The Human Y chromosome (ChrY) has been demonstrated to be a powerful tool for phylogenetics, population genetics, genetic genealogy and forensics. However, the importance of ChrY genetic variation in relation to human complex traits is less clear. In this review, we summarise existing evidence about...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7693691/ https://www.ncbi.nlm.nih.gov/pubmed/33137877 http://dx.doi.org/10.3390/genes11111273 |
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author | Parker, Katherine Erzurumluoglu, A. Mesut Rodriguez, Santiago |
author_facet | Parker, Katherine Erzurumluoglu, A. Mesut Rodriguez, Santiago |
author_sort | Parker, Katherine |
collection | PubMed |
description | The Human Y chromosome (ChrY) has been demonstrated to be a powerful tool for phylogenetics, population genetics, genetic genealogy and forensics. However, the importance of ChrY genetic variation in relation to human complex traits is less clear. In this review, we summarise existing evidence about the inherent complexities of ChrY variation and their use in association studies of human complex traits. We present and discuss the specific particularities of ChrY genetic variation, including Y chromosomal haplogroups, that need to be considered in the design and interpretation of genetic epidemiological studies involving ChrY. |
format | Online Article Text |
id | pubmed-7693691 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-76936912020-11-28 The Y Chromosome: A Complex Locus for Genetic Analyses of Complex Human Traits Parker, Katherine Erzurumluoglu, A. Mesut Rodriguez, Santiago Genes (Basel) Review The Human Y chromosome (ChrY) has been demonstrated to be a powerful tool for phylogenetics, population genetics, genetic genealogy and forensics. However, the importance of ChrY genetic variation in relation to human complex traits is less clear. In this review, we summarise existing evidence about the inherent complexities of ChrY variation and their use in association studies of human complex traits. We present and discuss the specific particularities of ChrY genetic variation, including Y chromosomal haplogroups, that need to be considered in the design and interpretation of genetic epidemiological studies involving ChrY. MDPI 2020-10-29 /pmc/articles/PMC7693691/ /pubmed/33137877 http://dx.doi.org/10.3390/genes11111273 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Parker, Katherine Erzurumluoglu, A. Mesut Rodriguez, Santiago The Y Chromosome: A Complex Locus for Genetic Analyses of Complex Human Traits |
title | The Y Chromosome: A Complex Locus for Genetic Analyses of Complex Human Traits |
title_full | The Y Chromosome: A Complex Locus for Genetic Analyses of Complex Human Traits |
title_fullStr | The Y Chromosome: A Complex Locus for Genetic Analyses of Complex Human Traits |
title_full_unstemmed | The Y Chromosome: A Complex Locus for Genetic Analyses of Complex Human Traits |
title_short | The Y Chromosome: A Complex Locus for Genetic Analyses of Complex Human Traits |
title_sort | y chromosome: a complex locus for genetic analyses of complex human traits |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7693691/ https://www.ncbi.nlm.nih.gov/pubmed/33137877 http://dx.doi.org/10.3390/genes11111273 |
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