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The Role of Sumoylation in the Response to Hypoxia: An Overview

Sumoylation is the covalent attachment of the small ubiquitin-related modifier (SUMO) to a vast variety of proteins in order to modulate their function. Sumoylation has emerged as an important modification with a regulatory role in the cellular response to different types of stress including osmotic...

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Autores principales: Filippopoulou, Chrysa, Simos, George, Chachami, Georgia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7693722/
https://www.ncbi.nlm.nih.gov/pubmed/33114748
http://dx.doi.org/10.3390/cells9112359
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author Filippopoulou, Chrysa
Simos, George
Chachami, Georgia
author_facet Filippopoulou, Chrysa
Simos, George
Chachami, Georgia
author_sort Filippopoulou, Chrysa
collection PubMed
description Sumoylation is the covalent attachment of the small ubiquitin-related modifier (SUMO) to a vast variety of proteins in order to modulate their function. Sumoylation has emerged as an important modification with a regulatory role in the cellular response to different types of stress including osmotic, hypoxic and oxidative stress. Hypoxia can occur under physiological or pathological conditions, such as ischemia and cancer, as a result of an oxygen imbalance caused by low supply and/or increased consumption. The hypoxia inducible factors (HIFs), and the proteins that regulate their fate, are critical molecular mediators of the response to hypoxia and modulate procedures such as glucose and lipid metabolism, angiogenesis, erythropoiesis and, in the case of cancer, tumor progression and metastasis. Here, we provide an overview of the sumoylation-dependent mechanisms that are activated under hypoxia and the way they influence key players of the hypoxic response pathway. As hypoxia is a hallmark of many diseases, understanding the interrelated connections between the SUMO and the hypoxic signaling pathways can open the way for future molecular therapeutic interventions.
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spelling pubmed-76937222020-11-28 The Role of Sumoylation in the Response to Hypoxia: An Overview Filippopoulou, Chrysa Simos, George Chachami, Georgia Cells Review Sumoylation is the covalent attachment of the small ubiquitin-related modifier (SUMO) to a vast variety of proteins in order to modulate their function. Sumoylation has emerged as an important modification with a regulatory role in the cellular response to different types of stress including osmotic, hypoxic and oxidative stress. Hypoxia can occur under physiological or pathological conditions, such as ischemia and cancer, as a result of an oxygen imbalance caused by low supply and/or increased consumption. The hypoxia inducible factors (HIFs), and the proteins that regulate their fate, are critical molecular mediators of the response to hypoxia and modulate procedures such as glucose and lipid metabolism, angiogenesis, erythropoiesis and, in the case of cancer, tumor progression and metastasis. Here, we provide an overview of the sumoylation-dependent mechanisms that are activated under hypoxia and the way they influence key players of the hypoxic response pathway. As hypoxia is a hallmark of many diseases, understanding the interrelated connections between the SUMO and the hypoxic signaling pathways can open the way for future molecular therapeutic interventions. MDPI 2020-10-26 /pmc/articles/PMC7693722/ /pubmed/33114748 http://dx.doi.org/10.3390/cells9112359 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Filippopoulou, Chrysa
Simos, George
Chachami, Georgia
The Role of Sumoylation in the Response to Hypoxia: An Overview
title The Role of Sumoylation in the Response to Hypoxia: An Overview
title_full The Role of Sumoylation in the Response to Hypoxia: An Overview
title_fullStr The Role of Sumoylation in the Response to Hypoxia: An Overview
title_full_unstemmed The Role of Sumoylation in the Response to Hypoxia: An Overview
title_short The Role of Sumoylation in the Response to Hypoxia: An Overview
title_sort role of sumoylation in the response to hypoxia: an overview
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7693722/
https://www.ncbi.nlm.nih.gov/pubmed/33114748
http://dx.doi.org/10.3390/cells9112359
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