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Febuxostat, a Xanthine Oxidase Inhibitor, Decreased Macrophage Matrix Metalloproteinase Expression in Hypoxia

Macrophages in the atheroma region produce matrix metalloproteinases (MMPs) and decrease plaque stability. Tissue oxygen tension decreases in the arterial wall of the atherosclerotic region. Hypoxia inducible factor (HIF)-1α plays a critical role in the transcriptional activation of hypoxia inducibl...

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Detalles Bibliográficos
Autores principales:	Wei, Shuoyu, Isagawa, Takayuki, Eguchi, Masamichi, Sato, Daisuke, Tsukano, Hiroto, Miyata, Keishi, Oike, Yuichi, Takeda, Norihiko, Ikeda, Satoshi, Kawano, Hiroaki, Maemura, Koji
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7693746/ https://www.ncbi.nlm.nih.gov/pubmed/33153000 http://dx.doi.org/10.3390/biomedicines8110470

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