A Mutated PB1 Residue 319 Synergizes with the PB2 N265S Mutation of the Live Attenuated Influenza Vaccine to Convey Temperature Sensitivity

Current influenza vaccines have modest efficacy. This is especially true for current live attenuated influenza vaccines (LAIV), which have been inferior to the inactivated versions in recent years. Therefore, a new generation of live vaccines may be needed. We previously showed that a mutation at PB...

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Detalles Bibliográficos
Autores principales: Cox, Andrew, Schmierer, Jordana, D’Angelo, Josephine, Smith, Andrew, Levenson, Dustyn, Treanor, John, Kim, Baek, Dewhurst, Stephen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7693792/
https://www.ncbi.nlm.nih.gov/pubmed/33142846
http://dx.doi.org/10.3390/v12111246

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