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Effectiveness of Chemical Compounds Used against African Swine Fever Virus in Commercial Available Disinfectants
African swine fever (ASF) causes huge economic losses and is one of most dangerous diseases of pigs. The disease is known for almost 100 years, an effective vaccine or treatment is still unavailable, only proper biosecurity measures, including disinfection, are being applied, in order to prevent dis...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7693804/ https://www.ncbi.nlm.nih.gov/pubmed/33114391 http://dx.doi.org/10.3390/pathogens9110878 |
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author | Juszkiewicz, Małgorzata Walczak, Marek Mazur-Panasiuk, Natalia Woźniakowski, Grzegorz |
author_facet | Juszkiewicz, Małgorzata Walczak, Marek Mazur-Panasiuk, Natalia Woźniakowski, Grzegorz |
author_sort | Juszkiewicz, Małgorzata |
collection | PubMed |
description | African swine fever (ASF) causes huge economic losses and is one of most dangerous diseases of pigs. The disease is known for almost 100 years, an effective vaccine or treatment is still unavailable, only proper biosecurity measures, including disinfection, are being applied, in order to prevent disease outbreaks. Eight active substances, i.e., formaldehyde, sodium hypochlorite, caustic soda, glutaraldehyde, phenol, benzalkonium chloride, potassium peroxymonosulfate and acetic acid, were tested, in order to confirm their effectiveness against African swine fever virus (ASFV). This specific selection was done based on the World Organisation for Animal Health (OIE)’s recommendation and previous disinfectant studies on surfaces. The result of our study shows that most of them inactivate the virus, in recommended concentrations. In order to reduce the cytotoxicity of the four substances, Microspin S-400 HR columns were applied, therefore making it possible to demonstrate four logarithms virus titer reduction. Sodium hypochlorite, glutaraldehyde, caustic soda and potassium peroxymonosulfate showed the best ASFV inactivation rates, achieving titer reductions over 5 logs. Despite microfiltration, the virucidal activity of formaldehyde was not assessable, due to its high cytotoxicity. Our results showed that cleaning is particularly important, because removal of the soiling provides improved effectiveness of the tested chemical compounds. |
format | Online Article Text |
id | pubmed-7693804 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-76938042020-11-28 Effectiveness of Chemical Compounds Used against African Swine Fever Virus in Commercial Available Disinfectants Juszkiewicz, Małgorzata Walczak, Marek Mazur-Panasiuk, Natalia Woźniakowski, Grzegorz Pathogens Article African swine fever (ASF) causes huge economic losses and is one of most dangerous diseases of pigs. The disease is known for almost 100 years, an effective vaccine or treatment is still unavailable, only proper biosecurity measures, including disinfection, are being applied, in order to prevent disease outbreaks. Eight active substances, i.e., formaldehyde, sodium hypochlorite, caustic soda, glutaraldehyde, phenol, benzalkonium chloride, potassium peroxymonosulfate and acetic acid, were tested, in order to confirm their effectiveness against African swine fever virus (ASFV). This specific selection was done based on the World Organisation for Animal Health (OIE)’s recommendation and previous disinfectant studies on surfaces. The result of our study shows that most of them inactivate the virus, in recommended concentrations. In order to reduce the cytotoxicity of the four substances, Microspin S-400 HR columns were applied, therefore making it possible to demonstrate four logarithms virus titer reduction. Sodium hypochlorite, glutaraldehyde, caustic soda and potassium peroxymonosulfate showed the best ASFV inactivation rates, achieving titer reductions over 5 logs. Despite microfiltration, the virucidal activity of formaldehyde was not assessable, due to its high cytotoxicity. Our results showed that cleaning is particularly important, because removal of the soiling provides improved effectiveness of the tested chemical compounds. MDPI 2020-10-24 /pmc/articles/PMC7693804/ /pubmed/33114391 http://dx.doi.org/10.3390/pathogens9110878 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Juszkiewicz, Małgorzata Walczak, Marek Mazur-Panasiuk, Natalia Woźniakowski, Grzegorz Effectiveness of Chemical Compounds Used against African Swine Fever Virus in Commercial Available Disinfectants |
title | Effectiveness of Chemical Compounds Used against African Swine Fever Virus in Commercial Available Disinfectants |
title_full | Effectiveness of Chemical Compounds Used against African Swine Fever Virus in Commercial Available Disinfectants |
title_fullStr | Effectiveness of Chemical Compounds Used against African Swine Fever Virus in Commercial Available Disinfectants |
title_full_unstemmed | Effectiveness of Chemical Compounds Used against African Swine Fever Virus in Commercial Available Disinfectants |
title_short | Effectiveness of Chemical Compounds Used against African Swine Fever Virus in Commercial Available Disinfectants |
title_sort | effectiveness of chemical compounds used against african swine fever virus in commercial available disinfectants |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7693804/ https://www.ncbi.nlm.nih.gov/pubmed/33114391 http://dx.doi.org/10.3390/pathogens9110878 |
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