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Dissecting the Genetic Regulation of Yeast Growth Plasticity in Response to Environmental Changes

Variable individual responses to environmental changes, such as phenotype plasticity, are heritable, with some genotypes being robust and others plastic. This variation for plasticity contributes to variance in complex traits as genotype-by-environment interactions (G × E). However, the genetic basi...

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Autores principales: Zan, Yanjun, Carlborg, Örjan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7693874/
https://www.ncbi.nlm.nih.gov/pubmed/33137976
http://dx.doi.org/10.3390/genes11111279
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author Zan, Yanjun
Carlborg, Örjan
author_facet Zan, Yanjun
Carlborg, Örjan
author_sort Zan, Yanjun
collection PubMed
description Variable individual responses to environmental changes, such as phenotype plasticity, are heritable, with some genotypes being robust and others plastic. This variation for plasticity contributes to variance in complex traits as genotype-by-environment interactions (G × E). However, the genetic basis of this variability in responses to the same external stimuli is still largely unknown. In an earlier study of a large haploid segregant yeast population, genotype-by-genotype-by-environment interactions were found to make important contributions to the release of genetic variation in growth responses to alterations of the growth medium. Here, we explore the genetic basis for heritable variation of different measures of phenotype plasticity in the same dataset. We found that the central loci in the environmentally dependent epistatic networks were associated with overall measures of plasticity, while the specific measures of plasticity identified a more diverse set of loci. Based on this, a rapid one-dimensional genome-wide association (GWA) approach to overall plasticity is proposed as a strategy to efficiently identify key epistatic loci contributing to the phenotype plasticity. The study thus provided both analytical strategies and a deeper understanding of the complex genetic regulation of phenotype plasticity in yeast growth.
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spelling pubmed-76938742020-11-28 Dissecting the Genetic Regulation of Yeast Growth Plasticity in Response to Environmental Changes Zan, Yanjun Carlborg, Örjan Genes (Basel) Article Variable individual responses to environmental changes, such as phenotype plasticity, are heritable, with some genotypes being robust and others plastic. This variation for plasticity contributes to variance in complex traits as genotype-by-environment interactions (G × E). However, the genetic basis of this variability in responses to the same external stimuli is still largely unknown. In an earlier study of a large haploid segregant yeast population, genotype-by-genotype-by-environment interactions were found to make important contributions to the release of genetic variation in growth responses to alterations of the growth medium. Here, we explore the genetic basis for heritable variation of different measures of phenotype plasticity in the same dataset. We found that the central loci in the environmentally dependent epistatic networks were associated with overall measures of plasticity, while the specific measures of plasticity identified a more diverse set of loci. Based on this, a rapid one-dimensional genome-wide association (GWA) approach to overall plasticity is proposed as a strategy to efficiently identify key epistatic loci contributing to the phenotype plasticity. The study thus provided both analytical strategies and a deeper understanding of the complex genetic regulation of phenotype plasticity in yeast growth. MDPI 2020-10-29 /pmc/articles/PMC7693874/ /pubmed/33137976 http://dx.doi.org/10.3390/genes11111279 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zan, Yanjun
Carlborg, Örjan
Dissecting the Genetic Regulation of Yeast Growth Plasticity in Response to Environmental Changes
title Dissecting the Genetic Regulation of Yeast Growth Plasticity in Response to Environmental Changes
title_full Dissecting the Genetic Regulation of Yeast Growth Plasticity in Response to Environmental Changes
title_fullStr Dissecting the Genetic Regulation of Yeast Growth Plasticity in Response to Environmental Changes
title_full_unstemmed Dissecting the Genetic Regulation of Yeast Growth Plasticity in Response to Environmental Changes
title_short Dissecting the Genetic Regulation of Yeast Growth Plasticity in Response to Environmental Changes
title_sort dissecting the genetic regulation of yeast growth plasticity in response to environmental changes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7693874/
https://www.ncbi.nlm.nih.gov/pubmed/33137976
http://dx.doi.org/10.3390/genes11111279
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