Lipopeptide Epimers and a Phthalide Glycerol Ether with AChE Inhibitory Activities from the Marine-Derived Fungus Cochliobolus Lunatus SCSIO41401

A pair of novel lipopeptide epimers, sinulariapeptides A (1) and B (2), and a new phthalide glycerol ether (3) were isolated from the marine algal-associated fungus Cochliobolus lunatus SCSIO41401, together with three known chromanone derivates (4–6). The structures of the new compounds, including t...

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Detalles Bibliográficos
Autores principales: Dai, Yu, Li, Kunlong, She, Jianglian, Zeng, Yanbo, Wang, Hao, Liao, Shengrong, Lin, Xiuping, Yang, Bin, Wang, Junfeng, Tao, Huaming, Dai, Haofu, Zhou, Xuefeng, Liu, Yonghong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7693918/
https://www.ncbi.nlm.nih.gov/pubmed/33143384
http://dx.doi.org/10.3390/md18110547
Descripción
Sumario:A pair of novel lipopeptide epimers, sinulariapeptides A (1) and B (2), and a new phthalide glycerol ether (3) were isolated from the marine algal-associated fungus Cochliobolus lunatus SCSIO41401, together with three known chromanone derivates (4–6). The structures of the new compounds, including the absolute configurations, were determined by comprehensive spectroscopic methods, experimental and calculated electronic circular dichroism (ECD), and Mo(2) (OAc)(4)-induced ECD methods. The new compounds 1–3 showed moderate inhibitory activity against acetylcholinesterase (AChE), with IC(50) values of 1.3–2.5 μM, and an in silico molecular docking study was also performed.

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