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Post-Translational S-Nitrosylation of Proteins in Regulating Cardiac Oxidative Stress

Like other post-translational modifications (PTMs) of proteins, S-nitrosylation has been considered a key regulatory mechanism of multiple cellular functions in many physiological and disease conditions. Emerging evidence has demonstrated that S-nitrosylation plays a crucial role in regulating redox...

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Detalles Bibliográficos
Autores principales: Shi, Xiaomeng, Qiu, Hongyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7693965/
https://www.ncbi.nlm.nih.gov/pubmed/33126514
http://dx.doi.org/10.3390/antiox9111051
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author Shi, Xiaomeng
Qiu, Hongyu
author_facet Shi, Xiaomeng
Qiu, Hongyu
author_sort Shi, Xiaomeng
collection PubMed
description Like other post-translational modifications (PTMs) of proteins, S-nitrosylation has been considered a key regulatory mechanism of multiple cellular functions in many physiological and disease conditions. Emerging evidence has demonstrated that S-nitrosylation plays a crucial role in regulating redox homeostasis in the stressed heart, leading to discoveries in the mechanisms underlying the pathogenesis of heart diseases and cardiac protection. In this review, we summarize recent studies in understanding the molecular and biological basis of S-nitrosylation, including the formation, spatiotemporal specificity, homeostatic regulation, and association with cellular redox status. We also outline the currently available methods that have been applied to detect S-nitrosylation. Additionally, we synopsize the up-to-date studies of S-nitrosylation in various cardiac diseases in humans and animal models, and we discuss its therapeutic potential in cardiac protection. These pieces of information would bring new insights into understanding the role of S-nitrosylation in cardiac pathogenesis and provide novel avenues for developing novel therapeutic strategies for heart diseases.
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spelling pubmed-76939652020-11-28 Post-Translational S-Nitrosylation of Proteins in Regulating Cardiac Oxidative Stress Shi, Xiaomeng Qiu, Hongyu Antioxidants (Basel) Review Like other post-translational modifications (PTMs) of proteins, S-nitrosylation has been considered a key regulatory mechanism of multiple cellular functions in many physiological and disease conditions. Emerging evidence has demonstrated that S-nitrosylation plays a crucial role in regulating redox homeostasis in the stressed heart, leading to discoveries in the mechanisms underlying the pathogenesis of heart diseases and cardiac protection. In this review, we summarize recent studies in understanding the molecular and biological basis of S-nitrosylation, including the formation, spatiotemporal specificity, homeostatic regulation, and association with cellular redox status. We also outline the currently available methods that have been applied to detect S-nitrosylation. Additionally, we synopsize the up-to-date studies of S-nitrosylation in various cardiac diseases in humans and animal models, and we discuss its therapeutic potential in cardiac protection. These pieces of information would bring new insights into understanding the role of S-nitrosylation in cardiac pathogenesis and provide novel avenues for developing novel therapeutic strategies for heart diseases. MDPI 2020-10-28 /pmc/articles/PMC7693965/ /pubmed/33126514 http://dx.doi.org/10.3390/antiox9111051 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Shi, Xiaomeng
Qiu, Hongyu
Post-Translational S-Nitrosylation of Proteins in Regulating Cardiac Oxidative Stress
title Post-Translational S-Nitrosylation of Proteins in Regulating Cardiac Oxidative Stress
title_full Post-Translational S-Nitrosylation of Proteins in Regulating Cardiac Oxidative Stress
title_fullStr Post-Translational S-Nitrosylation of Proteins in Regulating Cardiac Oxidative Stress
title_full_unstemmed Post-Translational S-Nitrosylation of Proteins in Regulating Cardiac Oxidative Stress
title_short Post-Translational S-Nitrosylation of Proteins in Regulating Cardiac Oxidative Stress
title_sort post-translational s-nitrosylation of proteins in regulating cardiac oxidative stress
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7693965/
https://www.ncbi.nlm.nih.gov/pubmed/33126514
http://dx.doi.org/10.3390/antiox9111051
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