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Outcomes of Pediatric Liver Transplantation in Korea Using Two National Registries
Background: This retrospective study aimed to evaluate overall survival and the risk factors for mortality among Korean pediatric liver transplantation (LT) patients using data from two national registries: the Korean Network Organ Sharing (KONOS) of the Korea Centers for Disease Control and Prevent...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7694033/ https://www.ncbi.nlm.nih.gov/pubmed/33114650 http://dx.doi.org/10.3390/jcm9113435 |
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author | Hong, Suk Kyun Yi, Nam-Joon Yoon, Kyung Chul Kim, Myoung Soo Lee, Jae Geun Lee, Sanghoon Kang, Koo Jeong Hwang, Shin Ryu, Je Ho Hong, Kwangpyo Han, Eui Soo Lee, Jeong-Moo Lee, Kwang-Woong Suh, Kyung-Suk |
author_facet | Hong, Suk Kyun Yi, Nam-Joon Yoon, Kyung Chul Kim, Myoung Soo Lee, Jae Geun Lee, Sanghoon Kang, Koo Jeong Hwang, Shin Ryu, Je Ho Hong, Kwangpyo Han, Eui Soo Lee, Jeong-Moo Lee, Kwang-Woong Suh, Kyung-Suk |
author_sort | Hong, Suk Kyun |
collection | PubMed |
description | Background: This retrospective study aimed to evaluate overall survival and the risk factors for mortality among Korean pediatric liver transplantation (LT) patients using data from two national registries: the Korean Network Organ Sharing (KONOS) of the Korea Centers for Disease Control and Prevention and the Korean Organ Transplantation Registry (KOTRY). Methods: Prospectively collected data of 755 pediatric patients who underwent primary LT (KONOS, February 2000 to December 2015; KOTRY, May 2014 to December 2017) were retrospectively reviewed. Results: The 1-, 5-, 10-, and 15-year survival rates were 90.6%, 86.7%, 85.8%, and 85.5%, respectively, in KONOS, and the 1-month, 3-month, 1-year, and 2-year survival rates were 92.1%, 89.4%, 89.4%, and 87.2%, respectively, in KOTRY. There was no significant difference in survival between the two registries. Multivariate analysis identified that body weight ≥6 kg (p <0.001), biliary atresia as underlying liver disease (p = 0.001), and high-volume center (p < 0.001) were associated with better survival according to the KONOS database, while hepatic artery complication (p < 0.001) was associated with poorer overall survival rates according to the KOTRY database. Conclusion: Long-term pediatric patient survival after LT was satisfactory in this Korean national registry analysis. However, children with risk factors for poor outcomes should be carefully managed after LT. |
format | Online Article Text |
id | pubmed-7694033 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-76940332020-11-28 Outcomes of Pediatric Liver Transplantation in Korea Using Two National Registries Hong, Suk Kyun Yi, Nam-Joon Yoon, Kyung Chul Kim, Myoung Soo Lee, Jae Geun Lee, Sanghoon Kang, Koo Jeong Hwang, Shin Ryu, Je Ho Hong, Kwangpyo Han, Eui Soo Lee, Jeong-Moo Lee, Kwang-Woong Suh, Kyung-Suk J Clin Med Article Background: This retrospective study aimed to evaluate overall survival and the risk factors for mortality among Korean pediatric liver transplantation (LT) patients using data from two national registries: the Korean Network Organ Sharing (KONOS) of the Korea Centers for Disease Control and Prevention and the Korean Organ Transplantation Registry (KOTRY). Methods: Prospectively collected data of 755 pediatric patients who underwent primary LT (KONOS, February 2000 to December 2015; KOTRY, May 2014 to December 2017) were retrospectively reviewed. Results: The 1-, 5-, 10-, and 15-year survival rates were 90.6%, 86.7%, 85.8%, and 85.5%, respectively, in KONOS, and the 1-month, 3-month, 1-year, and 2-year survival rates were 92.1%, 89.4%, 89.4%, and 87.2%, respectively, in KOTRY. There was no significant difference in survival between the two registries. Multivariate analysis identified that body weight ≥6 kg (p <0.001), biliary atresia as underlying liver disease (p = 0.001), and high-volume center (p < 0.001) were associated with better survival according to the KONOS database, while hepatic artery complication (p < 0.001) was associated with poorer overall survival rates according to the KOTRY database. Conclusion: Long-term pediatric patient survival after LT was satisfactory in this Korean national registry analysis. However, children with risk factors for poor outcomes should be carefully managed after LT. MDPI 2020-10-26 /pmc/articles/PMC7694033/ /pubmed/33114650 http://dx.doi.org/10.3390/jcm9113435 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Hong, Suk Kyun Yi, Nam-Joon Yoon, Kyung Chul Kim, Myoung Soo Lee, Jae Geun Lee, Sanghoon Kang, Koo Jeong Hwang, Shin Ryu, Je Ho Hong, Kwangpyo Han, Eui Soo Lee, Jeong-Moo Lee, Kwang-Woong Suh, Kyung-Suk Outcomes of Pediatric Liver Transplantation in Korea Using Two National Registries |
title | Outcomes of Pediatric Liver Transplantation in Korea Using Two National Registries |
title_full | Outcomes of Pediatric Liver Transplantation in Korea Using Two National Registries |
title_fullStr | Outcomes of Pediatric Liver Transplantation in Korea Using Two National Registries |
title_full_unstemmed | Outcomes of Pediatric Liver Transplantation in Korea Using Two National Registries |
title_short | Outcomes of Pediatric Liver Transplantation in Korea Using Two National Registries |
title_sort | outcomes of pediatric liver transplantation in korea using two national registries |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7694033/ https://www.ncbi.nlm.nih.gov/pubmed/33114650 http://dx.doi.org/10.3390/jcm9113435 |
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