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Outcomes of Pediatric Liver Transplantation in Korea Using Two National Registries

Background: This retrospective study aimed to evaluate overall survival and the risk factors for mortality among Korean pediatric liver transplantation (LT) patients using data from two national registries: the Korean Network Organ Sharing (KONOS) of the Korea Centers for Disease Control and Prevent...

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Autores principales: Hong, Suk Kyun, Yi, Nam-Joon, Yoon, Kyung Chul, Kim, Myoung Soo, Lee, Jae Geun, Lee, Sanghoon, Kang, Koo Jeong, Hwang, Shin, Ryu, Je Ho, Hong, Kwangpyo, Han, Eui Soo, Lee, Jeong-Moo, Lee, Kwang-Woong, Suh, Kyung-Suk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7694033/
https://www.ncbi.nlm.nih.gov/pubmed/33114650
http://dx.doi.org/10.3390/jcm9113435
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author Hong, Suk Kyun
Yi, Nam-Joon
Yoon, Kyung Chul
Kim, Myoung Soo
Lee, Jae Geun
Lee, Sanghoon
Kang, Koo Jeong
Hwang, Shin
Ryu, Je Ho
Hong, Kwangpyo
Han, Eui Soo
Lee, Jeong-Moo
Lee, Kwang-Woong
Suh, Kyung-Suk
author_facet Hong, Suk Kyun
Yi, Nam-Joon
Yoon, Kyung Chul
Kim, Myoung Soo
Lee, Jae Geun
Lee, Sanghoon
Kang, Koo Jeong
Hwang, Shin
Ryu, Je Ho
Hong, Kwangpyo
Han, Eui Soo
Lee, Jeong-Moo
Lee, Kwang-Woong
Suh, Kyung-Suk
author_sort Hong, Suk Kyun
collection PubMed
description Background: This retrospective study aimed to evaluate overall survival and the risk factors for mortality among Korean pediatric liver transplantation (LT) patients using data from two national registries: the Korean Network Organ Sharing (KONOS) of the Korea Centers for Disease Control and Prevention and the Korean Organ Transplantation Registry (KOTRY). Methods: Prospectively collected data of 755 pediatric patients who underwent primary LT (KONOS, February 2000 to December 2015; KOTRY, May 2014 to December 2017) were retrospectively reviewed. Results: The 1-, 5-, 10-, and 15-year survival rates were 90.6%, 86.7%, 85.8%, and 85.5%, respectively, in KONOS, and the 1-month, 3-month, 1-year, and 2-year survival rates were 92.1%, 89.4%, 89.4%, and 87.2%, respectively, in KOTRY. There was no significant difference in survival between the two registries. Multivariate analysis identified that body weight ≥6 kg (p <0.001), biliary atresia as underlying liver disease (p = 0.001), and high-volume center (p < 0.001) were associated with better survival according to the KONOS database, while hepatic artery complication (p < 0.001) was associated with poorer overall survival rates according to the KOTRY database. Conclusion: Long-term pediatric patient survival after LT was satisfactory in this Korean national registry analysis. However, children with risk factors for poor outcomes should be carefully managed after LT.
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spelling pubmed-76940332020-11-28 Outcomes of Pediatric Liver Transplantation in Korea Using Two National Registries Hong, Suk Kyun Yi, Nam-Joon Yoon, Kyung Chul Kim, Myoung Soo Lee, Jae Geun Lee, Sanghoon Kang, Koo Jeong Hwang, Shin Ryu, Je Ho Hong, Kwangpyo Han, Eui Soo Lee, Jeong-Moo Lee, Kwang-Woong Suh, Kyung-Suk J Clin Med Article Background: This retrospective study aimed to evaluate overall survival and the risk factors for mortality among Korean pediatric liver transplantation (LT) patients using data from two national registries: the Korean Network Organ Sharing (KONOS) of the Korea Centers for Disease Control and Prevention and the Korean Organ Transplantation Registry (KOTRY). Methods: Prospectively collected data of 755 pediatric patients who underwent primary LT (KONOS, February 2000 to December 2015; KOTRY, May 2014 to December 2017) were retrospectively reviewed. Results: The 1-, 5-, 10-, and 15-year survival rates were 90.6%, 86.7%, 85.8%, and 85.5%, respectively, in KONOS, and the 1-month, 3-month, 1-year, and 2-year survival rates were 92.1%, 89.4%, 89.4%, and 87.2%, respectively, in KOTRY. There was no significant difference in survival between the two registries. Multivariate analysis identified that body weight ≥6 kg (p <0.001), biliary atresia as underlying liver disease (p = 0.001), and high-volume center (p < 0.001) were associated with better survival according to the KONOS database, while hepatic artery complication (p < 0.001) was associated with poorer overall survival rates according to the KOTRY database. Conclusion: Long-term pediatric patient survival after LT was satisfactory in this Korean national registry analysis. However, children with risk factors for poor outcomes should be carefully managed after LT. MDPI 2020-10-26 /pmc/articles/PMC7694033/ /pubmed/33114650 http://dx.doi.org/10.3390/jcm9113435 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hong, Suk Kyun
Yi, Nam-Joon
Yoon, Kyung Chul
Kim, Myoung Soo
Lee, Jae Geun
Lee, Sanghoon
Kang, Koo Jeong
Hwang, Shin
Ryu, Je Ho
Hong, Kwangpyo
Han, Eui Soo
Lee, Jeong-Moo
Lee, Kwang-Woong
Suh, Kyung-Suk
Outcomes of Pediatric Liver Transplantation in Korea Using Two National Registries
title Outcomes of Pediatric Liver Transplantation in Korea Using Two National Registries
title_full Outcomes of Pediatric Liver Transplantation in Korea Using Two National Registries
title_fullStr Outcomes of Pediatric Liver Transplantation in Korea Using Two National Registries
title_full_unstemmed Outcomes of Pediatric Liver Transplantation in Korea Using Two National Registries
title_short Outcomes of Pediatric Liver Transplantation in Korea Using Two National Registries
title_sort outcomes of pediatric liver transplantation in korea using two national registries
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7694033/
https://www.ncbi.nlm.nih.gov/pubmed/33114650
http://dx.doi.org/10.3390/jcm9113435
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