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Neurodevelopmental Disorders: Effect of High-Fat Diet on Synaptic Plasticity and Mitochondrial Functions

Neurodevelopmental disorders (NDDs) include diverse neuropathologies characterized by abnormal brain development leading to impaired cognition, communication and social skills. A common feature of NDDs is defective synaptic plasticity, but the underlying molecular mechanisms are only partially known...

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Autores principales: Penna, Eduardo, Pizzella, Amelia, Cimmino, Fabiano, Trinchese, Giovanna, Cavaliere, Gina, Catapano, Angela, Allocca, Ivana, Chun, Jong Tai, Campanozzi, Angelo, Messina, Giovanni, Precenzano, Francesco, Lanzara, Valentina, Messina, Antonietta, Monda, Vincenzo, Monda, Marcellino, Perrone-Capano, Carla, Mollica, Maria Pina, Crispino, Marianna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7694125/
https://www.ncbi.nlm.nih.gov/pubmed/33142719
http://dx.doi.org/10.3390/brainsci10110805
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author Penna, Eduardo
Pizzella, Amelia
Cimmino, Fabiano
Trinchese, Giovanna
Cavaliere, Gina
Catapano, Angela
Allocca, Ivana
Chun, Jong Tai
Campanozzi, Angelo
Messina, Giovanni
Precenzano, Francesco
Lanzara, Valentina
Messina, Antonietta
Monda, Vincenzo
Monda, Marcellino
Perrone-Capano, Carla
Mollica, Maria Pina
Crispino, Marianna
author_facet Penna, Eduardo
Pizzella, Amelia
Cimmino, Fabiano
Trinchese, Giovanna
Cavaliere, Gina
Catapano, Angela
Allocca, Ivana
Chun, Jong Tai
Campanozzi, Angelo
Messina, Giovanni
Precenzano, Francesco
Lanzara, Valentina
Messina, Antonietta
Monda, Vincenzo
Monda, Marcellino
Perrone-Capano, Carla
Mollica, Maria Pina
Crispino, Marianna
author_sort Penna, Eduardo
collection PubMed
description Neurodevelopmental disorders (NDDs) include diverse neuropathologies characterized by abnormal brain development leading to impaired cognition, communication and social skills. A common feature of NDDs is defective synaptic plasticity, but the underlying molecular mechanisms are only partially known. Several studies have indicated that people’s lifestyles such as diet pattern and physical exercise have significant influence on synaptic plasticity of the brain. Indeed, it has been reported that a high-fat diet (HFD, with 30–50% fat content), which leads to systemic low-grade inflammation, has also a detrimental effect on synaptic efficiency. Interestingly, metabolic alterations associated with obesity in pregnant woman may represent a risk factor for NDDs in the offspring. In this review, we have discussed the potential molecular mechanisms linking the HFD-induced metabolic dysfunctions to altered synaptic plasticity underlying NDDs, with a special emphasis on the roles played by synaptic protein synthesis and mitochondrial functions.
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spelling pubmed-76941252020-11-28 Neurodevelopmental Disorders: Effect of High-Fat Diet on Synaptic Plasticity and Mitochondrial Functions Penna, Eduardo Pizzella, Amelia Cimmino, Fabiano Trinchese, Giovanna Cavaliere, Gina Catapano, Angela Allocca, Ivana Chun, Jong Tai Campanozzi, Angelo Messina, Giovanni Precenzano, Francesco Lanzara, Valentina Messina, Antonietta Monda, Vincenzo Monda, Marcellino Perrone-Capano, Carla Mollica, Maria Pina Crispino, Marianna Brain Sci Review Neurodevelopmental disorders (NDDs) include diverse neuropathologies characterized by abnormal brain development leading to impaired cognition, communication and social skills. A common feature of NDDs is defective synaptic plasticity, but the underlying molecular mechanisms are only partially known. Several studies have indicated that people’s lifestyles such as diet pattern and physical exercise have significant influence on synaptic plasticity of the brain. Indeed, it has been reported that a high-fat diet (HFD, with 30–50% fat content), which leads to systemic low-grade inflammation, has also a detrimental effect on synaptic efficiency. Interestingly, metabolic alterations associated with obesity in pregnant woman may represent a risk factor for NDDs in the offspring. In this review, we have discussed the potential molecular mechanisms linking the HFD-induced metabolic dysfunctions to altered synaptic plasticity underlying NDDs, with a special emphasis on the roles played by synaptic protein synthesis and mitochondrial functions. MDPI 2020-10-31 /pmc/articles/PMC7694125/ /pubmed/33142719 http://dx.doi.org/10.3390/brainsci10110805 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Penna, Eduardo
Pizzella, Amelia
Cimmino, Fabiano
Trinchese, Giovanna
Cavaliere, Gina
Catapano, Angela
Allocca, Ivana
Chun, Jong Tai
Campanozzi, Angelo
Messina, Giovanni
Precenzano, Francesco
Lanzara, Valentina
Messina, Antonietta
Monda, Vincenzo
Monda, Marcellino
Perrone-Capano, Carla
Mollica, Maria Pina
Crispino, Marianna
Neurodevelopmental Disorders: Effect of High-Fat Diet on Synaptic Plasticity and Mitochondrial Functions
title Neurodevelopmental Disorders: Effect of High-Fat Diet on Synaptic Plasticity and Mitochondrial Functions
title_full Neurodevelopmental Disorders: Effect of High-Fat Diet on Synaptic Plasticity and Mitochondrial Functions
title_fullStr Neurodevelopmental Disorders: Effect of High-Fat Diet on Synaptic Plasticity and Mitochondrial Functions
title_full_unstemmed Neurodevelopmental Disorders: Effect of High-Fat Diet on Synaptic Plasticity and Mitochondrial Functions
title_short Neurodevelopmental Disorders: Effect of High-Fat Diet on Synaptic Plasticity and Mitochondrial Functions
title_sort neurodevelopmental disorders: effect of high-fat diet on synaptic plasticity and mitochondrial functions
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7694125/
https://www.ncbi.nlm.nih.gov/pubmed/33142719
http://dx.doi.org/10.3390/brainsci10110805
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