Cargando…

Electrospinning/Electrospray of Ferrocene Containing Copolymers to Fabricate ROS-Responsive Particles and Fibers

We demonstrate an electrospray/electrospinning process to fabricate stimuli-responsive nanofibers or particles that can be utilized as stimuli-responsive drug-loaded materials. A series of random copolymers consisting of hydrophobic ferrocene monomers and hydrophilic carboxyl groups, namely poly(fer...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Hoik, Woo, Jiseob, Son, Dongwan, Kim, Myungwoong, Choi, Won Il, Sung, Daekyung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7694134/
https://www.ncbi.nlm.nih.gov/pubmed/33138105
http://dx.doi.org/10.3390/polym12112520
_version_ 1783614906927415296
author Lee, Hoik
Woo, Jiseob
Son, Dongwan
Kim, Myungwoong
Choi, Won Il
Sung, Daekyung
author_facet Lee, Hoik
Woo, Jiseob
Son, Dongwan
Kim, Myungwoong
Choi, Won Il
Sung, Daekyung
author_sort Lee, Hoik
collection PubMed
description We demonstrate an electrospray/electrospinning process to fabricate stimuli-responsive nanofibers or particles that can be utilized as stimuli-responsive drug-loaded materials. A series of random copolymers consisting of hydrophobic ferrocene monomers and hydrophilic carboxyl groups, namely poly(ferrocenylmethyl methacrylate-r-methacrylic acid) [poly(FMMA-r-MA)] with varied composition, was synthesized with free radical copolymerization. The morphologies of the resulting objects created by electrospray/electrospinning of the poly(FMMA-r-MA) solutions were effectively varied from particulate to fibrous structures by control of the composition, suggesting that the morphology of electrosprayed/electrospun copolymer objects was governed by its composition and hence, interaction with the solvent, highlighting the significance of the balance of hydrophilicity/hydrophobicity of the copolymer chain to the assembled structure. Resulting particles and nanofibers exhibited largely preserved responsiveness to reactive oxygen species (ROS) during the deposition process, opening up the potential to fabricate ROS-sensitive material with various desirable structures toward different applications.
format Online
Article
Text
id pubmed-7694134
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-76941342020-11-28 Electrospinning/Electrospray of Ferrocene Containing Copolymers to Fabricate ROS-Responsive Particles and Fibers Lee, Hoik Woo, Jiseob Son, Dongwan Kim, Myungwoong Choi, Won Il Sung, Daekyung Polymers (Basel) Article We demonstrate an electrospray/electrospinning process to fabricate stimuli-responsive nanofibers or particles that can be utilized as stimuli-responsive drug-loaded materials. A series of random copolymers consisting of hydrophobic ferrocene monomers and hydrophilic carboxyl groups, namely poly(ferrocenylmethyl methacrylate-r-methacrylic acid) [poly(FMMA-r-MA)] with varied composition, was synthesized with free radical copolymerization. The morphologies of the resulting objects created by electrospray/electrospinning of the poly(FMMA-r-MA) solutions were effectively varied from particulate to fibrous structures by control of the composition, suggesting that the morphology of electrosprayed/electrospun copolymer objects was governed by its composition and hence, interaction with the solvent, highlighting the significance of the balance of hydrophilicity/hydrophobicity of the copolymer chain to the assembled structure. Resulting particles and nanofibers exhibited largely preserved responsiveness to reactive oxygen species (ROS) during the deposition process, opening up the potential to fabricate ROS-sensitive material with various desirable structures toward different applications. MDPI 2020-10-29 /pmc/articles/PMC7694134/ /pubmed/33138105 http://dx.doi.org/10.3390/polym12112520 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lee, Hoik
Woo, Jiseob
Son, Dongwan
Kim, Myungwoong
Choi, Won Il
Sung, Daekyung
Electrospinning/Electrospray of Ferrocene Containing Copolymers to Fabricate ROS-Responsive Particles and Fibers
title Electrospinning/Electrospray of Ferrocene Containing Copolymers to Fabricate ROS-Responsive Particles and Fibers
title_full Electrospinning/Electrospray of Ferrocene Containing Copolymers to Fabricate ROS-Responsive Particles and Fibers
title_fullStr Electrospinning/Electrospray of Ferrocene Containing Copolymers to Fabricate ROS-Responsive Particles and Fibers
title_full_unstemmed Electrospinning/Electrospray of Ferrocene Containing Copolymers to Fabricate ROS-Responsive Particles and Fibers
title_short Electrospinning/Electrospray of Ferrocene Containing Copolymers to Fabricate ROS-Responsive Particles and Fibers
title_sort electrospinning/electrospray of ferrocene containing copolymers to fabricate ros-responsive particles and fibers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7694134/
https://www.ncbi.nlm.nih.gov/pubmed/33138105
http://dx.doi.org/10.3390/polym12112520
work_keys_str_mv AT leehoik electrospinningelectrosprayofferrocenecontainingcopolymerstofabricaterosresponsiveparticlesandfibers
AT woojiseob electrospinningelectrosprayofferrocenecontainingcopolymerstofabricaterosresponsiveparticlesandfibers
AT sondongwan electrospinningelectrosprayofferrocenecontainingcopolymerstofabricaterosresponsiveparticlesandfibers
AT kimmyungwoong electrospinningelectrosprayofferrocenecontainingcopolymerstofabricaterosresponsiveparticlesandfibers
AT choiwonil electrospinningelectrosprayofferrocenecontainingcopolymerstofabricaterosresponsiveparticlesandfibers
AT sungdaekyung electrospinningelectrosprayofferrocenecontainingcopolymerstofabricaterosresponsiveparticlesandfibers