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Electrospinning/Electrospray of Ferrocene Containing Copolymers to Fabricate ROS-Responsive Particles and Fibers
We demonstrate an electrospray/electrospinning process to fabricate stimuli-responsive nanofibers or particles that can be utilized as stimuli-responsive drug-loaded materials. A series of random copolymers consisting of hydrophobic ferrocene monomers and hydrophilic carboxyl groups, namely poly(fer...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7694134/ https://www.ncbi.nlm.nih.gov/pubmed/33138105 http://dx.doi.org/10.3390/polym12112520 |
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author | Lee, Hoik Woo, Jiseob Son, Dongwan Kim, Myungwoong Choi, Won Il Sung, Daekyung |
author_facet | Lee, Hoik Woo, Jiseob Son, Dongwan Kim, Myungwoong Choi, Won Il Sung, Daekyung |
author_sort | Lee, Hoik |
collection | PubMed |
description | We demonstrate an electrospray/electrospinning process to fabricate stimuli-responsive nanofibers or particles that can be utilized as stimuli-responsive drug-loaded materials. A series of random copolymers consisting of hydrophobic ferrocene monomers and hydrophilic carboxyl groups, namely poly(ferrocenylmethyl methacrylate-r-methacrylic acid) [poly(FMMA-r-MA)] with varied composition, was synthesized with free radical copolymerization. The morphologies of the resulting objects created by electrospray/electrospinning of the poly(FMMA-r-MA) solutions were effectively varied from particulate to fibrous structures by control of the composition, suggesting that the morphology of electrosprayed/electrospun copolymer objects was governed by its composition and hence, interaction with the solvent, highlighting the significance of the balance of hydrophilicity/hydrophobicity of the copolymer chain to the assembled structure. Resulting particles and nanofibers exhibited largely preserved responsiveness to reactive oxygen species (ROS) during the deposition process, opening up the potential to fabricate ROS-sensitive material with various desirable structures toward different applications. |
format | Online Article Text |
id | pubmed-7694134 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-76941342020-11-28 Electrospinning/Electrospray of Ferrocene Containing Copolymers to Fabricate ROS-Responsive Particles and Fibers Lee, Hoik Woo, Jiseob Son, Dongwan Kim, Myungwoong Choi, Won Il Sung, Daekyung Polymers (Basel) Article We demonstrate an electrospray/electrospinning process to fabricate stimuli-responsive nanofibers or particles that can be utilized as stimuli-responsive drug-loaded materials. A series of random copolymers consisting of hydrophobic ferrocene monomers and hydrophilic carboxyl groups, namely poly(ferrocenylmethyl methacrylate-r-methacrylic acid) [poly(FMMA-r-MA)] with varied composition, was synthesized with free radical copolymerization. The morphologies of the resulting objects created by electrospray/electrospinning of the poly(FMMA-r-MA) solutions were effectively varied from particulate to fibrous structures by control of the composition, suggesting that the morphology of electrosprayed/electrospun copolymer objects was governed by its composition and hence, interaction with the solvent, highlighting the significance of the balance of hydrophilicity/hydrophobicity of the copolymer chain to the assembled structure. Resulting particles and nanofibers exhibited largely preserved responsiveness to reactive oxygen species (ROS) during the deposition process, opening up the potential to fabricate ROS-sensitive material with various desirable structures toward different applications. MDPI 2020-10-29 /pmc/articles/PMC7694134/ /pubmed/33138105 http://dx.doi.org/10.3390/polym12112520 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Lee, Hoik Woo, Jiseob Son, Dongwan Kim, Myungwoong Choi, Won Il Sung, Daekyung Electrospinning/Electrospray of Ferrocene Containing Copolymers to Fabricate ROS-Responsive Particles and Fibers |
title | Electrospinning/Electrospray of Ferrocene Containing Copolymers to Fabricate ROS-Responsive Particles and Fibers |
title_full | Electrospinning/Electrospray of Ferrocene Containing Copolymers to Fabricate ROS-Responsive Particles and Fibers |
title_fullStr | Electrospinning/Electrospray of Ferrocene Containing Copolymers to Fabricate ROS-Responsive Particles and Fibers |
title_full_unstemmed | Electrospinning/Electrospray of Ferrocene Containing Copolymers to Fabricate ROS-Responsive Particles and Fibers |
title_short | Electrospinning/Electrospray of Ferrocene Containing Copolymers to Fabricate ROS-Responsive Particles and Fibers |
title_sort | electrospinning/electrospray of ferrocene containing copolymers to fabricate ros-responsive particles and fibers |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7694134/ https://www.ncbi.nlm.nih.gov/pubmed/33138105 http://dx.doi.org/10.3390/polym12112520 |
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