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Polyunsaturated Fatty Acids and Their Metabolites in Hyperemesis Gravidarum

Polyunsaturated fatty acids (PUFAs) have been studied in relation to pregnancy. However, there is limited knowledge on PUFAs and their metabolites in relation to hyperemesis gravidarum (HG), a pregnancy complication associated with nutritional deficiencies and excessive vomiting. In order to survey...

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Autores principales: Lindberg, Richard, Lindqvist, Maria, Trupp, Miles, Vinnars, Marie-Therese, Nording, Malin L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7694173/
https://www.ncbi.nlm.nih.gov/pubmed/33158081
http://dx.doi.org/10.3390/nu12113384
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author Lindberg, Richard
Lindqvist, Maria
Trupp, Miles
Vinnars, Marie-Therese
Nording, Malin L.
author_facet Lindberg, Richard
Lindqvist, Maria
Trupp, Miles
Vinnars, Marie-Therese
Nording, Malin L.
author_sort Lindberg, Richard
collection PubMed
description Polyunsaturated fatty acids (PUFAs) have been studied in relation to pregnancy. However, there is limited knowledge on PUFAs and their metabolites in relation to hyperemesis gravidarum (HG), a pregnancy complication associated with nutritional deficiencies and excessive vomiting. In order to survey the field, a systematic review of the literature was performed, which also included nausea and vomiting of pregnancy (NVP) due to its close relationship with HG. In the very few published studies found, the main subjects of the research concerned free fatty acids (four records), lipid profiles (three records), and bioactive lipids (one article about prostaglandin E(2) and one about endocannabinoids). The authors of these studies concluded that, although no cause-and-effect relationship can be established, HG is linked to increased sympathetic responsiveness, thermogenic activity and metabolic rate. In addition, NVP is linked to a metabolic perturbance (which lasts throughout pregnancy). The low number of retrieved records underlines the need for more research in the area of PUFAs and HG, especially with regard to the underlying mechanism for the detected effects, potentially involving growth differentiation factor 15 (GDF15) since evidence for GDF15 regulation of lipid metabolism and the role for GDF15 and its receptor in nausea and vomiting is emerging.
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spelling pubmed-76941732020-11-28 Polyunsaturated Fatty Acids and Their Metabolites in Hyperemesis Gravidarum Lindberg, Richard Lindqvist, Maria Trupp, Miles Vinnars, Marie-Therese Nording, Malin L. Nutrients Review Polyunsaturated fatty acids (PUFAs) have been studied in relation to pregnancy. However, there is limited knowledge on PUFAs and their metabolites in relation to hyperemesis gravidarum (HG), a pregnancy complication associated with nutritional deficiencies and excessive vomiting. In order to survey the field, a systematic review of the literature was performed, which also included nausea and vomiting of pregnancy (NVP) due to its close relationship with HG. In the very few published studies found, the main subjects of the research concerned free fatty acids (four records), lipid profiles (three records), and bioactive lipids (one article about prostaglandin E(2) and one about endocannabinoids). The authors of these studies concluded that, although no cause-and-effect relationship can be established, HG is linked to increased sympathetic responsiveness, thermogenic activity and metabolic rate. In addition, NVP is linked to a metabolic perturbance (which lasts throughout pregnancy). The low number of retrieved records underlines the need for more research in the area of PUFAs and HG, especially with regard to the underlying mechanism for the detected effects, potentially involving growth differentiation factor 15 (GDF15) since evidence for GDF15 regulation of lipid metabolism and the role for GDF15 and its receptor in nausea and vomiting is emerging. MDPI 2020-11-04 /pmc/articles/PMC7694173/ /pubmed/33158081 http://dx.doi.org/10.3390/nu12113384 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lindberg, Richard
Lindqvist, Maria
Trupp, Miles
Vinnars, Marie-Therese
Nording, Malin L.
Polyunsaturated Fatty Acids and Their Metabolites in Hyperemesis Gravidarum
title Polyunsaturated Fatty Acids and Their Metabolites in Hyperemesis Gravidarum
title_full Polyunsaturated Fatty Acids and Their Metabolites in Hyperemesis Gravidarum
title_fullStr Polyunsaturated Fatty Acids and Their Metabolites in Hyperemesis Gravidarum
title_full_unstemmed Polyunsaturated Fatty Acids and Their Metabolites in Hyperemesis Gravidarum
title_short Polyunsaturated Fatty Acids and Their Metabolites in Hyperemesis Gravidarum
title_sort polyunsaturated fatty acids and their metabolites in hyperemesis gravidarum
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7694173/
https://www.ncbi.nlm.nih.gov/pubmed/33158081
http://dx.doi.org/10.3390/nu12113384
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