Cardiac and Vascular α(1)-Adrenoceptors in Congestive Heart Failure: A Systematic Review

As heart failure (HF) is a devastating health problem worldwide, a better understanding and the development of more effective therapeutic approaches are required. HF is characterized by sympathetic system activation which stimulates α- and β-adrenoceptors (ARs). The exposure of the cardiovascular system to the increased locally released and circulating levels of catecholamines leads to a well-described downregulation and desensitization of β-ARs. However, information on the role of α-AR is limited. We have performed a systematic literature review examining the role of both cardiac and vascular α(1)-ARs in HF using 5 databases for our search. All three α(1)-AR subtypes (α(1A), α(1B) and α(1D)) are expressed in human and animal hearts and blood vessels in a tissue-dependent manner. We summarize the changes observed in HF regarding the density, signaling and responses of α(1)-ARs. Conflicting findings arise from different studies concerning the influence that HF has on α(1)-AR expression and function; in contrast to β-ARs there is no consistent evidence for down-regulation or desensitization of cardiac or vascular α(1)-ARs. Whether α(1)-ARs are a therapeutic target in HF remains a matter of debate.