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All You Need Is Light. Photorepair of UV-Induced Pyrimidine Dimers

Although solar light is indispensable for the functioning of plants, this environmental factor may also cause damage to living cells. Apart from the visible range, including wavelengths used in photosynthesis, the ultraviolet (UV) light present in solar irradiation reaches the Earth’s surface. The h...

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Autores principales: Banaś, Agnieszka Katarzyna, Zgłobicki, Piotr, Kowalska, Ewa, Bażant, Aneta, Dziga, Dariusz, Strzałka, Wojciech
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7694213/
https://www.ncbi.nlm.nih.gov/pubmed/33158066
http://dx.doi.org/10.3390/genes11111304
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author Banaś, Agnieszka Katarzyna
Zgłobicki, Piotr
Kowalska, Ewa
Bażant, Aneta
Dziga, Dariusz
Strzałka, Wojciech
author_facet Banaś, Agnieszka Katarzyna
Zgłobicki, Piotr
Kowalska, Ewa
Bażant, Aneta
Dziga, Dariusz
Strzałka, Wojciech
author_sort Banaś, Agnieszka Katarzyna
collection PubMed
description Although solar light is indispensable for the functioning of plants, this environmental factor may also cause damage to living cells. Apart from the visible range, including wavelengths used in photosynthesis, the ultraviolet (UV) light present in solar irradiation reaches the Earth’s surface. The high energy of UV causes damage to many cellular components, with DNA as one of the targets. Putting together the puzzle-like elements responsible for the repair of UV-induced DNA damage is of special importance in understanding how plants ensure the stability of their genomes between generations. In this review, we have presented the information on DNA damage produced under UV with a special focus on the pyrimidine dimers formed between the neighboring pyrimidines in a DNA strand. These dimers are highly mutagenic and cytotoxic, thus their repair is essential for the maintenance of suitable genetic information. In prokaryotic and eukaryotic cells, with the exception of placental mammals, this is achieved by means of highly efficient photorepair, dependent on blue/UVA light, which is performed by specialized enzymes known as photolyases. Photolyase properties, as well as their structure, specificity and action mechanism, have been briefly discussed in this paper. Additionally, the main gaps in our knowledge on the functioning of light repair in plant organelles, its regulation and its interaction between different DNA repair systems in plants have been highlighted.
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spelling pubmed-76942132020-11-28 All You Need Is Light. Photorepair of UV-Induced Pyrimidine Dimers Banaś, Agnieszka Katarzyna Zgłobicki, Piotr Kowalska, Ewa Bażant, Aneta Dziga, Dariusz Strzałka, Wojciech Genes (Basel) Review Although solar light is indispensable for the functioning of plants, this environmental factor may also cause damage to living cells. Apart from the visible range, including wavelengths used in photosynthesis, the ultraviolet (UV) light present in solar irradiation reaches the Earth’s surface. The high energy of UV causes damage to many cellular components, with DNA as one of the targets. Putting together the puzzle-like elements responsible for the repair of UV-induced DNA damage is of special importance in understanding how plants ensure the stability of their genomes between generations. In this review, we have presented the information on DNA damage produced under UV with a special focus on the pyrimidine dimers formed between the neighboring pyrimidines in a DNA strand. These dimers are highly mutagenic and cytotoxic, thus their repair is essential for the maintenance of suitable genetic information. In prokaryotic and eukaryotic cells, with the exception of placental mammals, this is achieved by means of highly efficient photorepair, dependent on blue/UVA light, which is performed by specialized enzymes known as photolyases. Photolyase properties, as well as their structure, specificity and action mechanism, have been briefly discussed in this paper. Additionally, the main gaps in our knowledge on the functioning of light repair in plant organelles, its regulation and its interaction between different DNA repair systems in plants have been highlighted. MDPI 2020-11-04 /pmc/articles/PMC7694213/ /pubmed/33158066 http://dx.doi.org/10.3390/genes11111304 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Banaś, Agnieszka Katarzyna
Zgłobicki, Piotr
Kowalska, Ewa
Bażant, Aneta
Dziga, Dariusz
Strzałka, Wojciech
All You Need Is Light. Photorepair of UV-Induced Pyrimidine Dimers
title All You Need Is Light. Photorepair of UV-Induced Pyrimidine Dimers
title_full All You Need Is Light. Photorepair of UV-Induced Pyrimidine Dimers
title_fullStr All You Need Is Light. Photorepair of UV-Induced Pyrimidine Dimers
title_full_unstemmed All You Need Is Light. Photorepair of UV-Induced Pyrimidine Dimers
title_short All You Need Is Light. Photorepair of UV-Induced Pyrimidine Dimers
title_sort all you need is light. photorepair of uv-induced pyrimidine dimers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7694213/
https://www.ncbi.nlm.nih.gov/pubmed/33158066
http://dx.doi.org/10.3390/genes11111304
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