The CHEK2 Variant C.349A>G Is Associated with Prostate Cancer Risk and Carriers Share a Common Ancestor

SIMPLE SUMMARY: It is well-recognised the strong contribution of genetic factors to prostate cancer (PrCa) susceptibility, thus genetic screening is critical for presymptomatic diagnosis and identification of individuals at high-risk. In this context, recurrent founder variants in cancer predisposin...

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Autores principales: Brandão, Andreia, Paulo, Paula, Maia, Sofia, Pinheiro, Manuela, Peixoto, Ana, Cardoso, Marta, Silva, Maria P., Santos, Catarina, Eeles, Rosalind A., Kote-Jarai, Zsofia, Muir, Kenneth, Schleutker, Johanna, Wang, Ying, Pashayan, Nora, Batra, Jyotsna, Grönberg, Henrik, Neal, David E., Nordestgaard, Børge G., Tangen, Catherine M., Southey, Melissa C., Wolk, Alicja, Albanes, Demetrius, Haiman, Christopher A., Travis, Ruth C., Stanford, Janet L., Mucci, Lorelei A., West, Catharine M. L., Nielsen, Sune F., Kibel, Adam S., Cussenot, Olivier, Berndt, Sonja I., Koutros, Stella, Sørensen, Karina Dalsgaard, Cybulski, Cezary, Grindedal, Eli Marie, Park, Jong Y., Ingles, Sue A., Maier, Christiane, Hamilton, Robert J., Rosenstein, Barry S., Vega, Ana, Kogevinas, Manolis, Wiklund, Fredrik, Penney, Kathryn L., Brenner, Hermann, John, Esther M., Kaneva, Radka, Logothetis, Christopher J., Neuhausen, Susan L., Ruyck, Kim De, Razack, Azad, Newcomb, Lisa F., Lessel, Davor, Usmani, Nawaid, Claessens, Frank, Gago-Dominguez, Manuela, Townsend, Paul A., Roobol, Monique J., Teixeira, Manuel R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7694218/
https://www.ncbi.nlm.nih.gov/pubmed/33158149
http://dx.doi.org/10.3390/cancers12113254

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