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Nanoparticle-Based Approaches towards the Treatment of Atherosclerosis

Atherosclerosis, being an inflammation-associated disease, represents a considerable healthcare problem. Its origin remains poorly understood, and at the same time, it is associated with extensive morbidity and mortality worldwide due to myocardial infarctions and strokes. Unfortunately, drugs are u...

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Autores principales: Prilepskii, Artur Y., Serov, Nikita S., Kladko, Daniil V., Vinogradov, Vladimir V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7694323/
https://www.ncbi.nlm.nih.gov/pubmed/33167402
http://dx.doi.org/10.3390/pharmaceutics12111056
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author Prilepskii, Artur Y.
Serov, Nikita S.
Kladko, Daniil V.
Vinogradov, Vladimir V.
author_facet Prilepskii, Artur Y.
Serov, Nikita S.
Kladko, Daniil V.
Vinogradov, Vladimir V.
author_sort Prilepskii, Artur Y.
collection PubMed
description Atherosclerosis, being an inflammation-associated disease, represents a considerable healthcare problem. Its origin remains poorly understood, and at the same time, it is associated with extensive morbidity and mortality worldwide due to myocardial infarctions and strokes. Unfortunately, drugs are unable to effectively prevent plaque formation. Systemic administration of pharmaceuticals for the inhibition of plaque destabilization bears the risk of adverse effects. At present, nanoscience and, in particular, nanomedicine has made significant progress in both imaging and treatment of atherosclerosis. In this review, we focus on recent advances in this area, discussing subjects such as nanocarriers-based drug targeting principles, approaches towards the treatment of atherosclerosis, utilization of theranostic agents, and future prospects of nanoformulated therapeutics against atherosclerosis and inflammatory diseases. The focus is placed on articles published since 2015 with additional attention to research completed in 2019–2020.
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spelling pubmed-76943232020-11-28 Nanoparticle-Based Approaches towards the Treatment of Atherosclerosis Prilepskii, Artur Y. Serov, Nikita S. Kladko, Daniil V. Vinogradov, Vladimir V. Pharmaceutics Review Atherosclerosis, being an inflammation-associated disease, represents a considerable healthcare problem. Its origin remains poorly understood, and at the same time, it is associated with extensive morbidity and mortality worldwide due to myocardial infarctions and strokes. Unfortunately, drugs are unable to effectively prevent plaque formation. Systemic administration of pharmaceuticals for the inhibition of plaque destabilization bears the risk of adverse effects. At present, nanoscience and, in particular, nanomedicine has made significant progress in both imaging and treatment of atherosclerosis. In this review, we focus on recent advances in this area, discussing subjects such as nanocarriers-based drug targeting principles, approaches towards the treatment of atherosclerosis, utilization of theranostic agents, and future prospects of nanoformulated therapeutics against atherosclerosis and inflammatory diseases. The focus is placed on articles published since 2015 with additional attention to research completed in 2019–2020. MDPI 2020-11-05 /pmc/articles/PMC7694323/ /pubmed/33167402 http://dx.doi.org/10.3390/pharmaceutics12111056 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Prilepskii, Artur Y.
Serov, Nikita S.
Kladko, Daniil V.
Vinogradov, Vladimir V.
Nanoparticle-Based Approaches towards the Treatment of Atherosclerosis
title Nanoparticle-Based Approaches towards the Treatment of Atherosclerosis
title_full Nanoparticle-Based Approaches towards the Treatment of Atherosclerosis
title_fullStr Nanoparticle-Based Approaches towards the Treatment of Atherosclerosis
title_full_unstemmed Nanoparticle-Based Approaches towards the Treatment of Atherosclerosis
title_short Nanoparticle-Based Approaches towards the Treatment of Atherosclerosis
title_sort nanoparticle-based approaches towards the treatment of atherosclerosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7694323/
https://www.ncbi.nlm.nih.gov/pubmed/33167402
http://dx.doi.org/10.3390/pharmaceutics12111056
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