Cargando…

Disorders of Dental Hard Tissues Induced by Radioiodine-131 (I-131) Therapy Used in Differentiated Thyroid Cancer: An In Vitro Study

This study aimed to evaluate, in vitro, the effects of I-131 on enamel and dentin in healthy human incisive permanent maxillary teeth. Our in vitro model analogue with the in vivo conditions of differentiated thyroid carcinoma patients treated with I-131, consisted in a solution of I-131 dissolved i...

Descripción completa

Detalles Bibliográficos
Autores principales: Mester, Alexandru, Piciu, Andra, Piciu, Doina, Petean, Ioan, Lucaciu, Patricia Ondine, Apostu, Dragos, Moisescu-Goia, Cristina, Voina-Tonea, Andrada, Moldovan, Marioara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7694335/
https://www.ncbi.nlm.nih.gov/pubmed/33167338
http://dx.doi.org/10.3390/biomedicines8110475
_version_ 1783614953514598400
author Mester, Alexandru
Piciu, Andra
Piciu, Doina
Petean, Ioan
Lucaciu, Patricia Ondine
Apostu, Dragos
Moisescu-Goia, Cristina
Voina-Tonea, Andrada
Moldovan, Marioara
author_facet Mester, Alexandru
Piciu, Andra
Piciu, Doina
Petean, Ioan
Lucaciu, Patricia Ondine
Apostu, Dragos
Moisescu-Goia, Cristina
Voina-Tonea, Andrada
Moldovan, Marioara
author_sort Mester, Alexandru
collection PubMed
description This study aimed to evaluate, in vitro, the effects of I-131 on enamel and dentin in healthy human incisive permanent maxillary teeth. Our in vitro model analogue with the in vivo conditions of differentiated thyroid carcinoma patients treated with I-131, consisted in a solution of I-131 dissolved in artificial saliva. A total of 48 teeth were divided into eight groups (n = 6): control, irradiation groups at 3, 6, 12, 24, 36, 48, and 192 h, respectively. At the end of radiation exposure, radioiodine activity of specimens was assessed. Fine microstructure, nanostructure, surface roughness, and hidroxyapatite (HAP) crystallite diameter were investigated by atomic force microscopy (AFM) to both enamel and dentin structures. There is a constant increase of radioactivity in dental structures at 3, 6, 12, 24 h, due to progressive retention and I-131 migration, with a maximum at 36 h. Enamel showed notable alterations, which was correlated with the increase of the treatment time. A relevant visible distance between the HAP prisms was observed after 24 h. The surface suffered a loss in its compact structure. I-131 acts in the same way on HAP crystallites in dentin as in those in enamel. It was noticed that their morpho-dimensional changes occurred only after 12 h of treatment. Radioiodine-131 determines degradation of enamel and dentin by starting from the alteration of the crystalline network of HAP prisms, transforming them from compact materials into an agglomeration of rocky submicron structures.
format Online
Article
Text
id pubmed-7694335
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-76943352020-11-28 Disorders of Dental Hard Tissues Induced by Radioiodine-131 (I-131) Therapy Used in Differentiated Thyroid Cancer: An In Vitro Study Mester, Alexandru Piciu, Andra Piciu, Doina Petean, Ioan Lucaciu, Patricia Ondine Apostu, Dragos Moisescu-Goia, Cristina Voina-Tonea, Andrada Moldovan, Marioara Biomedicines Article This study aimed to evaluate, in vitro, the effects of I-131 on enamel and dentin in healthy human incisive permanent maxillary teeth. Our in vitro model analogue with the in vivo conditions of differentiated thyroid carcinoma patients treated with I-131, consisted in a solution of I-131 dissolved in artificial saliva. A total of 48 teeth were divided into eight groups (n = 6): control, irradiation groups at 3, 6, 12, 24, 36, 48, and 192 h, respectively. At the end of radiation exposure, radioiodine activity of specimens was assessed. Fine microstructure, nanostructure, surface roughness, and hidroxyapatite (HAP) crystallite diameter were investigated by atomic force microscopy (AFM) to both enamel and dentin structures. There is a constant increase of radioactivity in dental structures at 3, 6, 12, 24 h, due to progressive retention and I-131 migration, with a maximum at 36 h. Enamel showed notable alterations, which was correlated with the increase of the treatment time. A relevant visible distance between the HAP prisms was observed after 24 h. The surface suffered a loss in its compact structure. I-131 acts in the same way on HAP crystallites in dentin as in those in enamel. It was noticed that their morpho-dimensional changes occurred only after 12 h of treatment. Radioiodine-131 determines degradation of enamel and dentin by starting from the alteration of the crystalline network of HAP prisms, transforming them from compact materials into an agglomeration of rocky submicron structures. MDPI 2020-11-05 /pmc/articles/PMC7694335/ /pubmed/33167338 http://dx.doi.org/10.3390/biomedicines8110475 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mester, Alexandru
Piciu, Andra
Piciu, Doina
Petean, Ioan
Lucaciu, Patricia Ondine
Apostu, Dragos
Moisescu-Goia, Cristina
Voina-Tonea, Andrada
Moldovan, Marioara
Disorders of Dental Hard Tissues Induced by Radioiodine-131 (I-131) Therapy Used in Differentiated Thyroid Cancer: An In Vitro Study
title Disorders of Dental Hard Tissues Induced by Radioiodine-131 (I-131) Therapy Used in Differentiated Thyroid Cancer: An In Vitro Study
title_full Disorders of Dental Hard Tissues Induced by Radioiodine-131 (I-131) Therapy Used in Differentiated Thyroid Cancer: An In Vitro Study
title_fullStr Disorders of Dental Hard Tissues Induced by Radioiodine-131 (I-131) Therapy Used in Differentiated Thyroid Cancer: An In Vitro Study
title_full_unstemmed Disorders of Dental Hard Tissues Induced by Radioiodine-131 (I-131) Therapy Used in Differentiated Thyroid Cancer: An In Vitro Study
title_short Disorders of Dental Hard Tissues Induced by Radioiodine-131 (I-131) Therapy Used in Differentiated Thyroid Cancer: An In Vitro Study
title_sort disorders of dental hard tissues induced by radioiodine-131 (i-131) therapy used in differentiated thyroid cancer: an in vitro study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7694335/
https://www.ncbi.nlm.nih.gov/pubmed/33167338
http://dx.doi.org/10.3390/biomedicines8110475
work_keys_str_mv AT mesteralexandru disordersofdentalhardtissuesinducedbyradioiodine131i131therapyusedindifferentiatedthyroidcanceraninvitrostudy
AT piciuandra disordersofdentalhardtissuesinducedbyradioiodine131i131therapyusedindifferentiatedthyroidcanceraninvitrostudy
AT piciudoina disordersofdentalhardtissuesinducedbyradioiodine131i131therapyusedindifferentiatedthyroidcanceraninvitrostudy
AT peteanioan disordersofdentalhardtissuesinducedbyradioiodine131i131therapyusedindifferentiatedthyroidcanceraninvitrostudy
AT lucaciupatriciaondine disordersofdentalhardtissuesinducedbyradioiodine131i131therapyusedindifferentiatedthyroidcanceraninvitrostudy
AT apostudragos disordersofdentalhardtissuesinducedbyradioiodine131i131therapyusedindifferentiatedthyroidcanceraninvitrostudy
AT moisescugoiacristina disordersofdentalhardtissuesinducedbyradioiodine131i131therapyusedindifferentiatedthyroidcanceraninvitrostudy
AT voinatoneaandrada disordersofdentalhardtissuesinducedbyradioiodine131i131therapyusedindifferentiatedthyroidcanceraninvitrostudy
AT moldovanmarioara disordersofdentalhardtissuesinducedbyradioiodine131i131therapyusedindifferentiatedthyroidcanceraninvitrostudy