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Astrocyte-derived clusterin suppresses amyloid formation in vivo

BACKGROUND: Accumulation of amyloid-β (Aβ) peptide in the brain is a pathological hallmark of Alzheimer’s disease (AD). The clusterin (CLU) gene confers a risk for AD and CLU is highly upregulated in AD patients, with the common non-coding, protective CLU variants associated with increased expressio...

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Detalles Bibliográficos
Autores principales:	Wojtas, Aleksandra M., Sens, Jonathon P., Kang, Silvia S., Baker, Kelsey E., Berry, Taylor J., Kurti, Aishe, Daughrity, Lillian, Jansen-West, Karen R., Dickson, Dennis W., Petrucelli, Leonard, Bu, Guojun, Liu, Chia-Chen, Fryer, John D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7694353/ https://www.ncbi.nlm.nih.gov/pubmed/33246484 http://dx.doi.org/10.1186/s13024-020-00416-1

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