Myeloma Cells Deplete Bone Marrow Glutamine and Inhibit Osteoblast Differentiation Limiting Asparagine Availability

SIMPLE SUMMARY: Osteolytic bone lesions represent an important clinical feature of multiple myeloma (MM). MM cells metabolize very high amounts of glutamine (Gln) and significantly lower Gln in the bone marrow. In this contribution we demonstrate that MM-dependent Gln depletion impairs the different...

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Autores principales: Chiu, Martina, Toscani, Denise, Marchica, Valentina, Taurino, Giuseppe, Costa, Federica, Bianchi, Massimiliano G., Andreoli, Roberta, Franceschi, Valentina, Storti, Paola, Burroughs-Garcia, Jessica, Eufemiese, Rosa Alba, Dalla Palma, Benedetta, Campanini, Nicoletta, Martella, Eugenia, Mancini, Cristina, Shan, Jixiu, Kilberg, Michael S., D’Amico, Giovanna, Dander, Erica, Agnelli, Luca, Pruneri, Giancarlo, Donofrio, Gaetano, Bussolati, Ovidio, Giuliani, Nicola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7694402/
https://www.ncbi.nlm.nih.gov/pubmed/33167336
http://dx.doi.org/10.3390/cancers12113267

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