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Histone Variants: Guardians of Genome Integrity
Chromatin integrity is key for cell homeostasis and for preventing pathological development. Alterations in core chromatin components, histone proteins, recently came into the spotlight through the discovery of their driving role in cancer. Building on these findings, in this review, we discuss how...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7694513/ https://www.ncbi.nlm.nih.gov/pubmed/33167489 http://dx.doi.org/10.3390/cells9112424 |
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author | Ferrand, Juliette Rondinelli, Beatrice Polo, Sophie E. |
author_facet | Ferrand, Juliette Rondinelli, Beatrice Polo, Sophie E. |
author_sort | Ferrand, Juliette |
collection | PubMed |
description | Chromatin integrity is key for cell homeostasis and for preventing pathological development. Alterations in core chromatin components, histone proteins, recently came into the spotlight through the discovery of their driving role in cancer. Building on these findings, in this review, we discuss how histone variants and their associated chaperones safeguard genome stability and protect against tumorigenesis. Accumulating evidence supports the contribution of histone variants and their chaperones to the maintenance of chromosomal integrity and to various steps of the DNA damage response, including damaged chromatin dynamics, DNA damage repair, and damage-dependent transcription regulation. We present our current knowledge on these topics and review recent advances in deciphering how alterations in histone variant sequence, expression, and deposition into chromatin fuel oncogenic transformation by impacting cell proliferation and cell fate transitions. We also highlight open questions and upcoming challenges in this rapidly growing field. |
format | Online Article Text |
id | pubmed-7694513 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-76945132020-11-28 Histone Variants: Guardians of Genome Integrity Ferrand, Juliette Rondinelli, Beatrice Polo, Sophie E. Cells Review Chromatin integrity is key for cell homeostasis and for preventing pathological development. Alterations in core chromatin components, histone proteins, recently came into the spotlight through the discovery of their driving role in cancer. Building on these findings, in this review, we discuss how histone variants and their associated chaperones safeguard genome stability and protect against tumorigenesis. Accumulating evidence supports the contribution of histone variants and their chaperones to the maintenance of chromosomal integrity and to various steps of the DNA damage response, including damaged chromatin dynamics, DNA damage repair, and damage-dependent transcription regulation. We present our current knowledge on these topics and review recent advances in deciphering how alterations in histone variant sequence, expression, and deposition into chromatin fuel oncogenic transformation by impacting cell proliferation and cell fate transitions. We also highlight open questions and upcoming challenges in this rapidly growing field. MDPI 2020-11-05 /pmc/articles/PMC7694513/ /pubmed/33167489 http://dx.doi.org/10.3390/cells9112424 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Ferrand, Juliette Rondinelli, Beatrice Polo, Sophie E. Histone Variants: Guardians of Genome Integrity |
title | Histone Variants: Guardians of Genome Integrity |
title_full | Histone Variants: Guardians of Genome Integrity |
title_fullStr | Histone Variants: Guardians of Genome Integrity |
title_full_unstemmed | Histone Variants: Guardians of Genome Integrity |
title_short | Histone Variants: Guardians of Genome Integrity |
title_sort | histone variants: guardians of genome integrity |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7694513/ https://www.ncbi.nlm.nih.gov/pubmed/33167489 http://dx.doi.org/10.3390/cells9112424 |
work_keys_str_mv | AT ferrandjuliette histonevariantsguardiansofgenomeintegrity AT rondinellibeatrice histonevariantsguardiansofgenomeintegrity AT polosophiee histonevariantsguardiansofgenomeintegrity |