Cargando…

Histone Variants: Guardians of Genome Integrity

Chromatin integrity is key for cell homeostasis and for preventing pathological development. Alterations in core chromatin components, histone proteins, recently came into the spotlight through the discovery of their driving role in cancer. Building on these findings, in this review, we discuss how...

Descripción completa

Detalles Bibliográficos
Autores principales: Ferrand, Juliette, Rondinelli, Beatrice, Polo, Sophie E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7694513/
https://www.ncbi.nlm.nih.gov/pubmed/33167489
http://dx.doi.org/10.3390/cells9112424
_version_ 1783614993670864896
author Ferrand, Juliette
Rondinelli, Beatrice
Polo, Sophie E.
author_facet Ferrand, Juliette
Rondinelli, Beatrice
Polo, Sophie E.
author_sort Ferrand, Juliette
collection PubMed
description Chromatin integrity is key for cell homeostasis and for preventing pathological development. Alterations in core chromatin components, histone proteins, recently came into the spotlight through the discovery of their driving role in cancer. Building on these findings, in this review, we discuss how histone variants and their associated chaperones safeguard genome stability and protect against tumorigenesis. Accumulating evidence supports the contribution of histone variants and their chaperones to the maintenance of chromosomal integrity and to various steps of the DNA damage response, including damaged chromatin dynamics, DNA damage repair, and damage-dependent transcription regulation. We present our current knowledge on these topics and review recent advances in deciphering how alterations in histone variant sequence, expression, and deposition into chromatin fuel oncogenic transformation by impacting cell proliferation and cell fate transitions. We also highlight open questions and upcoming challenges in this rapidly growing field.
format Online
Article
Text
id pubmed-7694513
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-76945132020-11-28 Histone Variants: Guardians of Genome Integrity Ferrand, Juliette Rondinelli, Beatrice Polo, Sophie E. Cells Review Chromatin integrity is key for cell homeostasis and for preventing pathological development. Alterations in core chromatin components, histone proteins, recently came into the spotlight through the discovery of their driving role in cancer. Building on these findings, in this review, we discuss how histone variants and their associated chaperones safeguard genome stability and protect against tumorigenesis. Accumulating evidence supports the contribution of histone variants and their chaperones to the maintenance of chromosomal integrity and to various steps of the DNA damage response, including damaged chromatin dynamics, DNA damage repair, and damage-dependent transcription regulation. We present our current knowledge on these topics and review recent advances in deciphering how alterations in histone variant sequence, expression, and deposition into chromatin fuel oncogenic transformation by impacting cell proliferation and cell fate transitions. We also highlight open questions and upcoming challenges in this rapidly growing field. MDPI 2020-11-05 /pmc/articles/PMC7694513/ /pubmed/33167489 http://dx.doi.org/10.3390/cells9112424 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ferrand, Juliette
Rondinelli, Beatrice
Polo, Sophie E.
Histone Variants: Guardians of Genome Integrity
title Histone Variants: Guardians of Genome Integrity
title_full Histone Variants: Guardians of Genome Integrity
title_fullStr Histone Variants: Guardians of Genome Integrity
title_full_unstemmed Histone Variants: Guardians of Genome Integrity
title_short Histone Variants: Guardians of Genome Integrity
title_sort histone variants: guardians of genome integrity
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7694513/
https://www.ncbi.nlm.nih.gov/pubmed/33167489
http://dx.doi.org/10.3390/cells9112424
work_keys_str_mv AT ferrandjuliette histonevariantsguardiansofgenomeintegrity
AT rondinellibeatrice histonevariantsguardiansofgenomeintegrity
AT polosophiee histonevariantsguardiansofgenomeintegrity