Cargando…
The Role of Obesity in Early and Long-Term Outcomes after Surgical Excision of Lung Oligometastases from Colorectal Cancer
Obesity correlates with better outcomes in many neoplastic conditions. The aim of this study was to assess its role in the prognosis and morbidity of patients submitted to resection of lung oligometastases from colorectal cancer. Seventy-six patients undergoing a first pulmonary metastasectomy were...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7694523/ https://www.ncbi.nlm.nih.gov/pubmed/33167545 http://dx.doi.org/10.3390/jcm9113566 |
_version_ | 1783614995985072128 |
---|---|
author | Londero, Francesco Parise, Orlando Grossi, William Morelli, Angelo Masullo, Gianluca Bartoletti, Michele Tetta, Cecilia Livi, Ugolino Maessen, Jos G. Gelsomino, Sandro |
author_facet | Londero, Francesco Parise, Orlando Grossi, William Morelli, Angelo Masullo, Gianluca Bartoletti, Michele Tetta, Cecilia Livi, Ugolino Maessen, Jos G. Gelsomino, Sandro |
author_sort | Londero, Francesco |
collection | PubMed |
description | Obesity correlates with better outcomes in many neoplastic conditions. The aim of this study was to assess its role in the prognosis and morbidity of patients submitted to resection of lung oligometastases from colorectal cancer. Seventy-six patients undergoing a first pulmonary metastasectomy were retrospectively included in the study. Seventeen (22.3%) were obese (body mass index (BMI) >30 kg/m(2)). Assessed outcomes were overall survival, time to recurrence, and incidence of post-operative complications. Median follow-up was 33 months (IQR 16–53). At follow-up, 37 patients (48.6%) died, whereas 39 (51.4%) were alive. A significant difference was found in the 3-year overall survival (obese 80% vs. non-obese 56.8%, p = 0.035). Competing risk analysis shows that the cumulative incidence of recurrence was not different between the two groups. Multivariate analysis reveals that the number of metastases (p = 0.028), post-operative pneumonia (p = 0.042), and DFS (p = 0.007) were significant predictors of death. Competing risk regression shows that no independent risk factor for recurrence has been identified. The complication rate was not different between the two groups (17.6% vs. 13.6%, p = 0.70). Obesity is a positive prognostic factor for survival after pulmonary metastasectomy for colorectal cancer. Overweight patients do not experience more post-operative complications. Our results need to be confirmed by large multicenter studies. |
format | Online Article Text |
id | pubmed-7694523 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-76945232020-11-28 The Role of Obesity in Early and Long-Term Outcomes after Surgical Excision of Lung Oligometastases from Colorectal Cancer Londero, Francesco Parise, Orlando Grossi, William Morelli, Angelo Masullo, Gianluca Bartoletti, Michele Tetta, Cecilia Livi, Ugolino Maessen, Jos G. Gelsomino, Sandro J Clin Med Article Obesity correlates with better outcomes in many neoplastic conditions. The aim of this study was to assess its role in the prognosis and morbidity of patients submitted to resection of lung oligometastases from colorectal cancer. Seventy-six patients undergoing a first pulmonary metastasectomy were retrospectively included in the study. Seventeen (22.3%) were obese (body mass index (BMI) >30 kg/m(2)). Assessed outcomes were overall survival, time to recurrence, and incidence of post-operative complications. Median follow-up was 33 months (IQR 16–53). At follow-up, 37 patients (48.6%) died, whereas 39 (51.4%) were alive. A significant difference was found in the 3-year overall survival (obese 80% vs. non-obese 56.8%, p = 0.035). Competing risk analysis shows that the cumulative incidence of recurrence was not different between the two groups. Multivariate analysis reveals that the number of metastases (p = 0.028), post-operative pneumonia (p = 0.042), and DFS (p = 0.007) were significant predictors of death. Competing risk regression shows that no independent risk factor for recurrence has been identified. The complication rate was not different between the two groups (17.6% vs. 13.6%, p = 0.70). Obesity is a positive prognostic factor for survival after pulmonary metastasectomy for colorectal cancer. Overweight patients do not experience more post-operative complications. Our results need to be confirmed by large multicenter studies. MDPI 2020-11-05 /pmc/articles/PMC7694523/ /pubmed/33167545 http://dx.doi.org/10.3390/jcm9113566 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Londero, Francesco Parise, Orlando Grossi, William Morelli, Angelo Masullo, Gianluca Bartoletti, Michele Tetta, Cecilia Livi, Ugolino Maessen, Jos G. Gelsomino, Sandro The Role of Obesity in Early and Long-Term Outcomes after Surgical Excision of Lung Oligometastases from Colorectal Cancer |
title | The Role of Obesity in Early and Long-Term Outcomes after Surgical Excision of Lung Oligometastases from Colorectal Cancer |
title_full | The Role of Obesity in Early and Long-Term Outcomes after Surgical Excision of Lung Oligometastases from Colorectal Cancer |
title_fullStr | The Role of Obesity in Early and Long-Term Outcomes after Surgical Excision of Lung Oligometastases from Colorectal Cancer |
title_full_unstemmed | The Role of Obesity in Early and Long-Term Outcomes after Surgical Excision of Lung Oligometastases from Colorectal Cancer |
title_short | The Role of Obesity in Early and Long-Term Outcomes after Surgical Excision of Lung Oligometastases from Colorectal Cancer |
title_sort | role of obesity in early and long-term outcomes after surgical excision of lung oligometastases from colorectal cancer |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7694523/ https://www.ncbi.nlm.nih.gov/pubmed/33167545 http://dx.doi.org/10.3390/jcm9113566 |
work_keys_str_mv | AT londerofrancesco theroleofobesityinearlyandlongtermoutcomesaftersurgicalexcisionoflungoligometastasesfromcolorectalcancer AT pariseorlando theroleofobesityinearlyandlongtermoutcomesaftersurgicalexcisionoflungoligometastasesfromcolorectalcancer AT grossiwilliam theroleofobesityinearlyandlongtermoutcomesaftersurgicalexcisionoflungoligometastasesfromcolorectalcancer AT morelliangelo theroleofobesityinearlyandlongtermoutcomesaftersurgicalexcisionoflungoligometastasesfromcolorectalcancer AT masullogianluca theroleofobesityinearlyandlongtermoutcomesaftersurgicalexcisionoflungoligometastasesfromcolorectalcancer AT bartolettimichele theroleofobesityinearlyandlongtermoutcomesaftersurgicalexcisionoflungoligometastasesfromcolorectalcancer AT tettacecilia theroleofobesityinearlyandlongtermoutcomesaftersurgicalexcisionoflungoligometastasesfromcolorectalcancer AT liviugolino theroleofobesityinearlyandlongtermoutcomesaftersurgicalexcisionoflungoligometastasesfromcolorectalcancer AT maessenjosg theroleofobesityinearlyandlongtermoutcomesaftersurgicalexcisionoflungoligometastasesfromcolorectalcancer AT gelsominosandro theroleofobesityinearlyandlongtermoutcomesaftersurgicalexcisionoflungoligometastasesfromcolorectalcancer AT londerofrancesco roleofobesityinearlyandlongtermoutcomesaftersurgicalexcisionoflungoligometastasesfromcolorectalcancer AT pariseorlando roleofobesityinearlyandlongtermoutcomesaftersurgicalexcisionoflungoligometastasesfromcolorectalcancer AT grossiwilliam roleofobesityinearlyandlongtermoutcomesaftersurgicalexcisionoflungoligometastasesfromcolorectalcancer AT morelliangelo roleofobesityinearlyandlongtermoutcomesaftersurgicalexcisionoflungoligometastasesfromcolorectalcancer AT masullogianluca roleofobesityinearlyandlongtermoutcomesaftersurgicalexcisionoflungoligometastasesfromcolorectalcancer AT bartolettimichele roleofobesityinearlyandlongtermoutcomesaftersurgicalexcisionoflungoligometastasesfromcolorectalcancer AT tettacecilia roleofobesityinearlyandlongtermoutcomesaftersurgicalexcisionoflungoligometastasesfromcolorectalcancer AT liviugolino roleofobesityinearlyandlongtermoutcomesaftersurgicalexcisionoflungoligometastasesfromcolorectalcancer AT maessenjosg roleofobesityinearlyandlongtermoutcomesaftersurgicalexcisionoflungoligometastasesfromcolorectalcancer AT gelsominosandro roleofobesityinearlyandlongtermoutcomesaftersurgicalexcisionoflungoligometastasesfromcolorectalcancer |