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The Role of Obesity in Early and Long-Term Outcomes after Surgical Excision of Lung Oligometastases from Colorectal Cancer

Obesity correlates with better outcomes in many neoplastic conditions. The aim of this study was to assess its role in the prognosis and morbidity of patients submitted to resection of lung oligometastases from colorectal cancer. Seventy-six patients undergoing a first pulmonary metastasectomy were...

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Autores principales: Londero, Francesco, Parise, Orlando, Grossi, William, Morelli, Angelo, Masullo, Gianluca, Bartoletti, Michele, Tetta, Cecilia, Livi, Ugolino, Maessen, Jos G., Gelsomino, Sandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7694523/
https://www.ncbi.nlm.nih.gov/pubmed/33167545
http://dx.doi.org/10.3390/jcm9113566
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author Londero, Francesco
Parise, Orlando
Grossi, William
Morelli, Angelo
Masullo, Gianluca
Bartoletti, Michele
Tetta, Cecilia
Livi, Ugolino
Maessen, Jos G.
Gelsomino, Sandro
author_facet Londero, Francesco
Parise, Orlando
Grossi, William
Morelli, Angelo
Masullo, Gianluca
Bartoletti, Michele
Tetta, Cecilia
Livi, Ugolino
Maessen, Jos G.
Gelsomino, Sandro
author_sort Londero, Francesco
collection PubMed
description Obesity correlates with better outcomes in many neoplastic conditions. The aim of this study was to assess its role in the prognosis and morbidity of patients submitted to resection of lung oligometastases from colorectal cancer. Seventy-six patients undergoing a first pulmonary metastasectomy were retrospectively included in the study. Seventeen (22.3%) were obese (body mass index (BMI) >30 kg/m(2)). Assessed outcomes were overall survival, time to recurrence, and incidence of post-operative complications. Median follow-up was 33 months (IQR 16–53). At follow-up, 37 patients (48.6%) died, whereas 39 (51.4%) were alive. A significant difference was found in the 3-year overall survival (obese 80% vs. non-obese 56.8%, p = 0.035). Competing risk analysis shows that the cumulative incidence of recurrence was not different between the two groups. Multivariate analysis reveals that the number of metastases (p = 0.028), post-operative pneumonia (p = 0.042), and DFS (p = 0.007) were significant predictors of death. Competing risk regression shows that no independent risk factor for recurrence has been identified. The complication rate was not different between the two groups (17.6% vs. 13.6%, p = 0.70). Obesity is a positive prognostic factor for survival after pulmonary metastasectomy for colorectal cancer. Overweight patients do not experience more post-operative complications. Our results need to be confirmed by large multicenter studies.
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spelling pubmed-76945232020-11-28 The Role of Obesity in Early and Long-Term Outcomes after Surgical Excision of Lung Oligometastases from Colorectal Cancer Londero, Francesco Parise, Orlando Grossi, William Morelli, Angelo Masullo, Gianluca Bartoletti, Michele Tetta, Cecilia Livi, Ugolino Maessen, Jos G. Gelsomino, Sandro J Clin Med Article Obesity correlates with better outcomes in many neoplastic conditions. The aim of this study was to assess its role in the prognosis and morbidity of patients submitted to resection of lung oligometastases from colorectal cancer. Seventy-six patients undergoing a first pulmonary metastasectomy were retrospectively included in the study. Seventeen (22.3%) were obese (body mass index (BMI) >30 kg/m(2)). Assessed outcomes were overall survival, time to recurrence, and incidence of post-operative complications. Median follow-up was 33 months (IQR 16–53). At follow-up, 37 patients (48.6%) died, whereas 39 (51.4%) were alive. A significant difference was found in the 3-year overall survival (obese 80% vs. non-obese 56.8%, p = 0.035). Competing risk analysis shows that the cumulative incidence of recurrence was not different between the two groups. Multivariate analysis reveals that the number of metastases (p = 0.028), post-operative pneumonia (p = 0.042), and DFS (p = 0.007) were significant predictors of death. Competing risk regression shows that no independent risk factor for recurrence has been identified. The complication rate was not different between the two groups (17.6% vs. 13.6%, p = 0.70). Obesity is a positive prognostic factor for survival after pulmonary metastasectomy for colorectal cancer. Overweight patients do not experience more post-operative complications. Our results need to be confirmed by large multicenter studies. MDPI 2020-11-05 /pmc/articles/PMC7694523/ /pubmed/33167545 http://dx.doi.org/10.3390/jcm9113566 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Londero, Francesco
Parise, Orlando
Grossi, William
Morelli, Angelo
Masullo, Gianluca
Bartoletti, Michele
Tetta, Cecilia
Livi, Ugolino
Maessen, Jos G.
Gelsomino, Sandro
The Role of Obesity in Early and Long-Term Outcomes after Surgical Excision of Lung Oligometastases from Colorectal Cancer
title The Role of Obesity in Early and Long-Term Outcomes after Surgical Excision of Lung Oligometastases from Colorectal Cancer
title_full The Role of Obesity in Early and Long-Term Outcomes after Surgical Excision of Lung Oligometastases from Colorectal Cancer
title_fullStr The Role of Obesity in Early and Long-Term Outcomes after Surgical Excision of Lung Oligometastases from Colorectal Cancer
title_full_unstemmed The Role of Obesity in Early and Long-Term Outcomes after Surgical Excision of Lung Oligometastases from Colorectal Cancer
title_short The Role of Obesity in Early and Long-Term Outcomes after Surgical Excision of Lung Oligometastases from Colorectal Cancer
title_sort role of obesity in early and long-term outcomes after surgical excision of lung oligometastases from colorectal cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7694523/
https://www.ncbi.nlm.nih.gov/pubmed/33167545
http://dx.doi.org/10.3390/jcm9113566
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