Cargando…

Molecular Dynamics Studies of Poly(Lactic Acid) Nanoparticles and Their Interactions with Vitamin E and TLR Agonists Pam(1)CSK(4) and Pam(3)CSK(4)

Poly(lactic acid) (PLA) nanoparticles (NPs) are widely investigated due to their bioresorbable, biocompatible and low immunogen properties. Interestingly, many recent studies show that they can be efficiently used as drug delivery systems or as adjuvants to enhance vaccine efficacy. Our work focuses...

Descripción completa

Detalles Bibliográficos
Autores principales:	Megy, Simon, Aguero, Stephanie, Da Costa, David, Lamrayah, Myriam, Berthet, Morgane, Primard, Charlotte, Verrier, Bernard, Terreux, Raphael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7694526/ https://www.ncbi.nlm.nih.gov/pubmed/33167538 http://dx.doi.org/10.3390/nano10112209

Ejemplares similares

An efficient and scalable synthesis of potent TLR2 agonistic PAM(2)CSK(4)
por: Kaur, Arshpreet, et al.
Publicado: (2018)

Coinjection with TLR2 Agonist Pam3CSK4 Reduces the Pathology of Leishmanization in Mice
por: Huang, Lu, et al.
Publicado: (2015)

Control of Methicillin-Resistant Staphylococcus aureus Pneumonia Utilizing TLR2 Agonist Pam3CSK4
por: Chen, Yi-Guo, et al.
Publicado: (2016)

The Synthetic Bacterial Lipopeptide Pam3CSK4 Modulates Respiratory Syncytial Virus Infection Independent of TLR Activation
por: Nguyen, D. Tien, et al.
Publicado: (2010)

A20 Is Critical for the Induction of Pam3CSK4-Tolerance in Monocytic THP-1 Cells
por: Hu, Jinyue, et al.
Publicado: (2014)

Combination of poly I:C and Pam3CSK4 enhances activation of B cells in vitro and boosts antibody responses to protein vaccines in vivo
por: Weir, Genevieve M., et al.
Publicado: (2017)

The inflammatory cytokine effect of Pam3CSK4 TLR2 agonist alone or in combination with Leishmania infantum antigen on ex-vivo whole blood from sick and resistant dogs
por: Martínez-Orellana, Pamela, et al.
Publicado: (2017)

The TLR2/6 ligand PAM2CSK4 is a Th2 polarizing adjuvant in Leishmania major and Brugia malayi murine vaccine models
por: Halliday, Alice, et al.
Publicado: (2016)

Differential Effects of the Toll-Like Receptor 2 Agonists, PGN and Pam3CSK4 on Anti-IgE Induced Human Mast Cell Activation
por: Yu, Yangyang, et al.
Publicado: (2014)

Adjuvant Pam3CSk4 does not improve the immunization against Cryptococcus gattii infection in C57BL/6 mice
por: de Campos, Gabriela Yamazaki, et al.
Publicado: (2023)

Pam2CSK4-adjuvanted SARS-CoV-2 RBD nanoparticle vaccine induces robust humoral and cellular immune responses
por: Qiao, Yidan, et al.
Publicado: (2022)

Xuebijing Injection Alleviates Pam3CSK4-Induced Inflammatory Response and Protects Mice From Sepsis Caused by Methicillin-Resistant Staphylococcus aureus
por: Li, Tiantian, et al.
Publicado: (2020)

Siegesbeckia pubescens Makino inhibits Pam(3)CSK(4)-induced inflammation in RAW 264.7 macrophages through suppressing TLR1/TLR2-mediated NF-κB activation
por: Sang, Wei, et al.
Publicado: (2018)

TLR2 Ligand Pam3CSK4 Regulates MMP-2/9 Expression by MAPK/NF-κB Signaling Pathways in Primary Brain Microvascular Endothelial Cells
por: Zhu, Hongyan, et al.
Publicado: (2018)

Evaluation of different combination of pam2CSK4, poly (I:C) and imiquimod enhance immune responses to H9N2 avian influenza antigen in dendritic cells and duck
por: Zhang, Aiguo, et al.
Publicado: (2022)

Pro-inflammatory response ensured by LPS and Pam3CSK4 in RAW 264.7 cells did not improve a fungistatic effect on Cryptococcus gattii infection
por: de Campos, Gabriela Yamazaki, et al.
Publicado: (2020)

Regulation, targets and functions of CSK
por: Zhu, Shudong, et al.
Publicado: (2023)

Toll-like Receptor 1/2 Agonist Pam3CSK4 Suppresses Lipopolysaccharide-driven IgG1 Production while Enhancing IgG2a Production by B Cells
por: Lee, Sang-Hoon, et al.
Publicado: (2018)

Regulation of the Src Family Kinases by Csk
por: Okada, Masato
Publicado: (2012)

CSK-mediated signalling by integrins in cancer
por: Maldonado, Horacio, et al.
Publicado: (2023)

Editorial: Regulation and dysfunction of CSK and CHK
por: Zhu, Shudong, et al.
Publicado: (2023)

The Toll-Like Receptor 2 Ligand Pam2CSK4 Activates Platelet Nuclear Factor-κB and Bruton’s Tyrosine Kinase Signaling to Promote Platelet-Endothelial Cell Interactions
por: Parra-Izquierdo, Iván, et al.
Publicado: (2021)

Mitotic Activation of c‐Src Is Suppressed by Csk
por: Ohsato, Yoshiharu, et al.
Publicado: (1994)

Apoptosis regulation by the tyrosine-protein kinase CSK
por: Fortner, Andra, et al.
Publicado: (2022)

Gene Silencing and Haploinsufficiency of Csk Increase Blood Pressure
por: Lee, Hyeon-Ju, et al.
Publicado: (2016)

LYP inhibits T cell activation when dissociated from CSK
por: Vang, Torkel, et al.
Publicado: (2012)

Small molecule inhibition of Csk alters affinity recognition by T cells
por: Manz, Boryana N, et al.
Publicado: (2015)

SUMOylation of Csk Negatively Modulates its Tumor Suppressor Function
por: Cui, Nan, et al.
Publicado: (2019)

Effects of the TLR2 Agonists MALP-2 and Pam(3)Cys in Isolated Mouse Lungs
por: Barrenschee, Martina, et al.
Publicado: (2010)

The Tyrosine Kinase Csk Dimerizes through Its SH3 Domain
por: Levinson, Nicholas M., et al.
Publicado: (2009)

Regulation of Src and Csk Nonreceptor Tyrosine Kinases in the Filasterean Ministeria vibrans
por: Schultheiss, Kira P., et al.
Publicado: (2014)

IL-4 and IL-13 induce Lsk, a Csk-like tyrosine kinase, in human monocytes
Publicado: (1994)

The LEPSIS Pam-File
por: DELPHI Collaboration
Publicado: (1982)

Connexin43 recruits PTEN and Csk to inhibit c-Src activity in glioma cells and astrocytes
por: González-Sánchez, Ana, et al.
Publicado: (2016)

Positive and Negative Regulatory Roles of C-Terminal Src Kinase (CSK) in FcεRI-Mediated Mast Cell Activation, Independent of the Transmembrane Adaptor PAG/CSK-Binding Protein
por: Potuckova, Lucie, et al.
Publicado: (2018)

A phospho-tyrosine–based signaling module using SPOP, CSK, and LYN controls TLR-induced IRF activity
por: Tawaratsumida, Kazuki, et al.
Publicado: (2022)

Control of lymphopoiesis by p50csk, a regulatory protein tyrosine kinase
Publicado: (1995)

TRAF3 enhances TCR signaling by regulating the inhibitors Csk and PTPN22
por: Wallis, Alicia M., et al.
Publicado: (2017)

Dissection of the catalytic and regulatory structure-function relationships of Csk protein tyrosine kinase
por: Sun, Gongqin, et al.
Publicado: (2023)

Modifications to the LEPSIM Pam-File
por: DELPHI Collaboration
Publicado: (1982)

Cannot write session to /tmp/vufind_sessions/sess_hinphidfgf0ckhdcfdns10kkh8