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Can Zika Virus Infection in High Risk Pregnant Women Be Differentiated on the Basis of Symptoms?

Zika virus (ZIKV) infection in pregnancy is associated with congenital neurological abnormalities. Our understanding of the full clinical spectrum of ZIKV infection is incomplete. Using data from this prospective cohort study consisting of 650 women attending a high-risk pregnancy clinic during the...

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Autores principales: Sanchez Clemente, Nuria, Brickley, Elizabeth B., Furquim de Almeida, Marcia, Witkin, Steven S., Duarte Passos, Saulo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7694531/
https://www.ncbi.nlm.nih.gov/pubmed/33167566
http://dx.doi.org/10.3390/v12111263
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author Sanchez Clemente, Nuria
Brickley, Elizabeth B.
Furquim de Almeida, Marcia
Witkin, Steven S.
Duarte Passos, Saulo
author_facet Sanchez Clemente, Nuria
Brickley, Elizabeth B.
Furquim de Almeida, Marcia
Witkin, Steven S.
Duarte Passos, Saulo
author_sort Sanchez Clemente, Nuria
collection PubMed
description Zika virus (ZIKV) infection in pregnancy is associated with congenital neurological abnormalities. Our understanding of the full clinical spectrum of ZIKV infection is incomplete. Using data from this prospective cohort study consisting of 650 women attending a high-risk pregnancy clinic during the Zika virus outbreak in Brazil, we investigated the extent to which specific symptoms can be utilized to differentiate ZIKV-infected pregnant women from those with other pregnancy-related problems. All were tested for ZIKV in urine by RT–qPCR. Demographic and clinical data including physical symptoms during follow-up were recorded and analyzed with respect to Zika virus exposure status. Forty-eight (7.4%) women were positive for ZIKV by RT–qPCR. The majority (70.8%) were asymptomatic, and only four ZIKV-positive women (8.3%) reported symptoms during pregnancy that met the WHO case definition. Zika-positive and -negative women reported similar frequencies of ZIKV-like symptoms (as per the WHO definition): fever (16.7% vs. 13.6%), arthralgia/arthritis (10.4% vs. 11.3%), rash (4.2% vs. 5.3%), and conjunctivitis (2.1% vs. 3.2%). Most pregnant women positive for ZIKV in urine are asymptomatic and do not deliver a baby with microcephaly. Physical symptoms alone did not differentiate between high-risk pregnant women positive or negative for ZIKV.
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spelling pubmed-76945312020-11-28 Can Zika Virus Infection in High Risk Pregnant Women Be Differentiated on the Basis of Symptoms? Sanchez Clemente, Nuria Brickley, Elizabeth B. Furquim de Almeida, Marcia Witkin, Steven S. Duarte Passos, Saulo Viruses Article Zika virus (ZIKV) infection in pregnancy is associated with congenital neurological abnormalities. Our understanding of the full clinical spectrum of ZIKV infection is incomplete. Using data from this prospective cohort study consisting of 650 women attending a high-risk pregnancy clinic during the Zika virus outbreak in Brazil, we investigated the extent to which specific symptoms can be utilized to differentiate ZIKV-infected pregnant women from those with other pregnancy-related problems. All were tested for ZIKV in urine by RT–qPCR. Demographic and clinical data including physical symptoms during follow-up were recorded and analyzed with respect to Zika virus exposure status. Forty-eight (7.4%) women were positive for ZIKV by RT–qPCR. The majority (70.8%) were asymptomatic, and only four ZIKV-positive women (8.3%) reported symptoms during pregnancy that met the WHO case definition. Zika-positive and -negative women reported similar frequencies of ZIKV-like symptoms (as per the WHO definition): fever (16.7% vs. 13.6%), arthralgia/arthritis (10.4% vs. 11.3%), rash (4.2% vs. 5.3%), and conjunctivitis (2.1% vs. 3.2%). Most pregnant women positive for ZIKV in urine are asymptomatic and do not deliver a baby with microcephaly. Physical symptoms alone did not differentiate between high-risk pregnant women positive or negative for ZIKV. MDPI 2020-11-05 /pmc/articles/PMC7694531/ /pubmed/33167566 http://dx.doi.org/10.3390/v12111263 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sanchez Clemente, Nuria
Brickley, Elizabeth B.
Furquim de Almeida, Marcia
Witkin, Steven S.
Duarte Passos, Saulo
Can Zika Virus Infection in High Risk Pregnant Women Be Differentiated on the Basis of Symptoms?
title Can Zika Virus Infection in High Risk Pregnant Women Be Differentiated on the Basis of Symptoms?
title_full Can Zika Virus Infection in High Risk Pregnant Women Be Differentiated on the Basis of Symptoms?
title_fullStr Can Zika Virus Infection in High Risk Pregnant Women Be Differentiated on the Basis of Symptoms?
title_full_unstemmed Can Zika Virus Infection in High Risk Pregnant Women Be Differentiated on the Basis of Symptoms?
title_short Can Zika Virus Infection in High Risk Pregnant Women Be Differentiated on the Basis of Symptoms?
title_sort can zika virus infection in high risk pregnant women be differentiated on the basis of symptoms?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7694531/
https://www.ncbi.nlm.nih.gov/pubmed/33167566
http://dx.doi.org/10.3390/v12111263
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