The Trained Sniffer Dog Could Accurately Detect the Urine Samples from the Patients with Cervical Cancer, and Even Cervical Intraepithelial Neoplasia Grade 3: A Pilot Study

SIMPLE SUMMARY: Tumor detection by dog sniffing is a possible new method in cancer diagnosis. The aim of this study is to assess whether a trained dog can distinguish urine samples from cervical cancer patients. Urine samples were collected from 34 with cervical cancer, 49 patients with CIN3, 49 with benign uterine diseases, and 63 healthy volunteers. In all 83 test runs, one positive sample among five samples were presented to the dog. The trained dog accurately distinguished the urine sample of a cancer patient from those of the controls. This study showed that cancer detection by dog sniffing can be a non-invasive, cost-effective screening technique for cervical cancer. ABSTRACT: (1) Background: Previous reports have indicated that cancers of the stomach, lung, and pancreas can be detected by dog sniffing, but results have been varied. Here, a highly trained dog was used to determine whether urine from patients with cervical premalignant lesions and malignant tumors have a cancer-specific scent. (2) Methods: A total of 195 urine samples were collected from patients with cervical cancer, cervical intraepithelial neoplasia grade 3 (CIN3), benign uterine diseases, and healthy volunteers. Each test was performed using one urine sample from a cancer patient and four samples from different controls. Each of the five urine samples was placed in a separate box. When the cancer sniffing dog stopped and sat in front of the box with a sample from a cancer patient, the test was considered as positive. (3) Results: 83 patients with cervical cancer (34 cases of cervical cancer and 49 cases of cervical intraepithelial neoplasia grade 3), 49 patients with uterine benign diseases, and 63 healthy volunteers were enrolled, and their urine samples were collected. In 83 times out of 83 runs in a double-blind test, the trained dog could correctly identify urine samples of cervical cancer patients. (4) Conclusion: A trained dog could accurately distinguish the urine of all patients with cervical cancer or CIN3, regardless of the degree of cancer progression.