Cargando…
The Effects of Non-Nutritive Artificial Sweeteners, Aspartame and Sucralose, on the Gut Microbiome in Healthy Adults: Secondary Outcomes of a Randomized Double-Blinded Crossover Clinical Trial
Non-nutritive artificial sweeteners (NNSs) may have the ability to change the gut microbiota, which could potentially alter glucose metabolism. This study aimed to determine the effect of sucralose and aspartame consumption on gut microbiota composition using realistic doses of NNSs. Seventeen healt...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7694690/ https://www.ncbi.nlm.nih.gov/pubmed/33171964 http://dx.doi.org/10.3390/nu12113408 |
_version_ | 1783615033546113024 |
---|---|
author | Ahmad, Samar Y. Friel, James Mackay, Dylan |
author_facet | Ahmad, Samar Y. Friel, James Mackay, Dylan |
author_sort | Ahmad, Samar Y. |
collection | PubMed |
description | Non-nutritive artificial sweeteners (NNSs) may have the ability to change the gut microbiota, which could potentially alter glucose metabolism. This study aimed to determine the effect of sucralose and aspartame consumption on gut microbiota composition using realistic doses of NNSs. Seventeen healthy participants between the ages of 18 and 45 years who had a body mass index (BMI) of 20–25 were selected. They undertook two 14-day treatment periods separated by a four-week washout period. The sweeteners consumed by each participant consisted of a standardized dose of 14% (0.425 g) of the acceptable daily intake (ADI) for aspartame and 20% (0.136 g) of the ADI for sucralose. Faecal samples collected before and after treatments were analysed for microbiome and short-chain fatty acids (SCFAs). There were no differences in the median relative proportions of the most abundant bacterial taxa (family and genus) before and after treatments with both NNSs. The microbiota community structure also did not show any obvious differences. There were no differences in faecal SCFAs following the consumption of the NNSs. These findings suggest that daily repeated consumption of pure aspartame or sucralose in doses reflective of typical high consumption have minimal effect on gut microbiota composition or SCFA production. |
format | Online Article Text |
id | pubmed-7694690 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-76946902020-11-28 The Effects of Non-Nutritive Artificial Sweeteners, Aspartame and Sucralose, on the Gut Microbiome in Healthy Adults: Secondary Outcomes of a Randomized Double-Blinded Crossover Clinical Trial Ahmad, Samar Y. Friel, James Mackay, Dylan Nutrients Article Non-nutritive artificial sweeteners (NNSs) may have the ability to change the gut microbiota, which could potentially alter glucose metabolism. This study aimed to determine the effect of sucralose and aspartame consumption on gut microbiota composition using realistic doses of NNSs. Seventeen healthy participants between the ages of 18 and 45 years who had a body mass index (BMI) of 20–25 were selected. They undertook two 14-day treatment periods separated by a four-week washout period. The sweeteners consumed by each participant consisted of a standardized dose of 14% (0.425 g) of the acceptable daily intake (ADI) for aspartame and 20% (0.136 g) of the ADI for sucralose. Faecal samples collected before and after treatments were analysed for microbiome and short-chain fatty acids (SCFAs). There were no differences in the median relative proportions of the most abundant bacterial taxa (family and genus) before and after treatments with both NNSs. The microbiota community structure also did not show any obvious differences. There were no differences in faecal SCFAs following the consumption of the NNSs. These findings suggest that daily repeated consumption of pure aspartame or sucralose in doses reflective of typical high consumption have minimal effect on gut microbiota composition or SCFA production. MDPI 2020-11-06 /pmc/articles/PMC7694690/ /pubmed/33171964 http://dx.doi.org/10.3390/nu12113408 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Ahmad, Samar Y. Friel, James Mackay, Dylan The Effects of Non-Nutritive Artificial Sweeteners, Aspartame and Sucralose, on the Gut Microbiome in Healthy Adults: Secondary Outcomes of a Randomized Double-Blinded Crossover Clinical Trial |
title | The Effects of Non-Nutritive Artificial Sweeteners, Aspartame and Sucralose, on the Gut Microbiome in Healthy Adults: Secondary Outcomes of a Randomized Double-Blinded Crossover Clinical Trial |
title_full | The Effects of Non-Nutritive Artificial Sweeteners, Aspartame and Sucralose, on the Gut Microbiome in Healthy Adults: Secondary Outcomes of a Randomized Double-Blinded Crossover Clinical Trial |
title_fullStr | The Effects of Non-Nutritive Artificial Sweeteners, Aspartame and Sucralose, on the Gut Microbiome in Healthy Adults: Secondary Outcomes of a Randomized Double-Blinded Crossover Clinical Trial |
title_full_unstemmed | The Effects of Non-Nutritive Artificial Sweeteners, Aspartame and Sucralose, on the Gut Microbiome in Healthy Adults: Secondary Outcomes of a Randomized Double-Blinded Crossover Clinical Trial |
title_short | The Effects of Non-Nutritive Artificial Sweeteners, Aspartame and Sucralose, on the Gut Microbiome in Healthy Adults: Secondary Outcomes of a Randomized Double-Blinded Crossover Clinical Trial |
title_sort | effects of non-nutritive artificial sweeteners, aspartame and sucralose, on the gut microbiome in healthy adults: secondary outcomes of a randomized double-blinded crossover clinical trial |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7694690/ https://www.ncbi.nlm.nih.gov/pubmed/33171964 http://dx.doi.org/10.3390/nu12113408 |
work_keys_str_mv | AT ahmadsamary theeffectsofnonnutritiveartificialsweetenersaspartameandsucraloseonthegutmicrobiomeinhealthyadultssecondaryoutcomesofarandomizeddoubleblindedcrossoverclinicaltrial AT frieljames theeffectsofnonnutritiveartificialsweetenersaspartameandsucraloseonthegutmicrobiomeinhealthyadultssecondaryoutcomesofarandomizeddoubleblindedcrossoverclinicaltrial AT mackaydylan theeffectsofnonnutritiveartificialsweetenersaspartameandsucraloseonthegutmicrobiomeinhealthyadultssecondaryoutcomesofarandomizeddoubleblindedcrossoverclinicaltrial AT ahmadsamary effectsofnonnutritiveartificialsweetenersaspartameandsucraloseonthegutmicrobiomeinhealthyadultssecondaryoutcomesofarandomizeddoubleblindedcrossoverclinicaltrial AT frieljames effectsofnonnutritiveartificialsweetenersaspartameandsucraloseonthegutmicrobiomeinhealthyadultssecondaryoutcomesofarandomizeddoubleblindedcrossoverclinicaltrial AT mackaydylan effectsofnonnutritiveartificialsweetenersaspartameandsucraloseonthegutmicrobiomeinhealthyadultssecondaryoutcomesofarandomizeddoubleblindedcrossoverclinicaltrial |