Cargando…
Refractory Lupus Panniculitis Treated Successfully with Rituximab: Two Cases
Lupus panniculitis is usually difficult to treat, and the patient is often put on multiple immunosuppressives with variable clinical response and relapses, notwithstanding the long-term side effects. We describe two cases of refractory lupus panniculitis which have been treated successfully with rit...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7694699/ https://www.ncbi.nlm.nih.gov/pubmed/32820735 http://dx.doi.org/10.4103/aam.aam_42_19 |
_version_ | 1783615034717372416 |
---|---|
author | Gupta, Partisha Dhanawat, Aditya Mohanty, Ipsita Padhan, Prasanta |
author_facet | Gupta, Partisha Dhanawat, Aditya Mohanty, Ipsita Padhan, Prasanta |
author_sort | Gupta, Partisha |
collection | PubMed |
description | Lupus panniculitis is usually difficult to treat, and the patient is often put on multiple immunosuppressives with variable clinical response and relapses, notwithstanding the long-term side effects. We describe two cases of refractory lupus panniculitis which have been treated successfully with rituximab which is a chimeric anti-CD20 antibody. It reduces the number of circulating mature B-cells, thereby reducing the autoantibodies and the mediators of inflammation. Rituximab is a good alternative to patients who are not responsive to conventional treatment options for lupus panniculitis. There have been few side effects reported by the patients, but the clinical response and psychological well-being clearly outweigh them. |
format | Online Article Text |
id | pubmed-7694699 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-76946992020-12-02 Refractory Lupus Panniculitis Treated Successfully with Rituximab: Two Cases Gupta, Partisha Dhanawat, Aditya Mohanty, Ipsita Padhan, Prasanta Ann Afr Med Case Report Lupus panniculitis is usually difficult to treat, and the patient is often put on multiple immunosuppressives with variable clinical response and relapses, notwithstanding the long-term side effects. We describe two cases of refractory lupus panniculitis which have been treated successfully with rituximab which is a chimeric anti-CD20 antibody. It reduces the number of circulating mature B-cells, thereby reducing the autoantibodies and the mediators of inflammation. Rituximab is a good alternative to patients who are not responsive to conventional treatment options for lupus panniculitis. There have been few side effects reported by the patients, but the clinical response and psychological well-being clearly outweigh them. Wolters Kluwer - Medknow 2020 2020-08-19 /pmc/articles/PMC7694699/ /pubmed/32820735 http://dx.doi.org/10.4103/aam.aam_42_19 Text en Copyright: © 2020 Annals of African Medicine http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Case Report Gupta, Partisha Dhanawat, Aditya Mohanty, Ipsita Padhan, Prasanta Refractory Lupus Panniculitis Treated Successfully with Rituximab: Two Cases |
title | Refractory Lupus Panniculitis Treated Successfully with Rituximab: Two Cases |
title_full | Refractory Lupus Panniculitis Treated Successfully with Rituximab: Two Cases |
title_fullStr | Refractory Lupus Panniculitis Treated Successfully with Rituximab: Two Cases |
title_full_unstemmed | Refractory Lupus Panniculitis Treated Successfully with Rituximab: Two Cases |
title_short | Refractory Lupus Panniculitis Treated Successfully with Rituximab: Two Cases |
title_sort | refractory lupus panniculitis treated successfully with rituximab: two cases |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7694699/ https://www.ncbi.nlm.nih.gov/pubmed/32820735 http://dx.doi.org/10.4103/aam.aam_42_19 |
work_keys_str_mv | AT guptapartisha refractorylupuspanniculitistreatedsuccessfullywithrituximabtwocases AT dhanawataditya refractorylupuspanniculitistreatedsuccessfullywithrituximabtwocases AT mohantyipsita refractorylupuspanniculitistreatedsuccessfullywithrituximabtwocases AT padhanprasanta refractorylupuspanniculitistreatedsuccessfullywithrituximabtwocases |