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Hemorrhage and complications associated with percutaneous ultrasound guided liver biopsy in dogs

BACKGROUND: Liver biopsy is often necessary to obtain a diagnosis in dogs with hepatobiliary disease. Hemorrhage after biopsy is a concern. OBJECTIVE: To describe the extent of hemorrhage and incidence of complications after percutaneous ultrasound guided liver biopsy (PUGLB) in dogs and to examine...

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Autores principales: Reece, Jonjo, Pavlick, Michelle, Penninck, Dominique G., Webster, Cynthia R. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7694835/
https://www.ncbi.nlm.nih.gov/pubmed/33125175
http://dx.doi.org/10.1111/jvim.15942
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author Reece, Jonjo
Pavlick, Michelle
Penninck, Dominique G.
Webster, Cynthia R. L.
author_facet Reece, Jonjo
Pavlick, Michelle
Penninck, Dominique G.
Webster, Cynthia R. L.
author_sort Reece, Jonjo
collection PubMed
description BACKGROUND: Liver biopsy is often necessary to obtain a diagnosis in dogs with hepatobiliary disease. Hemorrhage after biopsy is a concern. OBJECTIVE: To describe the extent of hemorrhage and incidence of complications after percutaneous ultrasound guided liver biopsy (PUGLB) in dogs and to examine risk factors for hemorrhage or complications. ANIMALS: One hundred two client owned dogs with suspected hepatobiliary disease that underwent PUGLB. METHODS: Medical records were retrospectively reviewed. Using human guidelines, major hemorrhage was defined as an absolute decrease in the PCV (ΔPCV) ≥ 6%. Complications were defined separately as clinically relevant physiologic compromise that necessitated intervention or death. The relationship between ΔPCV and the occurrence of complications and the initial PCV, coagulation variables, serum activity of liver‐derived enzymes, serum bilirubin concentration, number of biopsies, biopsy needle gauge, radiologist experience, histological diagnosis, and ultrasound variables were compared. RESULTS: Before PUGLB, most aberrations in coagulation variables were mild. After biopsy a decrease in PCV occurred in 87/102 (85.3%) dogs. The mean ΔPCV was −7.2% ± 4.5%. Major hemorrhage occurred in 43/102 (42.2%) dogs and complications in 2/102 (1.9%). ΔPCV was significantly positively correlated with PCV before biopsy (r = .47, P = .004). There was no correlation between ΔPCV or complications with any of the variables examined. CONCLUSION AND CLINICAL IMPORTANCE: Percutaneous ultrasound guided liver biopsy in the population of dogs in the current study, with normal or mild abnormalities in coagulation, results in a high incidence of clinically silent, major hemorrhage (42.5%), but few complications (1.9%).
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spelling pubmed-76948352020-12-07 Hemorrhage and complications associated with percutaneous ultrasound guided liver biopsy in dogs Reece, Jonjo Pavlick, Michelle Penninck, Dominique G. Webster, Cynthia R. L. J Vet Intern Med SMALL ANIMAL BACKGROUND: Liver biopsy is often necessary to obtain a diagnosis in dogs with hepatobiliary disease. Hemorrhage after biopsy is a concern. OBJECTIVE: To describe the extent of hemorrhage and incidence of complications after percutaneous ultrasound guided liver biopsy (PUGLB) in dogs and to examine risk factors for hemorrhage or complications. ANIMALS: One hundred two client owned dogs with suspected hepatobiliary disease that underwent PUGLB. METHODS: Medical records were retrospectively reviewed. Using human guidelines, major hemorrhage was defined as an absolute decrease in the PCV (ΔPCV) ≥ 6%. Complications were defined separately as clinically relevant physiologic compromise that necessitated intervention or death. The relationship between ΔPCV and the occurrence of complications and the initial PCV, coagulation variables, serum activity of liver‐derived enzymes, serum bilirubin concentration, number of biopsies, biopsy needle gauge, radiologist experience, histological diagnosis, and ultrasound variables were compared. RESULTS: Before PUGLB, most aberrations in coagulation variables were mild. After biopsy a decrease in PCV occurred in 87/102 (85.3%) dogs. The mean ΔPCV was −7.2% ± 4.5%. Major hemorrhage occurred in 43/102 (42.2%) dogs and complications in 2/102 (1.9%). ΔPCV was significantly positively correlated with PCV before biopsy (r = .47, P = .004). There was no correlation between ΔPCV or complications with any of the variables examined. CONCLUSION AND CLINICAL IMPORTANCE: Percutaneous ultrasound guided liver biopsy in the population of dogs in the current study, with normal or mild abnormalities in coagulation, results in a high incidence of clinically silent, major hemorrhage (42.5%), but few complications (1.9%). John Wiley & Sons, Inc. 2020-10-30 2020 /pmc/articles/PMC7694835/ /pubmed/33125175 http://dx.doi.org/10.1111/jvim.15942 Text en © 2020 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC on behalf of American College of Veterinary Internal Medicine. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle SMALL ANIMAL
Reece, Jonjo
Pavlick, Michelle
Penninck, Dominique G.
Webster, Cynthia R. L.
Hemorrhage and complications associated with percutaneous ultrasound guided liver biopsy in dogs
title Hemorrhage and complications associated with percutaneous ultrasound guided liver biopsy in dogs
title_full Hemorrhage and complications associated with percutaneous ultrasound guided liver biopsy in dogs
title_fullStr Hemorrhage and complications associated with percutaneous ultrasound guided liver biopsy in dogs
title_full_unstemmed Hemorrhage and complications associated with percutaneous ultrasound guided liver biopsy in dogs
title_short Hemorrhage and complications associated with percutaneous ultrasound guided liver biopsy in dogs
title_sort hemorrhage and complications associated with percutaneous ultrasound guided liver biopsy in dogs
topic SMALL ANIMAL
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7694835/
https://www.ncbi.nlm.nih.gov/pubmed/33125175
http://dx.doi.org/10.1111/jvim.15942
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