The Denominator Matters! Lessons from Large Database Research in Neonatology

Observational studies from large datasets are becoming more common in neonatology. In this review, we highlight the importance of the denominator in study design and interpretation including examples of bias from source data, weight-based categories, age-related bias, and diagnosis-based denominator...

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Detalles Bibliográficos
Autores principales: Tolia, Veeral N., Clark, Reese H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7694961/
https://www.ncbi.nlm.nih.gov/pubmed/33171732
http://dx.doi.org/10.3390/children7110216
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author Tolia, Veeral N.
Clark, Reese H.
author_facet Tolia, Veeral N.
Clark, Reese H.
author_sort Tolia, Veeral N.
collection PubMed
description Observational studies from large datasets are becoming more common in neonatology. In this review, we highlight the importance of the denominator in study design and interpretation including examples of bias from source data, weight-based categories, age-related bias, and diagnosis-based denominators.
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spelling pubmed-76949612020-11-28 The Denominator Matters! Lessons from Large Database Research in Neonatology Tolia, Veeral N. Clark, Reese H. Children (Basel) Review Observational studies from large datasets are becoming more common in neonatology. In this review, we highlight the importance of the denominator in study design and interpretation including examples of bias from source data, weight-based categories, age-related bias, and diagnosis-based denominators. MDPI 2020-11-07 /pmc/articles/PMC7694961/ /pubmed/33171732 http://dx.doi.org/10.3390/children7110216 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tolia, Veeral N.
Clark, Reese H.
The Denominator Matters! Lessons from Large Database Research in Neonatology
title The Denominator Matters! Lessons from Large Database Research in Neonatology
title_full The Denominator Matters! Lessons from Large Database Research in Neonatology
title_fullStr The Denominator Matters! Lessons from Large Database Research in Neonatology
title_full_unstemmed The Denominator Matters! Lessons from Large Database Research in Neonatology
title_short The Denominator Matters! Lessons from Large Database Research in Neonatology
title_sort denominator matters! lessons from large database research in neonatology
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7694961/
https://www.ncbi.nlm.nih.gov/pubmed/33171732
http://dx.doi.org/10.3390/children7110216
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