Structure of the Diphtheria Toxin at Acidic pH: Implications for the Conformational Switching of the Translocation Domain

Diphtheria toxin, an exotoxin secreted by Corynebacterium that causes disease in humans by inhibiting protein synthesis, enters the cell via receptor-mediated endocytosis. The subsequent endosomal acidification triggers a series of conformational changes, resulting in the refolding and membrane inse...

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Detalles Bibliográficos
Autores principales: Rodnin, Mykola V., Kashipathy, Maithri M., Kyrychenko, Alexander, Battaile, Kevin P., Lovell, Scott, Ladokhin, Alexey S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695028/
https://www.ncbi.nlm.nih.gov/pubmed/33171806
http://dx.doi.org/10.3390/toxins12110704

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