Cargando…

Relationship between Dietary Fiber Intake and the Prognosis of Amytrophic Lateral Sclerosis in Korea

The gut microbiota has been suggested as an important factor in the pathogenic mechanisms of amyotrophic lateral sclerosis (ALS). This study aimed to investigate whether the intake of different kinds of dietary fiber was related to the disease progression rate (∆FS) and survival time. In total, 272...

Descripción completa

Detalles Bibliográficos
Autores principales: Yu, Haelim, Kim, Seung Hyun, Noh, Min-Young, Lee, Sanggon, Park, Yongsoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695159/
https://www.ncbi.nlm.nih.gov/pubmed/33171846
http://dx.doi.org/10.3390/nu12113420
_version_ 1783615126229745664
author Yu, Haelim
Kim, Seung Hyun
Noh, Min-Young
Lee, Sanggon
Park, Yongsoon
author_facet Yu, Haelim
Kim, Seung Hyun
Noh, Min-Young
Lee, Sanggon
Park, Yongsoon
author_sort Yu, Haelim
collection PubMed
description The gut microbiota has been suggested as an important factor in the pathogenic mechanisms of amyotrophic lateral sclerosis (ALS). This study aimed to investigate whether the intake of different kinds of dietary fiber was related to the disease progression rate (∆FS) and survival time. In total, 272 Korean sporadic ALS patients diagnosed according to the revised EI Escorial criteria were recruited starting in March 2011 and were followed until the occurrence of events or the end of September 2020. The events included percutaneous endoscopic gastrostomy, tracheostomy, and death. Dietary fiber intake was calculated based on a 24-h dietary recall and classified according to five major fiber-rich foods: vegetables, fruits, grains, legumes, and nuts/seeds. Among the total participants, the group with ∆FS values lower than the mean ∆FS (0.75) was noted in the highest tertiles of total and vegetable fiber intake. Participants in the highest tertile for vegetable fiber intake showed longer survival in the Kaplan–Meier analysis (p = 0.033). Notably, vegetable fiber intake was negatively correlated with pro-inflammatory cytokine (interleukin (IL)-1β, IL-6, and monocyte chemoattractant protein-1) levels in the cerebrospinal fluid. This study showed that vegetable fiber intake could influence the disease progression rate and survival time. Further clinical trials are needed to confirm whether dietary fiber supplementation improves the prognosis of ALS.
format Online
Article
Text
id pubmed-7695159
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-76951592020-11-28 Relationship between Dietary Fiber Intake and the Prognosis of Amytrophic Lateral Sclerosis in Korea Yu, Haelim Kim, Seung Hyun Noh, Min-Young Lee, Sanggon Park, Yongsoon Nutrients Article The gut microbiota has been suggested as an important factor in the pathogenic mechanisms of amyotrophic lateral sclerosis (ALS). This study aimed to investigate whether the intake of different kinds of dietary fiber was related to the disease progression rate (∆FS) and survival time. In total, 272 Korean sporadic ALS patients diagnosed according to the revised EI Escorial criteria were recruited starting in March 2011 and were followed until the occurrence of events or the end of September 2020. The events included percutaneous endoscopic gastrostomy, tracheostomy, and death. Dietary fiber intake was calculated based on a 24-h dietary recall and classified according to five major fiber-rich foods: vegetables, fruits, grains, legumes, and nuts/seeds. Among the total participants, the group with ∆FS values lower than the mean ∆FS (0.75) was noted in the highest tertiles of total and vegetable fiber intake. Participants in the highest tertile for vegetable fiber intake showed longer survival in the Kaplan–Meier analysis (p = 0.033). Notably, vegetable fiber intake was negatively correlated with pro-inflammatory cytokine (interleukin (IL)-1β, IL-6, and monocyte chemoattractant protein-1) levels in the cerebrospinal fluid. This study showed that vegetable fiber intake could influence the disease progression rate and survival time. Further clinical trials are needed to confirm whether dietary fiber supplementation improves the prognosis of ALS. MDPI 2020-11-07 /pmc/articles/PMC7695159/ /pubmed/33171846 http://dx.doi.org/10.3390/nu12113420 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yu, Haelim
Kim, Seung Hyun
Noh, Min-Young
Lee, Sanggon
Park, Yongsoon
Relationship between Dietary Fiber Intake and the Prognosis of Amytrophic Lateral Sclerosis in Korea
title Relationship between Dietary Fiber Intake and the Prognosis of Amytrophic Lateral Sclerosis in Korea
title_full Relationship between Dietary Fiber Intake and the Prognosis of Amytrophic Lateral Sclerosis in Korea
title_fullStr Relationship between Dietary Fiber Intake and the Prognosis of Amytrophic Lateral Sclerosis in Korea
title_full_unstemmed Relationship between Dietary Fiber Intake and the Prognosis of Amytrophic Lateral Sclerosis in Korea
title_short Relationship between Dietary Fiber Intake and the Prognosis of Amytrophic Lateral Sclerosis in Korea
title_sort relationship between dietary fiber intake and the prognosis of amytrophic lateral sclerosis in korea
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695159/
https://www.ncbi.nlm.nih.gov/pubmed/33171846
http://dx.doi.org/10.3390/nu12113420
work_keys_str_mv AT yuhaelim relationshipbetweendietaryfiberintakeandtheprognosisofamytrophiclateralsclerosisinkorea
AT kimseunghyun relationshipbetweendietaryfiberintakeandtheprognosisofamytrophiclateralsclerosisinkorea
AT nohminyoung relationshipbetweendietaryfiberintakeandtheprognosisofamytrophiclateralsclerosisinkorea
AT leesanggon relationshipbetweendietaryfiberintakeandtheprognosisofamytrophiclateralsclerosisinkorea
AT parkyongsoon relationshipbetweendietaryfiberintakeandtheprognosisofamytrophiclateralsclerosisinkorea