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Pain Characteristics and Associations with Quality of Life in Patients with Multiple Sclerosis in Lithuania

Background and objectives: Even though pain in multiple sclerosis (MS) patients is common and possibly associated with reduced quality of life, its exact prevalence and characteristics remain vaguely understood. We aimed to estimate the true extent of pain and its associations with quality of life i...

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Autores principales: Veličkaitė, Greta, Jucevičiūtė, Neringa, Balnytė, Renata, Laucius, Ovidijus, Vaitkus, Antanas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695204/
https://www.ncbi.nlm.nih.gov/pubmed/33171619
http://dx.doi.org/10.3390/medicina56110596
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author Veličkaitė, Greta
Jucevičiūtė, Neringa
Balnytė, Renata
Laucius, Ovidijus
Vaitkus, Antanas
author_facet Veličkaitė, Greta
Jucevičiūtė, Neringa
Balnytė, Renata
Laucius, Ovidijus
Vaitkus, Antanas
author_sort Veličkaitė, Greta
collection PubMed
description Background and objectives: Even though pain in multiple sclerosis (MS) patients is common and possibly associated with reduced quality of life, its exact prevalence and characteristics remain vaguely understood. We aimed to estimate the true extent of pain and its associations with quality of life in Lithuanian MS patients and to compare this data with that of a control group. Materials and Methods: Data were collected prospectively at the Department of Neurology, Lithuanian University of Health Sciences Kaunas Clinics. A face-to-face structured interview and a questionnaire were used to collect demographic and clinical data of the MS (n = 120) and control (n = 120) groups. The Expanded Disability Status Scale (EDSS) was used to quantify disability in the MS group. Scores ≥4/10 in the Douleur Neuropathique 4 questionnaire were classified as neuropathic pain. Patients were evaluated using the anxiety and depression subsets of the Hospital Anxiety and Depression Scale (HADS-A and HADS-D), the physical and mental component subsets of the Short Form-12 questionnaire (PSC-12 and MSC-12). Results: The MS and control groups did not differ in pain prevalence (76.7% vs. 65.9%, p = 0.064) or intensity. Lhermitte sign, lower limb, and face pain were more common in the MS group, whereas subjects in the control group were more often affected by lower back, neck, and joint pain. Neuropathic pain and pain lasting longer than 2 years were more common among pain-affected MS patients than among controls. MS patients with pain had higher EDSS, HADS-D, and HADS-A and lower PSC-12 scores than those without pain; however, no difference was found regarding the duration of MS or age. Males with MS and pain had higher MSC-12 and HADS-D scores in comparison to the same subset of females. Conclusions: Pain affects approximately three out of four patients with MS in Lithuania and is negatively associated with the mental and physical aspects of quality of life.
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spelling pubmed-76952042020-11-28 Pain Characteristics and Associations with Quality of Life in Patients with Multiple Sclerosis in Lithuania Veličkaitė, Greta Jucevičiūtė, Neringa Balnytė, Renata Laucius, Ovidijus Vaitkus, Antanas Medicina (Kaunas) Article Background and objectives: Even though pain in multiple sclerosis (MS) patients is common and possibly associated with reduced quality of life, its exact prevalence and characteristics remain vaguely understood. We aimed to estimate the true extent of pain and its associations with quality of life in Lithuanian MS patients and to compare this data with that of a control group. Materials and Methods: Data were collected prospectively at the Department of Neurology, Lithuanian University of Health Sciences Kaunas Clinics. A face-to-face structured interview and a questionnaire were used to collect demographic and clinical data of the MS (n = 120) and control (n = 120) groups. The Expanded Disability Status Scale (EDSS) was used to quantify disability in the MS group. Scores ≥4/10 in the Douleur Neuropathique 4 questionnaire were classified as neuropathic pain. Patients were evaluated using the anxiety and depression subsets of the Hospital Anxiety and Depression Scale (HADS-A and HADS-D), the physical and mental component subsets of the Short Form-12 questionnaire (PSC-12 and MSC-12). Results: The MS and control groups did not differ in pain prevalence (76.7% vs. 65.9%, p = 0.064) or intensity. Lhermitte sign, lower limb, and face pain were more common in the MS group, whereas subjects in the control group were more often affected by lower back, neck, and joint pain. Neuropathic pain and pain lasting longer than 2 years were more common among pain-affected MS patients than among controls. MS patients with pain had higher EDSS, HADS-D, and HADS-A and lower PSC-12 scores than those without pain; however, no difference was found regarding the duration of MS or age. Males with MS and pain had higher MSC-12 and HADS-D scores in comparison to the same subset of females. Conclusions: Pain affects approximately three out of four patients with MS in Lithuania and is negatively associated with the mental and physical aspects of quality of life. MDPI 2020-11-08 /pmc/articles/PMC7695204/ /pubmed/33171619 http://dx.doi.org/10.3390/medicina56110596 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Veličkaitė, Greta
Jucevičiūtė, Neringa
Balnytė, Renata
Laucius, Ovidijus
Vaitkus, Antanas
Pain Characteristics and Associations with Quality of Life in Patients with Multiple Sclerosis in Lithuania
title Pain Characteristics and Associations with Quality of Life in Patients with Multiple Sclerosis in Lithuania
title_full Pain Characteristics and Associations with Quality of Life in Patients with Multiple Sclerosis in Lithuania
title_fullStr Pain Characteristics and Associations with Quality of Life in Patients with Multiple Sclerosis in Lithuania
title_full_unstemmed Pain Characteristics and Associations with Quality of Life in Patients with Multiple Sclerosis in Lithuania
title_short Pain Characteristics and Associations with Quality of Life in Patients with Multiple Sclerosis in Lithuania
title_sort pain characteristics and associations with quality of life in patients with multiple sclerosis in lithuania
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695204/
https://www.ncbi.nlm.nih.gov/pubmed/33171619
http://dx.doi.org/10.3390/medicina56110596
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