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Synthesis and Stabilization of Gold Nanoparticles Using Water-Soluble Synthetic and Natural Polymers

Gold nanoparticles (AuNPs) were synthesized and stabilized using the one-pot method and growth seeding, through utilization of synthetic polymers, including poly(N-vinylpyrrolidone) (PVP), poly(ethylene glycol) (PEG), and poly(vinylcaprolactame) (PVCL), as well as natural polysaccharides, including...

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Autores principales: Nurakhmetova, Zhanara A., Azhkeyeva, Aiganym N., Klassen, Ivan A., Tatykhanova, Gulnur S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695247/
https://www.ncbi.nlm.nih.gov/pubmed/33171660
http://dx.doi.org/10.3390/polym12112625
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author Nurakhmetova, Zhanara A.
Azhkeyeva, Aiganym N.
Klassen, Ivan A.
Tatykhanova, Gulnur S.
author_facet Nurakhmetova, Zhanara A.
Azhkeyeva, Aiganym N.
Klassen, Ivan A.
Tatykhanova, Gulnur S.
author_sort Nurakhmetova, Zhanara A.
collection PubMed
description Gold nanoparticles (AuNPs) were synthesized and stabilized using the one-pot method and growth seeding, through utilization of synthetic polymers, including poly(N-vinylpyrrolidone) (PVP), poly(ethylene glycol) (PEG), and poly(vinylcaprolactame) (PVCL), as well as natural polysaccharides, including gellan, welan, pectin, and κ-carrageenan. The absorption spectra, average hydrodynamic size, ζ-potential, and morphology of the gold nanoparticles were evaluated based on various factors, such as polymer concentration, molecular mass of polymers, temperature, and storage time. The optimal polymer concentration for stabilization of AuNPs was found to be 4.0 wt % for PVP, 0.5 wt % for gellan, and 0.2 wt % for pectin, welan, and κ-carrageenan. The values of the ζ-potential of polymer-stabilized AuNPs show that their surfaces are negatively charged. Most of the AuNPs are polydisperse particles, though very monodisperse AuNPs were detected in the presence of a 0.5 wt % gellan solution. At a constant polymer concentration of PVP (4 wt %), the average size of the PVP–AuNPs decreased with the decrease of molecular weight, and in the following order: PVP 350 kDa (~25 nm) > PVP 40 kDa (~8 nm) > PVP 10 kDa (~4 nm). The combination of Fourier-transform infrared spectroscopy (FTIR) and Raman spectroscopy revealed that the functional groups of polymers that are responsible for stabilization of AuNPs are lactam ring in PVP, carboxylic groups in gellan and welan, esterified carboxylic groups in pectin, and SO(2) groups in κ-carrageenan. Viscometric and proton nuclear magnetic resonance ((1)H NMR) spectroscopic measurements showed that the temperature-dependent change in the size of AuNPs, and the gradual increase of the intensity of AuNPs at 550 nm in the presence of gellan, is due to the rigid and disordered conformation of gellan that affects the stabilization of AuNPs. The AuNPs synthesized in the presence of water-soluble polymers were stable over a period of 36 days. Preliminary results on the synthesis and characterization of gold nanorods stabilized by polymers are also presented.
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spelling pubmed-76952472020-11-28 Synthesis and Stabilization of Gold Nanoparticles Using Water-Soluble Synthetic and Natural Polymers Nurakhmetova, Zhanara A. Azhkeyeva, Aiganym N. Klassen, Ivan A. Tatykhanova, Gulnur S. Polymers (Basel) Article Gold nanoparticles (AuNPs) were synthesized and stabilized using the one-pot method and growth seeding, through utilization of synthetic polymers, including poly(N-vinylpyrrolidone) (PVP), poly(ethylene glycol) (PEG), and poly(vinylcaprolactame) (PVCL), as well as natural polysaccharides, including gellan, welan, pectin, and κ-carrageenan. The absorption spectra, average hydrodynamic size, ζ-potential, and morphology of the gold nanoparticles were evaluated based on various factors, such as polymer concentration, molecular mass of polymers, temperature, and storage time. The optimal polymer concentration for stabilization of AuNPs was found to be 4.0 wt % for PVP, 0.5 wt % for gellan, and 0.2 wt % for pectin, welan, and κ-carrageenan. The values of the ζ-potential of polymer-stabilized AuNPs show that their surfaces are negatively charged. Most of the AuNPs are polydisperse particles, though very monodisperse AuNPs were detected in the presence of a 0.5 wt % gellan solution. At a constant polymer concentration of PVP (4 wt %), the average size of the PVP–AuNPs decreased with the decrease of molecular weight, and in the following order: PVP 350 kDa (~25 nm) > PVP 40 kDa (~8 nm) > PVP 10 kDa (~4 nm). The combination of Fourier-transform infrared spectroscopy (FTIR) and Raman spectroscopy revealed that the functional groups of polymers that are responsible for stabilization of AuNPs are lactam ring in PVP, carboxylic groups in gellan and welan, esterified carboxylic groups in pectin, and SO(2) groups in κ-carrageenan. Viscometric and proton nuclear magnetic resonance ((1)H NMR) spectroscopic measurements showed that the temperature-dependent change in the size of AuNPs, and the gradual increase of the intensity of AuNPs at 550 nm in the presence of gellan, is due to the rigid and disordered conformation of gellan that affects the stabilization of AuNPs. The AuNPs synthesized in the presence of water-soluble polymers were stable over a period of 36 days. Preliminary results on the synthesis and characterization of gold nanorods stabilized by polymers are also presented. MDPI 2020-11-08 /pmc/articles/PMC7695247/ /pubmed/33171660 http://dx.doi.org/10.3390/polym12112625 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Nurakhmetova, Zhanara A.
Azhkeyeva, Aiganym N.
Klassen, Ivan A.
Tatykhanova, Gulnur S.
Synthesis and Stabilization of Gold Nanoparticles Using Water-Soluble Synthetic and Natural Polymers
title Synthesis and Stabilization of Gold Nanoparticles Using Water-Soluble Synthetic and Natural Polymers
title_full Synthesis and Stabilization of Gold Nanoparticles Using Water-Soluble Synthetic and Natural Polymers
title_fullStr Synthesis and Stabilization of Gold Nanoparticles Using Water-Soluble Synthetic and Natural Polymers
title_full_unstemmed Synthesis and Stabilization of Gold Nanoparticles Using Water-Soluble Synthetic and Natural Polymers
title_short Synthesis and Stabilization of Gold Nanoparticles Using Water-Soluble Synthetic and Natural Polymers
title_sort synthesis and stabilization of gold nanoparticles using water-soluble synthetic and natural polymers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695247/
https://www.ncbi.nlm.nih.gov/pubmed/33171660
http://dx.doi.org/10.3390/polym12112625
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