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Higher Disease and Pain Severity and Fatigue and Lower Balance Skills Are Associated with Higher Prevalence of Falling among Individuals with the Inflammatory Disease of Neuromyelitis Optica Spectrum Disorder (NMOSD)

Background: Neuromyelitis optica spectrum disorder (NMOSD) is a chronic inflammatory and autoimmune disorder that is associated with impaired vision, sensory loss, pain, fatigue, and spasms in the upper and lower limbs. Typically, persons with this disorder are also at higher risks of falls. Given t...

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Autores principales: Barzegar, Mahdi, Sadeghi Bahmani, Dena, Mirmosayyeb, Omid, Azarbayejani, Reyhaneh, Afshari-Safavi, Alireza, Vaheb, Saeed, Nehzat, Nasim, Dana, Afshin, Shaygannejad, Vahid, Motl, Robert W., Brand, Serge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695277/
https://www.ncbi.nlm.nih.gov/pubmed/33182291
http://dx.doi.org/10.3390/jcm9113604
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author Barzegar, Mahdi
Sadeghi Bahmani, Dena
Mirmosayyeb, Omid
Azarbayejani, Reyhaneh
Afshari-Safavi, Alireza
Vaheb, Saeed
Nehzat, Nasim
Dana, Afshin
Shaygannejad, Vahid
Motl, Robert W.
Brand, Serge
author_facet Barzegar, Mahdi
Sadeghi Bahmani, Dena
Mirmosayyeb, Omid
Azarbayejani, Reyhaneh
Afshari-Safavi, Alireza
Vaheb, Saeed
Nehzat, Nasim
Dana, Afshin
Shaygannejad, Vahid
Motl, Robert W.
Brand, Serge
author_sort Barzegar, Mahdi
collection PubMed
description Background: Neuromyelitis optica spectrum disorder (NMOSD) is a chronic inflammatory and autoimmune disorder that is associated with impaired vision, sensory loss, pain, fatigue, and spasms in the upper and lower limbs. Typically, persons with this disorder are also at higher risks of falls. Given this, the aims of the study were to compare the prevalence rates of falling for NMOSD cases and healthy controls (HCs), and to predict falling in the former group based on sociodemographic, psychological, and illness-related factors. Method: A total of 95 adults with NMOSD (Mean age = 34.89 years; 70.5% females) and 100 matched HCs took part in the study. All participants completed a series of questionnaires covering sociodemographic information and falling rates. The NMOSD individuals also reported on disease duration, pain, fatigue, and fear of falling, while their balance performance was objectively assessed. Results: Compared to healthy controls, the NMOSD cases had a 2.5-fold higher risk of falling. In this latter group, higher scores for pain, fatigue, fear of falling, and higher EDSS scores were distinguished between fallers and non-fallers, and objective balance skills had no predictive value. Conclusions: Compared to healthy controls, NMOSD sufferers had a 2.5-fold higher risk of experiencing falls. In this group, disease impairments (EDSS, fatigue, pain) predicted falling. Specific interventions such as regular resistance training might reduce the risk of falling.
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spelling pubmed-76952772020-11-28 Higher Disease and Pain Severity and Fatigue and Lower Balance Skills Are Associated with Higher Prevalence of Falling among Individuals with the Inflammatory Disease of Neuromyelitis Optica Spectrum Disorder (NMOSD) Barzegar, Mahdi Sadeghi Bahmani, Dena Mirmosayyeb, Omid Azarbayejani, Reyhaneh Afshari-Safavi, Alireza Vaheb, Saeed Nehzat, Nasim Dana, Afshin Shaygannejad, Vahid Motl, Robert W. Brand, Serge J Clin Med Article Background: Neuromyelitis optica spectrum disorder (NMOSD) is a chronic inflammatory and autoimmune disorder that is associated with impaired vision, sensory loss, pain, fatigue, and spasms in the upper and lower limbs. Typically, persons with this disorder are also at higher risks of falls. Given this, the aims of the study were to compare the prevalence rates of falling for NMOSD cases and healthy controls (HCs), and to predict falling in the former group based on sociodemographic, psychological, and illness-related factors. Method: A total of 95 adults with NMOSD (Mean age = 34.89 years; 70.5% females) and 100 matched HCs took part in the study. All participants completed a series of questionnaires covering sociodemographic information and falling rates. The NMOSD individuals also reported on disease duration, pain, fatigue, and fear of falling, while their balance performance was objectively assessed. Results: Compared to healthy controls, the NMOSD cases had a 2.5-fold higher risk of falling. In this latter group, higher scores for pain, fatigue, fear of falling, and higher EDSS scores were distinguished between fallers and non-fallers, and objective balance skills had no predictive value. Conclusions: Compared to healthy controls, NMOSD sufferers had a 2.5-fold higher risk of experiencing falls. In this group, disease impairments (EDSS, fatigue, pain) predicted falling. Specific interventions such as regular resistance training might reduce the risk of falling. MDPI 2020-11-09 /pmc/articles/PMC7695277/ /pubmed/33182291 http://dx.doi.org/10.3390/jcm9113604 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Barzegar, Mahdi
Sadeghi Bahmani, Dena
Mirmosayyeb, Omid
Azarbayejani, Reyhaneh
Afshari-Safavi, Alireza
Vaheb, Saeed
Nehzat, Nasim
Dana, Afshin
Shaygannejad, Vahid
Motl, Robert W.
Brand, Serge
Higher Disease and Pain Severity and Fatigue and Lower Balance Skills Are Associated with Higher Prevalence of Falling among Individuals with the Inflammatory Disease of Neuromyelitis Optica Spectrum Disorder (NMOSD)
title Higher Disease and Pain Severity and Fatigue and Lower Balance Skills Are Associated with Higher Prevalence of Falling among Individuals with the Inflammatory Disease of Neuromyelitis Optica Spectrum Disorder (NMOSD)
title_full Higher Disease and Pain Severity and Fatigue and Lower Balance Skills Are Associated with Higher Prevalence of Falling among Individuals with the Inflammatory Disease of Neuromyelitis Optica Spectrum Disorder (NMOSD)
title_fullStr Higher Disease and Pain Severity and Fatigue and Lower Balance Skills Are Associated with Higher Prevalence of Falling among Individuals with the Inflammatory Disease of Neuromyelitis Optica Spectrum Disorder (NMOSD)
title_full_unstemmed Higher Disease and Pain Severity and Fatigue and Lower Balance Skills Are Associated with Higher Prevalence of Falling among Individuals with the Inflammatory Disease of Neuromyelitis Optica Spectrum Disorder (NMOSD)
title_short Higher Disease and Pain Severity and Fatigue and Lower Balance Skills Are Associated with Higher Prevalence of Falling among Individuals with the Inflammatory Disease of Neuromyelitis Optica Spectrum Disorder (NMOSD)
title_sort higher disease and pain severity and fatigue and lower balance skills are associated with higher prevalence of falling among individuals with the inflammatory disease of neuromyelitis optica spectrum disorder (nmosd)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695277/
https://www.ncbi.nlm.nih.gov/pubmed/33182291
http://dx.doi.org/10.3390/jcm9113604
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