Calcitriol Suppresses HIF-1 and HIF-2 Transcriptional Activity by Reducing HIF-1/2α Protein Levels via a VDR-Independent Mechanism

Hypoxia-inducible transcription factors 1 and 2 (HIFs) are major mediators of cancer development and progression and validated targets for cancer therapy. Although calcitriol, the biologically active metabolite of vitamin D, was attributed with anticancer properties, there is little information on t...

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Detalles Bibliográficos
Autores principales: Gkotinakou, Ioanna-Maria, Kechagia, Eleni, Pazaitou-Panayiotou, Kalliopi, Mylonis, Ilias, Liakos, Panagiotis, Tsakalof, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695316/
https://www.ncbi.nlm.nih.gov/pubmed/33182300
http://dx.doi.org/10.3390/cells9112440

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695316/
https://www.ncbi.nlm.nih.gov/pubmed/33182300
http://dx.doi.org/10.3390/cells9112440

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