Niacin protects against abdominal aortic aneurysm formation via GPR109A independent mechanisms: role of NAD(+)/nicotinamide

AIMS: Chronic adventitial and medial infiltration of immune cells play an important role in the pathogenesis of abdominal aortic aneurysms (AAAs). Nicotinic acid (niacin) was shown to inhibit atherosclerosis by activating the anti-inflammatory G protein-coupled receptor GPR109A [also known as hydrox...

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Detalles Bibliográficos
Autores principales: Horimatsu, Tetsuo, Blomkalns, Andra L, Ogbi, Mourad, Moses, Mary, Kim, David, Patel, Sagar, Gilreath, Nicole, Reid, Lauren, Benson, Tyler W, Pye, Jonathan, Ahmadieh, Samah, Thompson, Allie, Robbins, Nathan, Mann, Adrien, Edgell, Ashlee, Benjamin, Stephanie, Stansfield, Brian K, Huo, Yuqing, Fulton, David J, Agarwal, Gautam, Singh, Nagendra, Offermanns, Stefan, Weintraub, Neal L, Kim, Ha Won
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695356/
https://www.ncbi.nlm.nih.gov/pubmed/31710686
http://dx.doi.org/10.1093/cvr/cvz303

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