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Pathogenic load and frailty in older adults: Singapore longitudinal ageing study

Human evidence for the role of continuous antigenic stimulation from persistent latent infections in frailty is limited. We conducted a nested case-control study (99 deceased and 43 survivors) of participants aged 55 and above in a longitudinal ageing cohort followed up from 2003 to 2017. Using bloo...

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Autores principales: Ng, Tze Pin, Lu, Yanxia, Tan, Crystal Tze Ying, Gao, Qi, Gwee, Xinyi, Fulop, Tamas, Larbi, Anis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695406/
https://www.ncbi.nlm.nih.gov/pubmed/33159019
http://dx.doi.org/10.18632/aging.104076
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author Ng, Tze Pin
Lu, Yanxia
Tan, Crystal Tze Ying
Gao, Qi
Gwee, Xinyi
Fulop, Tamas
Larbi, Anis
author_facet Ng, Tze Pin
Lu, Yanxia
Tan, Crystal Tze Ying
Gao, Qi
Gwee, Xinyi
Fulop, Tamas
Larbi, Anis
author_sort Ng, Tze Pin
collection PubMed
description Human evidence for the role of continuous antigenic stimulation from persistent latent infections in frailty is limited. We conducted a nested case-control study (99 deceased and 43 survivors) of participants aged 55 and above in a longitudinal ageing cohort followed up from 2003 to 2017. Using blood samples and baseline data collected in 2003-2004, we examined the association of pathogenic load (PL) count of seropositivity to 10 microbes (viruses, bacteria and mycoplasma) with cumulated deficit-frailty index (CD-FI) and the physical frailty (PF) phenotype, and mortality. Controlling for age, sex, education, smoking and alcohol histories, high PL (7-9) versus low PL (3-6) was associated with an estimated increase of 0.035 points in the CD-FI (Cohen’s D=0.035 / 0.086, or 0.41). High PL was associated with 8.5 times odds of being physically frail (p=0.001), 2.8 times odds of being weak (p=0.010), 3.4 times odds of being slow (p=0.024), and mortality hazard ratio of 1.53 (p=0.046). There were no significant associations for specific pathogens, except marginal associations for Epstein-Barr virus and Chikungunya. Conclusion: A high pathogenic load of latent infections was associated with increased risks of frailty and mortality.
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spelling pubmed-76954062020-12-04 Pathogenic load and frailty in older adults: Singapore longitudinal ageing study Ng, Tze Pin Lu, Yanxia Tan, Crystal Tze Ying Gao, Qi Gwee, Xinyi Fulop, Tamas Larbi, Anis Aging (Albany NY) Research Paper Human evidence for the role of continuous antigenic stimulation from persistent latent infections in frailty is limited. We conducted a nested case-control study (99 deceased and 43 survivors) of participants aged 55 and above in a longitudinal ageing cohort followed up from 2003 to 2017. Using blood samples and baseline data collected in 2003-2004, we examined the association of pathogenic load (PL) count of seropositivity to 10 microbes (viruses, bacteria and mycoplasma) with cumulated deficit-frailty index (CD-FI) and the physical frailty (PF) phenotype, and mortality. Controlling for age, sex, education, smoking and alcohol histories, high PL (7-9) versus low PL (3-6) was associated with an estimated increase of 0.035 points in the CD-FI (Cohen’s D=0.035 / 0.086, or 0.41). High PL was associated with 8.5 times odds of being physically frail (p=0.001), 2.8 times odds of being weak (p=0.010), 3.4 times odds of being slow (p=0.024), and mortality hazard ratio of 1.53 (p=0.046). There were no significant associations for specific pathogens, except marginal associations for Epstein-Barr virus and Chikungunya. Conclusion: A high pathogenic load of latent infections was associated with increased risks of frailty and mortality. Impact Journals 2020-11-06 /pmc/articles/PMC7695406/ /pubmed/33159019 http://dx.doi.org/10.18632/aging.104076 Text en Copyright: © 2020 Ng et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Ng, Tze Pin
Lu, Yanxia
Tan, Crystal Tze Ying
Gao, Qi
Gwee, Xinyi
Fulop, Tamas
Larbi, Anis
Pathogenic load and frailty in older adults: Singapore longitudinal ageing study
title Pathogenic load and frailty in older adults: Singapore longitudinal ageing study
title_full Pathogenic load and frailty in older adults: Singapore longitudinal ageing study
title_fullStr Pathogenic load and frailty in older adults: Singapore longitudinal ageing study
title_full_unstemmed Pathogenic load and frailty in older adults: Singapore longitudinal ageing study
title_short Pathogenic load and frailty in older adults: Singapore longitudinal ageing study
title_sort pathogenic load and frailty in older adults: singapore longitudinal ageing study
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695406/
https://www.ncbi.nlm.nih.gov/pubmed/33159019
http://dx.doi.org/10.18632/aging.104076
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