Nucleolar stress induces a senescence-like phenotype in smooth muscle cells and promotes development of vascular degeneration

Senescence of smooth muscle cells (SMCs) has a crucial role in the pathogenesis of abdominal aortic aneurysm (AAA), a disease of vascular degeneration. Perturbation of cellular ribosomal DNA (rDNA) transcription triggers nucleolar stress response. Previously we demonstrated that induction of nucleol...

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Detalles Bibliográficos
Autores principales: Zhang, Wenjing, Cheng, Wen, Parlato, Rosanna, Guo, Xiaosun, Cui, Xiaopei, Dai, Chaochao, Xu, Lei, Zhu, Jiankang, Zhu, Min, Luo, Kun, Zhang, Wencheng, Dong, Bo, Wang, Jianli, Jiang, Fan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695416/
https://www.ncbi.nlm.nih.gov/pubmed/33146634
http://dx.doi.org/10.18632/aging.104094

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