Islet vascularization is regulated by primary endothelial cilia via VEGF-A-dependent signaling

Islet vascularization is essential for intact islet function and glucose homeostasis. We have previously shown that primary cilia directly regulate insulin secretion. However, it remains unclear whether they are also implicated in islet vascularization. At eight weeks, murine Bbs4(-/-)islets show si...

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Detalles Bibliográficos
Autores principales: Xiong, Yan, Scerbo, M Julia, Seelig, Anett, Volta, Francesco, O'Brien, Nils, Dicker, Andrea, Padula, Daniela, Lickert, Heiko, Gerdes, Jantje Mareike, Berggren, Per-Olof
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695455/
https://www.ncbi.nlm.nih.gov/pubmed/33200981
http://dx.doi.org/10.7554/eLife.56914

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