CRISPR-mediated BMP9 ablation promotes liver steatosis via the down-regulation of PPARα expression

Obesity drives the development of nonalcoholic fatty liver disease (NAFLD) characterized by hepatic steatosis. Several bone morphogenetic proteins (BMPs) except BMP9 were reported related to metabolic syndrome. This study demonstrates that liver cytokine BMP9 is decreased in the liver and serum of N...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Z., Li, P., Shang, Q., Wang, Y., He, J., Ge, S., Jia, R., Fan, X.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695473/
https://www.ncbi.nlm.nih.gov/pubmed/33246954
http://dx.doi.org/10.1126/sciadv.abc5022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695473/
https://www.ncbi.nlm.nih.gov/pubmed/33246954
http://dx.doi.org/10.1126/sciadv.abc5022

Ejemplares similares