Multiple Roles of 25-Hydroxycholesterol in Lipid Metabolism, Antivirus Process, Inflammatory Response, and Cell Survival

As an essential lipid, cholesterol is of great value in keeping cell homeostasis, being the precursor of bile acid and steroid hormones, and stabilizing membrane lipid rafts. As a kind of cholesterol metabolite produced by enzymatic or radical process, oxysterols have drawn much attention in the las...

Descripción completa

Detalles Bibliográficos
Autores principales: Cao, Qin, Liu, Zhongzhong, Xiong, Yan, Zhong, Zibiao, Ye, Qifa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695496/
https://www.ncbi.nlm.nih.gov/pubmed/33274010
http://dx.doi.org/10.1155/2020/8893305
_version_ 1783615201307787264
author Cao, Qin
Liu, Zhongzhong
Xiong, Yan
Zhong, Zibiao
Ye, Qifa
author_facet Cao, Qin
Liu, Zhongzhong
Xiong, Yan
Zhong, Zibiao
Ye, Qifa
author_sort Cao, Qin
collection PubMed
description As an essential lipid, cholesterol is of great value in keeping cell homeostasis, being the precursor of bile acid and steroid hormones, and stabilizing membrane lipid rafts. As a kind of cholesterol metabolite produced by enzymatic or radical process, oxysterols have drawn much attention in the last decades. Among which, the role of 25-hydroxycholesterol (25-HC) in cholesterol and bile acid metabolism, antivirus process, and inflammatory response has been largely disclosed. This review is aimed at revealing these functions and underlying mechanisms of 25-HC.
format Online
Article
Text
id pubmed-7695496
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-76954962020-12-02 Multiple Roles of 25-Hydroxycholesterol in Lipid Metabolism, Antivirus Process, Inflammatory Response, and Cell Survival Cao, Qin Liu, Zhongzhong Xiong, Yan Zhong, Zibiao Ye, Qifa Oxid Med Cell Longev Review Article As an essential lipid, cholesterol is of great value in keeping cell homeostasis, being the precursor of bile acid and steroid hormones, and stabilizing membrane lipid rafts. As a kind of cholesterol metabolite produced by enzymatic or radical process, oxysterols have drawn much attention in the last decades. Among which, the role of 25-hydroxycholesterol (25-HC) in cholesterol and bile acid metabolism, antivirus process, and inflammatory response has been largely disclosed. This review is aimed at revealing these functions and underlying mechanisms of 25-HC. Hindawi 2020-11-19 /pmc/articles/PMC7695496/ /pubmed/33274010 http://dx.doi.org/10.1155/2020/8893305 Text en Copyright © 2020 Qin Cao et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Cao, Qin
Liu, Zhongzhong
Xiong, Yan
Zhong, Zibiao
Ye, Qifa
Multiple Roles of 25-Hydroxycholesterol in Lipid Metabolism, Antivirus Process, Inflammatory Response, and Cell Survival
title Multiple Roles of 25-Hydroxycholesterol in Lipid Metabolism, Antivirus Process, Inflammatory Response, and Cell Survival
title_full Multiple Roles of 25-Hydroxycholesterol in Lipid Metabolism, Antivirus Process, Inflammatory Response, and Cell Survival
title_fullStr Multiple Roles of 25-Hydroxycholesterol in Lipid Metabolism, Antivirus Process, Inflammatory Response, and Cell Survival
title_full_unstemmed Multiple Roles of 25-Hydroxycholesterol in Lipid Metabolism, Antivirus Process, Inflammatory Response, and Cell Survival
title_short Multiple Roles of 25-Hydroxycholesterol in Lipid Metabolism, Antivirus Process, Inflammatory Response, and Cell Survival
title_sort multiple roles of 25-hydroxycholesterol in lipid metabolism, antivirus process, inflammatory response, and cell survival
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695496/
https://www.ncbi.nlm.nih.gov/pubmed/33274010
http://dx.doi.org/10.1155/2020/8893305
work_keys_str_mv AT caoqin multiplerolesof25hydroxycholesterolinlipidmetabolismantivirusprocessinflammatoryresponseandcellsurvival
AT liuzhongzhong multiplerolesof25hydroxycholesterolinlipidmetabolismantivirusprocessinflammatoryresponseandcellsurvival
AT xiongyan multiplerolesof25hydroxycholesterolinlipidmetabolismantivirusprocessinflammatoryresponseandcellsurvival
AT zhongzibiao multiplerolesof25hydroxycholesterolinlipidmetabolismantivirusprocessinflammatoryresponseandcellsurvival
AT yeqifa multiplerolesof25hydroxycholesterolinlipidmetabolismantivirusprocessinflammatoryresponseandcellsurvival

Ejemplares similares