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Peripheral immunological features of COVID-19 patients in Taizhou, China: A retrospective study

BACKGROUND: Abnormal peripheral immunological features are associated with the progression of coronavirus disease 2019 (COVID-19). METHODS: Clinical and laboratory data were retrieved in a cohort of 146 laboratory-confirmed COVID-19 patients. Potential risk factors for the development of severe COVI...

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Autores principales: Jin, Xiao-Hong, Zhou, Hui-Li, Chen, Ling-Ling, Wang, Guan-Fu, Han, Qiu-Yue, Zhang, Jian-Gang, Zhang, Xia, Chen, Qiong-Yuan, Ye, Yao-Han, Lin, Aifen, Yan, Wei-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695552/
https://www.ncbi.nlm.nih.gov/pubmed/33253854
http://dx.doi.org/10.1016/j.clim.2020.108642
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author Jin, Xiao-Hong
Zhou, Hui-Li
Chen, Ling-Ling
Wang, Guan-Fu
Han, Qiu-Yue
Zhang, Jian-Gang
Zhang, Xia
Chen, Qiong-Yuan
Ye, Yao-Han
Lin, Aifen
Yan, Wei-Hua
author_facet Jin, Xiao-Hong
Zhou, Hui-Li
Chen, Ling-Ling
Wang, Guan-Fu
Han, Qiu-Yue
Zhang, Jian-Gang
Zhang, Xia
Chen, Qiong-Yuan
Ye, Yao-Han
Lin, Aifen
Yan, Wei-Hua
author_sort Jin, Xiao-Hong
collection PubMed
description BACKGROUND: Abnormal peripheral immunological features are associated with the progression of coronavirus disease 2019 (COVID-19). METHODS: Clinical and laboratory data were retrieved in a cohort of 146 laboratory-confirmed COVID-19 patients. Potential risk factors for the development of severe COVID-19 were evaluated. RESULTS: On admission, lymphocytes, CD3+, CD4+ and CD8+ T cells, eosinophils, and albumin and pre-albumin were dramatically lower, whereas neutrophils, and interleukin (IL)-10, C-reactive protein (CRP), aspartate aminotransferase (AST) and gamma-glutamyltransferase (GGT) were significantly higher in severe cases. By the second week after discharge, all variables improved to normal levels. Covariate logistic regression results showed that the CD8+ cell count and CRP level were independent risk factors for severe COVID-19. CONCLUSION: Lower peripheral immune cell subsets in patients with severe disease recovered to normal levels as early as the second week after discharge. CD8+ T cell counts and CRP levels on admission are independent predictive factors for severe COVID-19.
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spelling pubmed-76955522020-12-01 Peripheral immunological features of COVID-19 patients in Taizhou, China: A retrospective study Jin, Xiao-Hong Zhou, Hui-Li Chen, Ling-Ling Wang, Guan-Fu Han, Qiu-Yue Zhang, Jian-Gang Zhang, Xia Chen, Qiong-Yuan Ye, Yao-Han Lin, Aifen Yan, Wei-Hua Clin Immunol Full Length Article BACKGROUND: Abnormal peripheral immunological features are associated with the progression of coronavirus disease 2019 (COVID-19). METHODS: Clinical and laboratory data were retrieved in a cohort of 146 laboratory-confirmed COVID-19 patients. Potential risk factors for the development of severe COVID-19 were evaluated. RESULTS: On admission, lymphocytes, CD3+, CD4+ and CD8+ T cells, eosinophils, and albumin and pre-albumin were dramatically lower, whereas neutrophils, and interleukin (IL)-10, C-reactive protein (CRP), aspartate aminotransferase (AST) and gamma-glutamyltransferase (GGT) were significantly higher in severe cases. By the second week after discharge, all variables improved to normal levels. Covariate logistic regression results showed that the CD8+ cell count and CRP level were independent risk factors for severe COVID-19. CONCLUSION: Lower peripheral immune cell subsets in patients with severe disease recovered to normal levels as early as the second week after discharge. CD8+ T cell counts and CRP levels on admission are independent predictive factors for severe COVID-19. Elsevier Inc. 2021-01 2020-11-28 /pmc/articles/PMC7695552/ /pubmed/33253854 http://dx.doi.org/10.1016/j.clim.2020.108642 Text en © 2020 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Full Length Article
Jin, Xiao-Hong
Zhou, Hui-Li
Chen, Ling-Ling
Wang, Guan-Fu
Han, Qiu-Yue
Zhang, Jian-Gang
Zhang, Xia
Chen, Qiong-Yuan
Ye, Yao-Han
Lin, Aifen
Yan, Wei-Hua
Peripheral immunological features of COVID-19 patients in Taizhou, China: A retrospective study
title Peripheral immunological features of COVID-19 patients in Taizhou, China: A retrospective study
title_full Peripheral immunological features of COVID-19 patients in Taizhou, China: A retrospective study
title_fullStr Peripheral immunological features of COVID-19 patients in Taizhou, China: A retrospective study
title_full_unstemmed Peripheral immunological features of COVID-19 patients in Taizhou, China: A retrospective study
title_short Peripheral immunological features of COVID-19 patients in Taizhou, China: A retrospective study
title_sort peripheral immunological features of covid-19 patients in taizhou, china: a retrospective study
topic Full Length Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695552/
https://www.ncbi.nlm.nih.gov/pubmed/33253854
http://dx.doi.org/10.1016/j.clim.2020.108642
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